Evaluation of ruxolitinib, a JAK inhibitor, in multiple myeloma

by Impact Journals LLCRuxolitinib exerts its anti-myeloma effects through several mechanisms. Credit:Oncotarget(2024). DOI: 10.18632/oncotarget.28547A new research perspective titled &quot

Updated on: May 07,2024

Evaluation of ruxolitinib, a JAK inhibitor, in multiple myeloma

by Impact Journals LLCRuxolitinib exerts its anti-myeloma effects through several mechanisms. Credit:Oncotarget(2024). DOI: 10.18632/oncotarget.28547A new research perspective titled &quot

Updated on:May 07,2024

Preventing 'identity theft' in prostate cancer cells re-sensitizes them to therapy

byUT Southwestern Medical CenterJAK–STAT signaling is required for Enz resistance in TP53/RB1-deficient mCRPC.a, Heat map representing the significantly changed signaling pathways in LNCaP

Updated on: December 22,2023

Preventing 'identity theft' in prostate cancer cells re-sensitizes them to therapy

byUT Southwestern Medical CenterJAK–STAT signaling is required for Enz resistance in TP53/RB1-deficient mCRPC.a, Heat map representing the significantly changed signaling pathways in LNCaP

Updated on:December 22,2023

Researchers identify protein with DYRK1A-inhibiting effect that may have implications for Down syndrome

by Kyoto UniversityDYRK1A bound to FAM53C in the cytoplasm is less active. DYRK1A not bound to FAM53C in the nucleus is highly active. Functional abnormalities cause various neuropsychiatric deve

Updated on: February 20,2024

Researchers identify protein with DYRK1A-inhibiting effect that may have implications for Down syndrome

by Kyoto UniversityDYRK1A bound to FAM53C in the cytoplasm is less active. DYRK1A not bound to FAM53C in the nucleus is highly active. Functional abnormalities cause various neuropsychiatric deve

Updated on:February 20,2024

Protein spheres protect the genome of cancer cells

byUniversity of WürzburgMYC proteins are colored green in this figure. In normally growing cells, they are homogeneously distributed in the cell nucleus (left). In diverse stress situations, as

Updated on: December 20,2023

Protein spheres protect the genome of cancer cells

byUniversity of WürzburgMYC proteins are colored green in this figure. In normally growing cells, they are homogeneously distributed in the cell nucleus (left). In diverse stress situations, as

Updated on:December 20,2023

Understanding breast cancer recurrence, metastatic spread

byUniversity of CincinnatiCredit: Unsplash/CC0 Public DomainDespite advancements in cancer detection and treatment, breast cancer that comes back or spreads still presents a challenge to researc

Updated on: December 28,2023

Understanding breast cancer recurrence, metastatic spread

byUniversity of CincinnatiCredit: Unsplash/CC0 Public DomainDespite advancements in cancer detection and treatment, breast cancer that comes back or spreads still presents a challenge to researc

Updated on:December 28,2023

Testosterone is an ally of macrophages in the battle against adrenal cancers

byCNRSMacrophages attacking adrenal tumor in male mouse. Credit: © Julie Olabe CNRS/GReDWhy are cancers of the adrenal glands more common among women? Why are prognoses worse for them? A team of

Updated on: December 22,2023

Testosterone is an ally of macrophages in the battle against adrenal cancers

byCNRSMacrophages attacking adrenal tumor in male mouse. Credit: © Julie Olabe CNRS/GReDWhy are cancers of the adrenal glands more common among women? Why are prognoses worse for them? A team of

Updated on:December 22,2023

New, revised topics released in ACR appropriateness criteria

(HealthDay)—The latest edition of the American College of Radiology (ACR) Appropriateness Criteria has been released and includes 188 diagnostic imaging and interventional radiology topics, with 908 c

Updated on: May 05,2024

New, revised topics released in ACR appropriateness criteria

(HealthDay)—The latest edition of the American College of Radiology (ACR) Appropriateness Criteria has been released and includes 188 diagnostic imaging and interventional radiology topics, with 908 c

Updated on:May 05,2024

Chemically 'poisoned' protein acts as a molecular switch to spur cancer formation

byThe Scripps Research InstituteResearchers discovered that when the protein DNMT3B becomes S-nitrosylated in the presence of nitric oxide (NO), cancer-related genes become activated, leading to

Updated on: December 25,2023

Chemically 'poisoned' protein acts as a molecular switch to spur cancer formation

byThe Scripps Research InstituteResearchers discovered that when the protein DNMT3B becomes S-nitrosylated in the presence of nitric oxide (NO), cancer-related genes become activated, leading to

Updated on:December 25,2023

Two drugs used in combination prove to be effective against most aggressive asbestos cancer in mice

byThe Spanish National Cancer Research CentreSection of a mouse invasive mesothelioma tumour. Credit: CNIOExposure to asbestos is the major risk factor for malignant mesothelioma, a type of aggr

Updated on: December 22,2023

Two drugs used in combination prove to be effective against most aggressive asbestos cancer in mice

byThe Spanish National Cancer Research CentreSection of a mouse invasive mesothelioma tumour. Credit: CNIOExposure to asbestos is the major risk factor for malignant mesothelioma, a type of aggr

Updated on:December 22,2023

Time for a 'Weed-Free January?' How cannabis users could benefit from a 'dry' month

by James MacKillop,The ConversationCredit: RDNE Stock project from PexelsBy now, most are familiar with the idea of Dry January, a voluntary month without alcohol that follows a month when many

Updated on: March 26,2024

Time for a 'Weed-Free January?' How cannabis users could benefit from a 'dry' month

by James MacKillop,The ConversationCredit: RDNE Stock project from PexelsBy now, most are familiar with the idea of Dry January, a voluntary month without alcohol that follows a month when many

Updated on:March 26,2024

A predictive biomarker of response to therapy in patients with microsatellite stable metastatic colorectal cancer

by Vall d'Hebron Institute of OncologyA total of 166 patients with mCRCBRAF-V600Ewere included in the study from discovery (n = 46), validation (n = 52) and control (n = 68) cohorts. WES of

Updated on: January 08,2024

A predictive biomarker of response to therapy in patients with microsatellite stable metastatic colorectal cancer

by Vall d'Hebron Institute of OncologyA total of 166 patients with mCRCBRAF-V600Ewere included in the study from discovery (n = 46), validation (n = 52) and control (n = 68) cohorts. WES of

Updated on:January 08,2024

Brain tumor organoids may be key to time-sensitive treatments for glioblastomas

byPerelman School of Medicine at the University of PennsylvaniaGlioblastoma (histology slide). Credit: Wikipedia/CC BY-SA 3.0Lab-grown brain organoids developed from a patient's own glioblas

Updated on: December 22,2023

Brain tumor organoids may be key to time-sensitive treatments for glioblastomas

byPerelman School of Medicine at the University of PennsylvaniaGlioblastoma (histology slide). Credit: Wikipedia/CC BY-SA 3.0Lab-grown brain organoids developed from a patient's own glioblas

Updated on:December 22,2023