Dietary pyruvate targets cytosolic phospholipase A2 to mitigate inflammation and obesity in mice

by Higher Education PressThe mechanism of action of pyruvate by targeting cPLA2 and inhibiting cPLA2-mediated downstream signaling. Credit: Sadaf Hasan, Nabil Ghani, Xiangli Zhao, Julia Good, Amanda H

Updated on: July 25,2024

Dietary pyruvate targets cytosolic phospholipase A2 to mitigate inflammation and obesity in mice

by Higher Education PressThe mechanism of action of pyruvate by targeting cPLA2 and inhibiting cPLA2-mediated downstream signaling. Credit: Sadaf Hasan, Nabil Ghani, Xiangli Zhao, Julia Good, Amanda H

Updated on:July 25,2024

Study links intestinal glycan modifications to obesity and inflammation

byChiba UniversityChst4–/–mice lacking GlcNAc-6-O-sulfation of the mucinO-glycans showed significant weight gain, increased intestinal inflammation, and significantly reduced immunoglobuli

Updated on: January 18,2024

Study links intestinal glycan modifications to obesity and inflammation

byChiba UniversityChst4–/–mice lacking GlcNAc-6-O-sulfation of the mucinO-glycans showed significant weight gain, increased intestinal inflammation, and significantly reduced immunoglobuli

Updated on:January 18,2024

Mitochondria's role in diabetes: Could reversing damage offer a cure?

Updated on: March 17,2025

Mitochondria's role in diabetes: Could reversing damage offer a cure?

Updated on:March 17,2025

Lab research finds gluten causes brain inflammation in mice

byUniversity of OtagoCredit: CC0 Public DomainIn what is believed to be a world first discovery, University of Otago researchers have found that wheat gluten causes brain inflammation in mice.Th

Updated on: January 24,2024

Lab research finds gluten causes brain inflammation in mice

byUniversity of OtagoCredit: CC0 Public DomainIn what is believed to be a world first discovery, University of Otago researchers have found that wheat gluten causes brain inflammation in mice.Th

Updated on:January 24,2024

Prenatal phthalate exposure can significantly impact infant behavior and cognition, says study

by Tejas Mahadevan,Beckman Institute for Advanced Science and TechnologyCredit:Neurotoxicology and Teratology(2022). DOI: 10.1016/j.ntt.2022.107102Prenatal exposure to phthalates, a

Updated on: February 21,2024

Prenatal phthalate exposure can significantly impact infant behavior and cognition, says study

by Tejas Mahadevan,Beckman Institute for Advanced Science and TechnologyCredit:Neurotoxicology and Teratology(2022). DOI: 10.1016/j.ntt.2022.107102Prenatal exposure to phthalates, a

Updated on:February 21,2024

For diabetes and liver cancer, study suggests new screening guidelines

by Krista Conger,Stanford University Medical CenterCollagen fibers in a three-dimensional hydrogel (left panel). When advanced glycation end products—a byproduct of poorly controlled diabetes—ar

Updated on: March 14,2024

For diabetes and liver cancer, study suggests new screening guidelines

by Krista Conger,Stanford University Medical CenterCollagen fibers in a three-dimensional hydrogel (left panel). When advanced glycation end products—a byproduct of poorly controlled diabetes—ar

Updated on:March 14,2024

Parkinson's, cancer, type 2 diabetes share a key element that drives disease

by Salk InstituteParkin protein (green signal) is in a different part of the cell than the mitochondria (red signal) at time 0 (left image) but then co-localizes with the mitochondria after 60 mi

Updated on: February 19,2024

Parkinson's, cancer, type 2 diabetes share a key element that drives disease

by Salk InstituteParkin protein (green signal) is in a different part of the cell than the mitochondria (red signal) at time 0 (left image) but then co-localizes with the mitochondria after 60 mi

Updated on:February 19,2024

Unravelling the mysteries around type 2 diabetes

by University of LeedsCredit: CC0 Public DomainFor more than 30 years, scientists have been trying to unravel the mystery of how a key biological molecule self assembles into a rogue protein-like

Updated on: February 05,2024

Unravelling the mysteries around type 2 diabetes

by University of LeedsCredit: CC0 Public DomainFor more than 30 years, scientists have been trying to unravel the mystery of how a key biological molecule self assembles into a rogue protein-like

Updated on:February 05,2024

Cells can use uridine, a component of RNA, as a source of energy

by Allessandra DiCorato,Broad Institute of MIT and HarvardCredit: Sonja Vasiljeva, Broad CommunicationsOur bodies burn carbohydrates, proteins, and fat for fuel, and now, researchers at the Broa

Updated on: February 19,2024

Cells can use uridine, a component of RNA, as a source of energy

by Allessandra DiCorato,Broad Institute of MIT and HarvardCredit: Sonja Vasiljeva, Broad CommunicationsOur bodies burn carbohydrates, proteins, and fat for fuel, and now, researchers at the Broa

Updated on:February 19,2024

Researchers identify molecular mechanism by which key protein regulates LDL cholesterol

by University of MontrealCredit: CC0 Public DomainIn a crucial step towards understanding the mechanisms involved in cardiovascular disease and certain cancers, a Canadian led research team has s

Updated on: February 19,2024

Researchers identify molecular mechanism by which key protein regulates LDL cholesterol

by University of MontrealCredit: CC0 Public DomainIn a crucial step towards understanding the mechanisms involved in cardiovascular disease and certain cancers, a Canadian led research team has s

Updated on:February 19,2024

New research sheds light on transcription stimulated by estrogen receptor-α

by Molly Chiu,Baylor College of MedicineGraphical abstract. Credit: DOI: 10.1016/j.isci.2021.103227Gene expression is a highly regulated sequence with many players, one being the estrogen recept

Updated on: February 21,2024

New research sheds light on transcription stimulated by estrogen receptor-α

by Molly Chiu,Baylor College of MedicineGraphical abstract. Credit: DOI: 10.1016/j.isci.2021.103227Gene expression is a highly regulated sequence with many players, one being the estrogen recept

Updated on:February 21,2024

Obesity may lead to a decline in lung function in premenopausal and postmenopausal women

by The North American Menopause SocietyCredit: Unsplash/CC0 Public DomainObesity has been linked to a wide array of health problems. A new study suggests that abdominal obesity as measured by bod

Updated on: January 31,2024

Obesity may lead to a decline in lung function in premenopausal and postmenopausal women

by The North American Menopause SocietyCredit: Unsplash/CC0 Public DomainObesity has been linked to a wide array of health problems. A new study suggests that abdominal obesity as measured by bod

Updated on:January 31,2024