Camizestrant may be superior to fulvestrant in patients with hormone receptor-positive, HER2-negative breast cancer

byAmerican Association for Cancer ResearchCredit: Pixabay/CC0 Public DomainThe next-generation selective estrogen receptor degrader (SERD) camizestrant improved progression-free survival, compar

Updated on: December 21,2023

Camizestrant may be superior to fulvestrant in patients with hormone receptor-positive, HER2-negative breast cancer

byAmerican Association for Cancer ResearchCredit: Pixabay/CC0 Public DomainThe next-generation selective estrogen receptor degrader (SERD) camizestrant improved progression-free survival, compar

Updated on:December 21,2023

An anticancer drug opens a new path for the treatment of Parkinson's

by Spanish National Research CouncilGraphical abstract. Credit:Cell Chemical Biology(2024). DOI: 10.1016/j.chembiol.2024.01.007Once they enter the body, drugs, apart from carrying out

Updated on: May 21,2024

An anticancer drug opens a new path for the treatment of Parkinson's

by Spanish National Research CouncilGraphical abstract. Credit:Cell Chemical Biology(2024). DOI: 10.1016/j.chembiol.2024.01.007Once they enter the body, drugs, apart from carrying out

Updated on:May 21,2024

Deaths from advanced lung cancer have dropped significantly since immunotherapy became standard-of-care

byWileyCredit: Unsplash/CC0 Public DomainSince the first immunotherapy drug to boost the body's immune response against advanced lung cancer was introduced in the United States in 2015, surv

Updated on: August 27,2024

Deaths from advanced lung cancer have dropped significantly since immunotherapy became standard-of-care

byWileyCredit: Unsplash/CC0 Public DomainSince the first immunotherapy drug to boost the body's immune response against advanced lung cancer was introduced in the United States in 2015, surv

Updated on:August 27,2024

First genomic study of puberty yields insights into development and cancer

by Huntsman Cancer InstituteBradley Cairns, Ph.D. Credit: Huntsman Cancer InstituteIn the first-ever genome-scale analysis of the puberty process in humans, researchers at Huntsman Cancer Institute (H

Updated on: December 20,2023

First genomic study of puberty yields insights into development and cancer

by Huntsman Cancer InstituteBradley Cairns, Ph.D. Credit: Huntsman Cancer InstituteIn the first-ever genome-scale analysis of the puberty process in humans, researchers at Huntsman Cancer Institute (H

Updated on:December 20,2023

Overexpressed Cyclin D1 and CDK4 proteins are responsible for the resistance to CDK4/6 inhibitor in some breast cancer

byScience China PressThe CDK4/6 inhibitors-resistant breast cancer cells expressed more Cyclin D1 and CDK4 proteins than the parental cells (Upper left). PI3K pathway was hyper-activated in the

Updated on: December 23,2023

Overexpressed Cyclin D1 and CDK4 proteins are responsible for the resistance to CDK4/6 inhibitor in some breast cancer

byScience China PressThe CDK4/6 inhibitors-resistant breast cancer cells expressed more Cyclin D1 and CDK4 proteins than the parental cells (Upper left). PI3K pathway was hyper-activated in the

Updated on:December 23,2023

Scientists reveal a potential new approach to treating liver cancer

byNational Institutes of Healtha, Schematic of drug screening and validation studies; MoA, mechanism of action.b, Graphs of the results from the small-molecule screen with the MIPE library

Updated on: December 27,2023

Scientists reveal a potential new approach to treating liver cancer

byNational Institutes of Healtha, Schematic of drug screening and validation studies; MoA, mechanism of action.b, Graphs of the results from the small-molecule screen with the MIPE library

Updated on:December 27,2023

Researchers find the key to genome-modifying drugs' sensitivity in malignant blood diseases

by Josep Carreras Leukaemia Research InstituteImpact of azacitidine on global DNA methylation patterns and definition of EPIAZA signature in patients with MDS. (A) Study design and workflow. (B,

Updated on: March 20,2024

Researchers find the key to genome-modifying drugs' sensitivity in malignant blood diseases

by Josep Carreras Leukaemia Research InstituteImpact of azacitidine on global DNA methylation patterns and definition of EPIAZA signature in patients with MDS. (A) Study design and workflow. (B,

Updated on:March 20,2024

Scurvy is largely a historical disease but there are signs it's making a comeback

by Lauren Ball,The ConversationCredit:Matilda Wormwood/PexelsScurvy is often considered a historical ailment, conjuring images of sailors on long sea voyages suffering from a lack of fresh

Updated on: November 13,2024

Scurvy is largely a historical disease but there are signs it's making a comeback

by Lauren Ball,The ConversationCredit:Matilda Wormwood/PexelsScurvy is often considered a historical ailment, conjuring images of sailors on long sea voyages suffering from a lack of fresh

Updated on:November 13,2024

Mechanism for silencing gene expression targets the culprit behind a deadly liver cancer

by Sanford M. Simon,Rockefeller UniversityASGR1 in FLC. (A) RNA expression analysis of ASGR1 across patient samples. (B) Immunofluorescence of ASGR1 in tumor-adjacent healthy liver, primary tumo

Updated on: March 20,2024

Mechanism for silencing gene expression targets the culprit behind a deadly liver cancer

by Sanford M. Simon,Rockefeller UniversityASGR1 in FLC. (A) RNA expression analysis of ASGR1 across patient samples. (B) Immunofluorescence of ASGR1 in tumor-adjacent healthy liver, primary tumo

Updated on:March 20,2024

New study reveals how epithelial cells in the body naturally eliminate 'precancerous' ones

by Waseda UniversityWaseda University researchers identify the underlying mechanism behind the extrusion of precancerous cells by epithelial cells, a mechanism that prevents the formation of canc

Updated on: May 07,2024

New study reveals how epithelial cells in the body naturally eliminate 'precancerous' ones

by Waseda UniversityWaseda University researchers identify the underlying mechanism behind the extrusion of precancerous cells by epithelial cells, a mechanism that prevents the formation of canc

Updated on:May 07,2024

Cancer cells hijack enhancer DNA to grow faster, study finds

University of Toronto (U of T) researchers have found that cancer cells can enhance tumor growth by hijacking enhancer DNA normally used when tissues and organs are formed. The mechanism, called enhan

Updated on: October 30,2023

Cancer cells hijack enhancer DNA to grow faster, study finds

University of Toronto (U of T) researchers have found that cancer cells can enhance tumor growth by hijacking enhancer DNA normally used when tissues and organs are formed. The mechanism, called enhan

Updated on:October 30,2023

Using SPEDOX-6 to provide targeted cancer treatment and protect heart cells

by International Society for Stem Cell ResearchSPEDOX-6 causes less damage to heart cells than dox. Left: stem cell derived heart cells treated with dox. Right: stem cell derived heart cells treated w

Updated on: January 04,2024

Using SPEDOX-6 to provide targeted cancer treatment and protect heart cells

by International Society for Stem Cell ResearchSPEDOX-6 causes less damage to heart cells than dox. Left: stem cell derived heart cells treated with dox. Right: stem cell derived heart cells treated w

Updated on:January 04,2024