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Allergy&Clinical immunology
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Retraining the immune system to treat type 1 diabetes

Retraining the immune system to treat type 1 diabetes

byUniversity of MissouriCredit:JCI Insight(2026). DOI: 10.1172/jci.insight.200686Type 1 diabetes (T1D) is a lifelong autoimmune disorder where the immune system attacks islets, certain areas of the pa

Retraining the immune system to treat type 1 diabetes

byUniversity of MissouriCredit:JCI Insight(2026). DOI: 10.1172/jci.insight.200686Type 1 diabetes (T1D) is a lifelong autoimmune disorder where the immune system attacks islets, certain areas of the pa
How cells clear immune signals could reshape drug design and cancer spread research

How cells clear immune signals could reshape drug design and cancer spread research

byUniversity of KonstanzCredit: Unsplash/CC0 Public DomainOur body receives and processes a vast number of signals. Chemical signals serve as guidance cues and ensure, for example, that immune cells a

How cells clear immune signals could reshape drug design and cancer spread research

byUniversity of KonstanzCredit: Unsplash/CC0 Public DomainOur body receives and processes a vast number of signals. Chemical signals serve as guidance cues and ensure, for example, that immune cells a
How cells fight infection from the inside: Newly identified ADX pathway may broaden understanding of immunity

How cells fight infection from the inside: Newly identified ADX pathway may broaden understanding of immunity

byCell PressSuper-resolution image of an LC3-positive autophagosome engulfing a TRIM21- and antibody-coated adenovirus. Credit: Claudia Puri, Matthew J. Gratian, Anna Albecka, and Tyler Rhinesmith.Whe

How cells fight infection from the inside: Newly identified ADX pathway may broaden understanding of immunity

byCell PressSuper-resolution image of an LC3-positive autophagosome engulfing a TRIM21- and antibody-coated adenovirus. Credit: Claudia Puri, Matthew J. Gratian, Anna Albecka, and Tyler Rhinesmith.Whe
Early immunotherapy aids in treating potentially fatal fungal pneumonias in preclinical models

Early immunotherapy aids in treating potentially fatal fungal pneumonias in preclinical models

byUniversity of Texas MD Anderson Cancer CenterHematoxylin & eosin-stained lung tissue sections according to the treatment arm, showing an absence of lymphocytic infiltrates, even in mice that rec

Early immunotherapy aids in treating potentially fatal fungal pneumonias in preclinical models

byUniversity of Texas MD Anderson Cancer CenterHematoxylin & eosin-stained lung tissue sections according to the treatment arm, showing an absence of lymphocytic infiltrates, even in mice that rec
New drug cuts relapse risk by half in rare immune disorder trial

New drug cuts relapse risk by half in rare immune disorder trial

by Sarah Williams,Stanford UniversityIn IgG4-related disease, B cells (above) attack the body's own tissue. A study led by Stanford Medicine has found that a drug reduces the chance of relapse. Cr

New drug cuts relapse risk by half in rare immune disorder trial

by Sarah Williams,Stanford UniversityIn IgG4-related disease, B cells (above) attack the body's own tissue. A study led by Stanford Medicine has found that a drug reduces the chance of relapse. Cr
T cells may be key to stopping measles virus—and its deadly relatives

T cells may be key to stopping measles virus—and its deadly relatives

byLa Jolla Institute for ImmunologyCredit: Unsplash/CC0 Public DomainT cells are some of the immune system's most important warriors. They can stop tumor growth and even fight off severe infection

T cells may be key to stopping measles virus—and its deadly relatives

byLa Jolla Institute for ImmunologyCredit: Unsplash/CC0 Public DomainT cells are some of the immune system's most important warriors. They can stop tumor growth and even fight off severe infection
Macrophages in 'marathon mode' may drive skin granulomas, pointing to new therapies

Macrophages in 'marathon mode' may drive skin granulomas, pointing to new therapies

by Uta von der Gönna, Jena UniversityCredit:Science Advances(2026). DOI: 10.1126/sciadv.aea0773An international research team has succeeded in elucidating key immunological and biochemical mechanisms

Macrophages in 'marathon mode' may drive skin granulomas, pointing to new therapies

by Uta von der Gönna, Jena UniversityCredit:Science Advances(2026). DOI: 10.1126/sciadv.aea0773An international research team has succeeded in elucidating key immunological and biochemical mechanisms
How some autoantibodies contribute to clots: The C4BP link and a path to treatment

How some autoantibodies contribute to clots: The C4BP link and a path to treatment

by Olivia Dimmer,Northwestern UniversityCredit: Pixabay/CC0 Public DomainNorthwestern Medicine investigators have uncovered a missing link behind the harmful effects of autoantibodies linked to blood

How some autoantibodies contribute to clots: The C4BP link and a path to treatment

by Olivia Dimmer,Northwestern UniversityCredit: Pixabay/CC0 Public DomainNorthwestern Medicine investigators have uncovered a missing link behind the harmful effects of autoantibodies linked to blood
Designing global flu vaccines? Studies suggest common IGHD deletions may block key antibodies

Designing global flu vaccines? Studies suggest common IGHD deletions may block key antibodies

by Felicia Lindberg,Karolinska InstitutetCredit:Immunity(2026). DOI: 10.1016/j.immuni.2026.03.002Inherited variations in antibody genes can affect how we respond to infections and vaccines, show two n

Designing global flu vaccines? Studies suggest common IGHD deletions may block key antibodies

by Felicia Lindberg,Karolinska InstitutetCredit:Immunity(2026). DOI: 10.1016/j.immuni.2026.03.002Inherited variations in antibody genes can affect how we respond to infections and vaccines, show two n
FDA approves gene therapy for severe leukocyte adhesion deficiency-I, a rare immune disorder

FDA approves gene therapy for severe leukocyte adhesion deficiency-I, a rare immune disorder

byUniversity of California, Los AngelesUCLA's Dr. Donald Kohn with Marley Gaskins and her mother, Tamara Hogue. Marley was the first patient to enroll in the LAD-l clinical trial in 2019. Credit:

FDA approves gene therapy for severe leukocyte adhesion deficiency-I, a rare immune disorder

byUniversity of California, Los AngelesUCLA's Dr. Donald Kohn with Marley Gaskins and her mother, Tamara Hogue. Marley was the first patient to enroll in the LAD-l clinical trial in 2019. Credit: