Researchers redesign future mRNA therapeutics to prevent potentially harmful immune responses

byUniversity of CambridgeBiochemist Professor Anne Willis and immunologist Dr James Thaventhiran at the MRC Toxicology Unit at the University of Cambridge led this work. Credit: Mike Thornton, S

Updated on: January 26,2024 17

Researchers redesign future mRNA therapeutics to prevent potentially harmful immune responses

byUniversity of CambridgeBiochemist Professor Anne Willis and immunologist Dr James Thaventhiran at the MRC Toxicology Unit at the University of Cambridge led this work. Credit: Mike Thornton, S

Updated on:January 26,2024 17

Mettl3-dependent m6A modification is essential for effector differentiation and memory formation of CD8+ T cells

byScience China PressDuring viral infection, total m6A levels in Naïve stage, effector stage, and memory stage exhibit dynamic alteration (high-low-high). The presence of Mettl3 promotes CD8 T c

Updated on: January 26,2024 19

Mettl3-dependent m6A modification is essential for effector differentiation and memory formation of CD8+ T cells

byScience China PressDuring viral infection, total m6A levels in Naïve stage, effector stage, and memory stage exhibit dynamic alteration (high-low-high). The presence of Mettl3 promotes CD8 T c

Updated on:January 26,2024 19

How an immune response is driven by one letter difference in DNA

byRadboud UniversityA biphasic circuit regulates IL-1β and IL-37 expression to coordinate pro- and anti-inflammatory processes from within a single TAD. The two functionally opposed states of th

Updated on: January 26,2024 23

How an immune response is driven by one letter difference in DNA

byRadboud UniversityA biphasic circuit regulates IL-1β and IL-37 expression to coordinate pro- and anti-inflammatory processes from within a single TAD. The two functionally opposed states of th

Updated on:January 26,2024 23

Mathematical dermatology: Unraveling the mechanism of urticaria from eruption shapes

by Institute for the Advanced Study of Human Biology (ASHBI)In vivo pathophysiological network of chronic spontaneous urticaria (CSU). Credit:Communications Medicine(2023). DOI: 10.1038/s4

Updated on: January 26,2024 22

Mathematical dermatology: Unraveling the mechanism of urticaria from eruption shapes

by Institute for the Advanced Study of Human Biology (ASHBI)In vivo pathophysiological network of chronic spontaneous urticaria (CSU). Credit:Communications Medicine(2023). DOI: 10.1038/s4

Updated on:January 26,2024 22

New method is better able to map immune response and paves way for new treatments

byKarolinska InstitutetSpatial transcriptomics–based method to map B cell and T cell receptors.Targeted capture of antigen receptor sequences from spatial transcriptomics gene expression librari

Updated on: January 26,2024 17

New method is better able to map immune response and paves way for new treatments

byKarolinska InstitutetSpatial transcriptomics–based method to map B cell and T cell receptors.Targeted capture of antigen receptor sequences from spatial transcriptomics gene expression librari

Updated on:January 26,2024 17

New study uncovers molecular interactions driving multiple inflammasome activation and inflammatory cell death

by JooHyeon Heo,Ulsan National Institute of Science and TechnologyThe formation of panoptosomes and inflammatory apoptosis following the injection of four pathogen-related patterns. Credit:&nbsp

Updated on: January 26,2024 12

New study uncovers molecular interactions driving multiple inflammasome activation and inflammatory cell death

by JooHyeon Heo,Ulsan National Institute of Science and TechnologyThe formation of panoptosomes and inflammatory apoptosis following the injection of four pathogen-related patterns. Credit:&nbsp

Updated on:January 26,2024 12

Review highlights the challenges and recent advances in targeted therapies for lupus nephritis

by Cactus CommunicationsSLE involves abnormal activation of both innate and adaptive immune responses, leading to systemic immune dysregulation and renal impairment. The complement system's dysfun

Updated on: January 26,2024 13

Review highlights the challenges and recent advances in targeted therapies for lupus nephritis

by Cactus CommunicationsSLE involves abnormal activation of both innate and adaptive immune responses, leading to systemic immune dysregulation and renal impairment. The complement system's dysfun

Updated on:January 26,2024 13

Q&A: Why 'Jack Frost' may spoil winter plans for some with autoimmune diseases

by Laura Kelley,CU Anschutz Medical CampusCredit: Pixabay/CC0 Public DomainMost Coloradans look at winter as a time of excitement when the high country turns into our own winter wonderland with

Updated on: January 26,2024 11

Q&A: Why 'Jack Frost' may spoil winter plans for some with autoimmune diseases

by Laura Kelley,CU Anschutz Medical CampusCredit: Pixabay/CC0 Public DomainMost Coloradans look at winter as a time of excitement when the high country turns into our own winter wonderland with

Updated on:January 26,2024 11

Updated guidelines released for management of atopic dermatitis

by Elana GotkineIn updated guidelines issued by the American Academy of Allergy, Asthma and Immunology/American College of Allergy, Asthma and Immunology, and published online Dec. 17 in theAnna

Updated on: January 26,2024 24

Updated guidelines released for management of atopic dermatitis

by Elana GotkineIn updated guidelines issued by the American Academy of Allergy, Asthma and Immunology/American College of Allergy, Asthma and Immunology, and published online Dec. 17 in theAnna

Updated on:January 26,2024 24

FDA wants more data on first needle-free antidote for severe allergic reactions

by Denise MannIn a surprising move, the U.S. Food and Drug Administration (FDA) has opted not to approve a needle-free alternative to the EpiPen for emergency treatment of severe allergic reactions.Ap

Updated on: January 27,2024 12

FDA wants more data on first needle-free antidote for severe allergic reactions

by Denise MannIn a surprising move, the U.S. Food and Drug Administration (FDA) has opted not to approve a needle-free alternative to the EpiPen for emergency treatment of severe allergic reactions.Ap

Updated on:January 27,2024 12

Updated systemic lupus erythematosus management recommendations

by EULARCredit: Pixabay/CC0 Public DomainSystemic lupus erythematosus (SLE) is a heterogeneous disease, which can cause many different manifestations and symptoms, and traditionally did not have many

Updated on: January 27,2024 11

Updated systemic lupus erythematosus management recommendations

by EULARCredit: Pixabay/CC0 Public DomainSystemic lupus erythematosus (SLE) is a heterogeneous disease, which can cause many different manifestations and symptoms, and traditionally did not have many

Updated on:January 27,2024 11

How two proteins that bind to RNA contribute to the inflammation of asthma

by King's College LondonCredit: Pixabay/CC0 Public DomainA publication inFrontiers in Cell and Developmental Biologyled by researchers from King's College London has, for the

Updated on: January 28,2024 20

How two proteins that bind to RNA contribute to the inflammation of asthma

by King's College LondonCredit: Pixabay/CC0 Public DomainA publication inFrontiers in Cell and Developmental Biologyled by researchers from King's College London has, for the

Updated on:January 28,2024 20