Scientists uncover key resistance mechanism to Wnt inhibitors in pancreatic and colorectal cancers

byDuke-NUS Medical SchoolDuke-NUS scientists show that FBXW7-mutant cancers are resistant to Wnt inhibitors by comparing the impact Wnt inhibitor ETC-159 has on cancer cells with and without FBX

Updated on: April 28,2024

Scientists uncover key resistance mechanism to Wnt inhibitors in pancreatic and colorectal cancers

byDuke-NUS Medical SchoolDuke-NUS scientists show that FBXW7-mutant cancers are resistant to Wnt inhibitors by comparing the impact Wnt inhibitor ETC-159 has on cancer cells with and without FBX

Updated on:April 28,2024

Study examines perceptions of benefits and risks of data sharing in dementia research

by Sam Fahmy,Georgia State UniversityCredit: Pixabay/CC0 Public DomainExpectations for data sharing among scientists and returning research results to study subjects have evolved in recent years

Updated on: April 06,2024

Study examines perceptions of benefits and risks of data sharing in dementia research

by Sam Fahmy,Georgia State UniversityCredit: Pixabay/CC0 Public DomainExpectations for data sharing among scientists and returning research results to study subjects have evolved in recent years

Updated on:April 06,2024

Patient images are missing in studies on atopic dermatitis

byUniversity of GothenburgPRISMA flow chart. PRISMA: Preferred Reporting Items for Systematic Reviews and Meta-Analyses. Credit:Journal of Dermatological Treatment(2024). DOI: 10.108

Updated on: April 28,2024

Patient images are missing in studies on atopic dermatitis

byUniversity of GothenburgPRISMA flow chart. PRISMA: Preferred Reporting Items for Systematic Reviews and Meta-Analyses. Credit:Journal of Dermatological Treatment(2024). DOI: 10.108

Updated on:April 28,2024

Diabetes drug shows promise in protecting kidneys

byOsaka Metropolitan UniversityMore red areas in the kidney indicate higher oxygen levels. Credit: Osaka Metropolitan UniversityType 2 diabetes can lead to diabetic kidney disease, but a class o

Updated on: December 04,2024

Diabetes drug shows promise in protecting kidneys

byOsaka Metropolitan UniversityMore red areas in the kidney indicate higher oxygen levels. Credit: Osaka Metropolitan UniversityType 2 diabetes can lead to diabetic kidney disease, but a class o

Updated on:December 04,2024

Mechanical constraints guide spatial pattern of glioblastoma cancer stem cells

by Shanghai Jiao Tong University Journal CenterOne photo from the article titled "Mechanical constraints in tumor guide emergent spatial patterns of glioblastoma cancer stem cells" Credit: N

Updated on: April 06,2024

Mechanical constraints guide spatial pattern of glioblastoma cancer stem cells

by Shanghai Jiao Tong University Journal CenterOne photo from the article titled "Mechanical constraints in tumor guide emergent spatial patterns of glioblastoma cancer stem cells" Credit: N

Updated on:April 06,2024

Researchers halt progression of Parkinson's disease in mouse model

NOVEMBER 14, 2023by Jacqueline Mitchell,Beth Israel Deaconess Medical CenterGeneration and characterization of Usp30 KO mice. a Schematic of gene targeting to generate the Usp30 KO mice. b Bar g

Updated on: March 28,2024

Researchers halt progression of Parkinson's disease in mouse model

NOVEMBER 14, 2023by Jacqueline Mitchell,Beth Israel Deaconess Medical CenterGeneration and characterization of Usp30 KO mice. a Schematic of gene targeting to generate the Usp30 KO mice. b Bar g

Updated on:March 28,2024

Developing standards for organ-on-a-chip research

FEBRUARY 22, 2024by Jennifer Lauren Lee,National Institute of Standards and TechnologyOrgan-on-a-chip devices use tiny structures called microfluidic channels to bring small, controlled amounts

Updated on: March 25,2024

Developing standards for organ-on-a-chip research

FEBRUARY 22, 2024by Jennifer Lauren Lee,National Institute of Standards and TechnologyOrgan-on-a-chip devices use tiny structures called microfluidic channels to bring small, controlled amounts

Updated on:March 25,2024

Analysis of research grants pipeline illustrates systematic disadvantages

FEBRUARY 21, 2024by Roger Anderson,Northwestern UniversityRate of K99 and R00 awards and conversion by year. Credit:eLife(2024). DOI: 10.7554/eLife.88984.4Of the more than 3,000 extr

Updated on: March 15,2024

Analysis of research grants pipeline illustrates systematic disadvantages

FEBRUARY 21, 2024by Roger Anderson,Northwestern UniversityRate of K99 and R00 awards and conversion by year. Credit:eLife(2024). DOI: 10.7554/eLife.88984.4Of the more than 3,000 extr

Updated on:March 15,2024

Researchers uncover genetic factors for severe Lassa fever

by Allessandra DiCorato,Broad Institute of MIT and HarvardScanning electron image of the Lassa virus budding off a cell. Credit: NIAID Integrated Research Facility (IRF) in Fort Detrick, Marylan

Updated on: March 13,2024

Researchers uncover genetic factors for severe Lassa fever

by Allessandra DiCorato,Broad Institute of MIT and HarvardScanning electron image of the Lassa virus budding off a cell. Credit: NIAID Integrated Research Facility (IRF) in Fort Detrick, Marylan

Updated on:March 13,2024

FDA Approves Lymphir: A New Hope for CTCL Patients

The U.S. Food and Drug Administration (FDA) had approved Lymphir (denileukin diftitox-cxdl), a novel immunotherapy for the treatment of relapsed or refractory cutaneous T-cell lymphoma (CTCL) after at least one prior systemic therapy.

Updated on: August 12,2024

FDA Approves Lymphir: A New Hope for CTCL Patients

The U.S. Food and Drug Administration (FDA) had approved Lymphir (denileukin diftitox-cxdl), a novel immunotherapy for the treatment of relapsed or refractory cutaneous T-cell lymphoma (CTCL) after at least one prior systemic therapy.

Updated on:August 12,2024

Removal of incorrect penicillin allergy labels by non-specialist health care professionals feasible, study shows

byUniversity of BirminghamCredit: CC0 Public DomainPatients who may have been mis-labeled as allergic to penicillin could be safely offered a dose of the oral antibiotic to demonstrate that they

Updated on: March 28,2024

Removal of incorrect penicillin allergy labels by non-specialist health care professionals feasible, study shows

byUniversity of BirminghamCredit: CC0 Public DomainPatients who may have been mis-labeled as allergic to penicillin could be safely offered a dose of the oral antibiotic to demonstrate that they

Updated on:March 28,2024

Researcher identifies key mechanism in Parkinson's disease

by Anna Zarra Aldrich,University of ConnecticutProper regulation of LRRK2 levels is important for Parkinson's disease (PD). ATIC, a purine biosynthesis pathway enzyme, and its substrate prec

Updated on: March 13,2024

Researcher identifies key mechanism in Parkinson's disease

by Anna Zarra Aldrich,University of ConnecticutProper regulation of LRRK2 levels is important for Parkinson's disease (PD). ATIC, a purine biosynthesis pathway enzyme, and its substrate prec

Updated on:March 13,2024