Cryo-EM imaging of STING protein reveals new binding pocket

by UniversityofTexasSouthwesternMedicalCenterThe synthetic drug-like compound (magenta spheres at the bottom) targets a hidden pocket in STING. This pocket is located at

Updated on: May 07,2024

Cryo-EM imaging of STING protein reveals new binding pocket

by UniversityofTexasSouthwesternMedicalCenterThe synthetic drug-like compound (magenta spheres at the bottom) targets a hidden pocket in STING. This pocket is located at

Updated on:May 07,2024

Is metabolic syndrome a modifiable risk factor for gout?

by WileyCredit: Pixabay/CC0 Public DomainIn a study published inArthritis & Rheumatologythat included nearly 1.3 million men aged 20–39 years who participated in three serial heal

Updated on: June 01,2024

Is metabolic syndrome a modifiable risk factor for gout?

by WileyCredit: Pixabay/CC0 Public DomainIn a study published inArthritis & Rheumatologythat included nearly 1.3 million men aged 20–39 years who participated in three serial heal

Updated on:June 01,2024

RA linked to restrictive, obstructive spirometry patterns

(HealthDay)—Rheumatoid arthritis (RA) is associated with restrictive and obstructive spirometry patterns, with the strongest associations seen for severe patterns, according to a study published onlin

Updated on: June 01,2024

RA linked to restrictive, obstructive spirometry patterns

(HealthDay)—Rheumatoid arthritis (RA) is associated with restrictive and obstructive spirometry patterns, with the strongest associations seen for severe patterns, according to a study published onlin

Updated on:June 01,2024

X chromosome gene may explain why women are more prone to autoimmune diseases

by Alice Walton,University of California, Los Angeles(A) Using the high-throughput sequencing approach, sexually biased X chromosome genes in CD4+T cells were determined for C57BL/6J naive

Updated on: May 05,2024

X chromosome gene may explain why women are more prone to autoimmune diseases

by Alice Walton,University of California, Los Angeles(A) Using the high-throughput sequencing approach, sexually biased X chromosome genes in CD4+T cells were determined for C57BL/6J naive

Updated on:May 05,2024

Preclinical study of COVID-19 vaccine candidate shows potent T-cell responses

by University of Alabama at BirminghamCredit: University of Alabama at BirminghamPreclinical studies of a COVID-19 vaccine candidate at the University of Alabama at Birmingham show positive resul

Updated on: April 10,2024

Preclinical study of COVID-19 vaccine candidate shows potent T-cell responses

by University of Alabama at BirminghamCredit: University of Alabama at BirminghamPreclinical studies of a COVID-19 vaccine candidate at the University of Alabama at Birmingham show positive resul

Updated on:April 10,2024

Exercise training improves cardiac parameters in lupus

(HealthDay) -- For inactive patients with systemic lupus erythematosus (SLE), a three-month exercise training program is associated with improved chronotropic reserve and heart rate recovery, accordin

Updated on: March 24,2024

Exercise training improves cardiac parameters in lupus

(HealthDay) -- For inactive patients with systemic lupus erythematosus (SLE), a three-month exercise training program is associated with improved chronotropic reserve and heart rate recovery, accordin

Updated on:March 24,2024

Study investigates rates of adverse events for common rheumatoid arthritis drug

by Brigham and Women's HospitalCredit: CC0 Public DomainMethotrexate is a common drug with a long history; for the past 40 years, it's been used to treat a range of diseases. Today it is

Updated on: June 17,2024

Study investigates rates of adverse events for common rheumatoid arthritis drug

by Brigham and Women's HospitalCredit: CC0 Public DomainMethotrexate is a common drug with a long history; for the past 40 years, it's been used to treat a range of diseases. Today it is

Updated on:June 17,2024

Novel study identifies key molecular players in rheumatoid arthritis

by University of California - San DiegoAn x-ray depicts a hand fully affected by rheumatoid arthritis, which is characterized by swollen, painful joints, most commonly involving the wrists and ha

Updated on: June 15,2024

Novel study identifies key molecular players in rheumatoid arthritis

by University of California - San DiegoAn x-ray depicts a hand fully affected by rheumatoid arthritis, which is characterized by swollen, painful joints, most commonly involving the wrists and ha

Updated on:June 15,2024

Study examines care for knee replacement patients at physical therapy facilities

by WileyCredit: CC0 Public DomainIn an analysis of 112 records from 30 physical therapy (PT) sites regarding care for patients who had undergone total knee replacement (TKR) surgery, investigator

Updated on: April 17,2024

Study examines care for knee replacement patients at physical therapy facilities

by WileyCredit: CC0 Public DomainIn an analysis of 112 records from 30 physical therapy (PT) sites regarding care for patients who had undergone total knee replacement (TKR) surgery, investigator

Updated on:April 17,2024

Unique immune response found in patients who experience inflammatory arthritis as side effect of cancer therapies

by Brigham and Women's HospitalMultiplexed immunofluorescence of synovial tissue. Multiplexed immunofluorescence images showing an example of a Ki67+PD-1+synovial CD8 T cell (white arro

Updated on: July 03,2024

Unique immune response found in patients who experience inflammatory arthritis as side effect of cancer therapies

by Brigham and Women's HospitalMultiplexed immunofluorescence of synovial tissue. Multiplexed immunofluorescence images showing an example of a Ki67+PD-1+synovial CD8 T cell (white arro

Updated on:July 03,2024

Breast-feeding might reduce moms' odds of rheumatoid arthritis

Study in China finds risk cut nearly in half after nursing.(HealthDay)—Women who breast-feed may have a lower risk of developing rheumatoid arthritis later in life, new research suggests.Researchers a

Updated on: March 24,2024

Breast-feeding might reduce moms' odds of rheumatoid arthritis

Study in China finds risk cut nearly in half after nursing.(HealthDay)—Women who breast-feed may have a lower risk of developing rheumatoid arthritis later in life, new research suggests.Researchers a

Updated on:March 24,2024

Study in mice shows alterations in X-chromosome inactivation predispose female mammals to autoimmune disease

by Bob Yirka , Medical XpressPerturbation of X-inactivation in immune cells ofFtx−/−females.(A) Map of the X inactivation center showing the location ofXist(green) andFtx

Updated on: May 30,2024

Study in mice shows alterations in X-chromosome inactivation predispose female mammals to autoimmune disease

by Bob Yirka , Medical XpressPerturbation of X-inactivation in immune cells ofFtx−/−females.(A) Map of the X inactivation center showing the location ofXist(green) andFtx

Updated on:May 30,2024