New method is better able to map immune response and paves way for new treatments

byKarolinska InstitutetSpatial transcriptomics–based method to map B cell and T cell receptors.Targeted capture of antigen receptor sequences from spatial transcriptomics gene expression librari

Updated on: January 26,2024 17

New method is better able to map immune response and paves way for new treatments

byKarolinska InstitutetSpatial transcriptomics–based method to map B cell and T cell receptors.Targeted capture of antigen receptor sequences from spatial transcriptomics gene expression librari

Updated on:January 26,2024 17

Mathematical dermatology: Unraveling the mechanism of urticaria from eruption shapes

by Institute for the Advanced Study of Human Biology (ASHBI)In vivo pathophysiological network of chronic spontaneous urticaria (CSU). Credit:Communications Medicine(2023). DOI: 10.1038/s4

Updated on: January 26,2024 22

Mathematical dermatology: Unraveling the mechanism of urticaria from eruption shapes

by Institute for the Advanced Study of Human Biology (ASHBI)In vivo pathophysiological network of chronic spontaneous urticaria (CSU). Credit:Communications Medicine(2023). DOI: 10.1038/s4

Updated on:January 26,2024 22

How an immune response is driven by one letter difference in DNA

byRadboud UniversityA biphasic circuit regulates IL-1β and IL-37 expression to coordinate pro- and anti-inflammatory processes from within a single TAD. The two functionally opposed states of th

Updated on: January 26,2024 23

How an immune response is driven by one letter difference in DNA

byRadboud UniversityA biphasic circuit regulates IL-1β and IL-37 expression to coordinate pro- and anti-inflammatory processes from within a single TAD. The two functionally opposed states of th

Updated on:January 26,2024 23

Mettl3-dependent m6A modification is essential for effector differentiation and memory formation of CD8+ T cells

byScience China PressDuring viral infection, total m6A levels in Naïve stage, effector stage, and memory stage exhibit dynamic alteration (high-low-high). The presence of Mettl3 promotes CD8 T c

Updated on: January 26,2024 19

Mettl3-dependent m6A modification is essential for effector differentiation and memory formation of CD8+ T cells

byScience China PressDuring viral infection, total m6A levels in Naïve stage, effector stage, and memory stage exhibit dynamic alteration (high-low-high). The presence of Mettl3 promotes CD8 T c

Updated on:January 26,2024 19

Researchers redesign future mRNA therapeutics to prevent potentially harmful immune responses

byUniversity of CambridgeBiochemist Professor Anne Willis and immunologist Dr James Thaventhiran at the MRC Toxicology Unit at the University of Cambridge led this work. Credit: Mike Thornton, S

Updated on: January 26,2024 17

Researchers redesign future mRNA therapeutics to prevent potentially harmful immune responses

byUniversity of CambridgeBiochemist Professor Anne Willis and immunologist Dr James Thaventhiran at the MRC Toxicology Unit at the University of Cambridge led this work. Credit: Mike Thornton, S

Updated on:January 26,2024 17

Researchers reveal molecular mechanism of cytokine storm induced by coronavirus

by Zhang Nannan,Chinese Academy of SciencesSARS-CoV-2 stabilizes host mRNAs to induce cytokine storm. Credit: Xue Yuanchao's groupIn the past four years, the pathogen responsible for Coronav

Updated on: January 26,2024 21

Researchers reveal molecular mechanism of cytokine storm induced by coronavirus

by Zhang Nannan,Chinese Academy of SciencesSARS-CoV-2 stabilizes host mRNAs to induce cytokine storm. Credit: Xue Yuanchao's groupIn the past four years, the pathogen responsible for Coronav

Updated on:January 26,2024 21

Discovery unveils immune system's guardian: Ikaros

byMonash UniversityCredit: Pixabay/CC0 Public DomainIn a scientific breakthrough that aids our understanding of the internal wiring of immune cells, researchers at Monash University in Australia

Updated on: January 26,2024 20

Discovery unveils immune system's guardian: Ikaros

byMonash UniversityCredit: Pixabay/CC0 Public DomainIn a scientific breakthrough that aids our understanding of the internal wiring of immune cells, researchers at Monash University in Australia

Updated on:January 26,2024 20

Study offers new insights into how immune cells recognize their enemies

by Gunnar Bartsch,Julius-Maximilians-Universität WürzburgPAg induced Vγ9Vδ2 T cell activation by BTN3A-BTN2A1 composite ligand. Credit:Nature Communications(2023). DOI: 10.1038/s4146

Updated on: January 26,2024 12

Study offers new insights into how immune cells recognize their enemies

by Gunnar Bartsch,Julius-Maximilians-Universität WürzburgPAg induced Vγ9Vδ2 T cell activation by BTN3A-BTN2A1 composite ligand. Credit:Nature Communications(2023). DOI: 10.1038/s4146

Updated on:January 26,2024 12

Scientists solve 18-year-old mystery and find the once-elusive source of a critical T cell population

by Delthia Ricks , Medical XpressPresence of Tcf7+CD8+T cells during the primary response to infection. (A) Experimental schematic: Naïve P14 cells (CD45.2) were transferred into congenica

Updated on: January 26,2024 17

Scientists solve 18-year-old mystery and find the once-elusive source of a critical T cell population

by Delthia Ricks , Medical XpressPresence of Tcf7+CD8+T cells during the primary response to infection. (A) Experimental schematic: Naïve P14 cells (CD45.2) were transferred into congenica

Updated on:January 26,2024 17

This gross mixture has big benefits for the study of bacteria

byUniversity of MichiganDetermining the bottleneck of infection forP. mirabilisduring UTI. (A–C) CBA/J mice were transurethrally inoculated with 107CFU. The inoculum contained

Updated on: January 25,2024 17

This gross mixture has big benefits for the study of bacteria

byUniversity of MichiganDetermining the bottleneck of infection forP. mirabilisduring UTI. (A–C) CBA/J mice were transurethrally inoculated with 107CFU. The inoculum contained

Updated on:January 25,2024 17

Hope for autoimmune skin disorder sufferers with new immunotherapy strategy

byThe Peter Doherty Institute for Infection and ImmunityCredit: Estzer Miller on PixabayBreakthrough research has revealed new ways to remove immune cells that cause skin autoimmune diseases wit

Updated on: January 25,2024 23

Hope for autoimmune skin disorder sufferers with new immunotherapy strategy

byThe Peter Doherty Institute for Infection and ImmunityCredit: Estzer Miller on PixabayBreakthrough research has revealed new ways to remove immune cells that cause skin autoimmune diseases wit

Updated on:January 25,2024 23

Researchers show that an influx of water and salts propel immune cells through the body

byThe Francis Crick InstituteCredit: Pixabay/CC0 Public DomainResearchers at the Francis Crick Institute, working with Imperial College London, King's College London and University of Cambri

Updated on: January 25,2024 15

Researchers show that an influx of water and salts propel immune cells through the body

byThe Francis Crick InstituteCredit: Pixabay/CC0 Public DomainResearchers at the Francis Crick Institute, working with Imperial College London, King's College London and University of Cambri

Updated on:January 25,2024 15