The secret lives of T cells: They derive energy from a master regulator that has been poorly understood, until now

by Delthia Ricks , Medical XpressIn vitro modeling of Teff STAT5 responses. (A) WT CD4+ T cells were cultured with or without blocking anti-mouse IL-2/IL-2R antibodies and/or human IL-2. Flow cytometr

Updated on: May 06,2024

The secret lives of T cells: They derive energy from a master regulator that has been poorly understood, until now

by Delthia Ricks , Medical XpressIn vitro modeling of Teff STAT5 responses. (A) WT CD4+ T cells were cultured with or without blocking anti-mouse IL-2/IL-2R antibodies and/or human IL-2. Flow cytometr

Updated on:May 06,2024

Warfarin use significantly increases risk of knee and hip replacement in people with OA

by American College of RheumatologyCredit: CC0 Public DomainNew research presented at ACR Convergence, the American College of Rheumatology's annual meeting, shows that use of warfarin, a vit

Updated on: May 23,2024

Warfarin use significantly increases risk of knee and hip replacement in people with OA

by American College of RheumatologyCredit: CC0 Public DomainNew research presented at ACR Convergence, the American College of Rheumatology's annual meeting, shows that use of warfarin, a vit

Updated on:May 23,2024

Suppressing graft-versus-host disease using immunosuppressive iPS cell-derived regulatory T cells

by Kyoto UniversityGraphical abstract. Credit:Cell Stem Cell(2024). DOI: 10.1016/j.stem.2024.05.004A recent study by a team led by Professor Shin Kaneko successfully induced regulator

Updated on: June 15,2024

Suppressing graft-versus-host disease using immunosuppressive iPS cell-derived regulatory T cells

by Kyoto UniversityGraphical abstract. Credit:Cell Stem Cell(2024). DOI: 10.1016/j.stem.2024.05.004A recent study by a team led by Professor Shin Kaneko successfully induced regulator

Updated on:June 15,2024

Mast cell levels may explain sex differences in osteoarthritis pain

by Hospital for Special SurgeryCredit: Pixabay/CC0 Public DomainInvestigators at Hospital for Special Surgery (HSS) have discovered that at the time of total knee replacement, women have signific

Updated on: April 17,2024

Mast cell levels may explain sex differences in osteoarthritis pain

by Hospital for Special SurgeryCredit: Pixabay/CC0 Public DomainInvestigators at Hospital for Special Surgery (HSS) have discovered that at the time of total knee replacement, women have signific

Updated on:April 17,2024

How a COVID-19 infection spurs antibodies against common colds

by The Scripps Research InstituteResearchers analyzed the structures of antibodies (colored) from healthy donors as the molecules bound to the spike protein from common coronaviruses like OC43 (s

Updated on: April 10,2024

How a COVID-19 infection spurs antibodies against common colds

by The Scripps Research InstituteResearchers analyzed the structures of antibodies (colored) from healthy donors as the molecules bound to the spike protein from common coronaviruses like OC43 (s

Updated on:April 10,2024

m6A mRNA modification potentiates Th17 functions to inflame autoimmunity

by Science China PressLoss of METTL3 in Th17 cells facilitated SOCS family RNA stability, inhibited IL-6/STAT3 mediated IL-17A and CCR5 expression, which in turn impeding Th17 cells differentiati

Updated on: April 16,2024

m6A mRNA modification potentiates Th17 functions to inflame autoimmunity

by Science China PressLoss of METTL3 in Th17 cells facilitated SOCS family RNA stability, inhibited IL-6/STAT3 mediated IL-17A and CCR5 expression, which in turn impeding Th17 cells differentiati

Updated on:April 16,2024

Does body mass index impact pain in individuals with hand osteoarthritis?

by WileyCredit: Unsplash/CC0 Public DomainIn a study inArthritis & Rheumatologyof people with hand osteoarthritis, higher body mass index was associated with greater pain severity

Updated on: June 15,2024

Does body mass index impact pain in individuals with hand osteoarthritis?

by WileyCredit: Unsplash/CC0 Public DomainIn a study inArthritis & Rheumatologyof people with hand osteoarthritis, higher body mass index was associated with greater pain severity

Updated on:June 15,2024

Survival improving after hip and knee replacement

(HealthDay)—Short-term survival after elective total hip (THR) and total knee replacement (TKR) has greatly improved since the early 1990s, even though comorbidities have increased, according to a stu

Updated on: April 08,2024

Survival improving after hip and knee replacement

(HealthDay)—Short-term survival after elective total hip (THR) and total knee replacement (TKR) has greatly improved since the early 1990s, even though comorbidities have increased, according to a stu

Updated on:April 08,2024

Study aims to unravel the genetic causes of osteoarthritis

by Wellcome Trust Sanger InstituteA hip with osteoarthritis. In an X-ray of a healthy hip, the heads of the hip bone have smooth, evenly curved surfaces and there is a 'gap' between the h

Updated on: March 28,2024

Study aims to unravel the genetic causes of osteoarthritis

by Wellcome Trust Sanger InstituteA hip with osteoarthritis. In an X-ray of a healthy hip, the heads of the hip bone have smooth, evenly curved surfaces and there is a 'gap' between the h

Updated on:March 28,2024

Anaphylaxis treatment remains confusing for patients, caregivers and emergency personnel, research finds

byAmerican College of Allergy, Asthma, and ImmunologyCredit: Unsplash/CC0 Public DomainAnaphylaxis can come on suddenly and without warning, and because its symptoms can be fatal, it is scary fo

Updated on: November 01,2024

Anaphylaxis treatment remains confusing for patients, caregivers and emergency personnel, research finds

byAmerican College of Allergy, Asthma, and ImmunologyCredit: Unsplash/CC0 Public DomainAnaphylaxis can come on suddenly and without warning, and because its symptoms can be fatal, it is scary fo

Updated on:November 01,2024

NIH should create an Office of Autoimmune Disease Research, says new report

by National Academies of Sciences, Engineering, and MedicineCredit: Pixabay/CC0 Public DomainWhile the quantity and quality of research that the National Institutes of Health (NIH) conducts on autoimm

Updated on: May 05,2024

NIH should create an Office of Autoimmune Disease Research, says new report

by National Academies of Sciences, Engineering, and MedicineCredit: Pixabay/CC0 Public DomainWhile the quantity and quality of research that the National Institutes of Health (NIH) conducts on autoimm

Updated on:May 05,2024

TLK protein inhibition activates the innate immune system

by Institute for Research in Biomedicine - IRBCancer cells with TLK inhibition show replication intermediates (green) at chromosome ends (red). Credit: IRB BarcelonaTousled-like kinases (TLKs) are a p

Updated on: April 24,2024

TLK protein inhibition activates the innate immune system

by Institute for Research in Biomedicine - IRBCancer cells with TLK inhibition show replication intermediates (green) at chromosome ends (red). Credit: IRB BarcelonaTousled-like kinases (TLKs) are a p

Updated on:April 24,2024