Evolutionary study links subtle modifications in the morphology of the bipedal knee to osteoarthritis later in life

by Harvard UniversityA visual riff on the classic illustration, "March of Progress," highlighting the evolution of knee osteoarthritis. Credit: Tasha McAbee, Department of Orthopedics a

Updated on: May 08,2024

Evolutionary study links subtle modifications in the morphology of the bipedal knee to osteoarthritis later in life

by Harvard UniversityA visual riff on the classic illustration, "March of Progress," highlighting the evolution of knee osteoarthritis. Credit: Tasha McAbee, Department of Orthopedics a

Updated on:May 08,2024

How changing gut microbiota can affect lupus disease activity in mice

by The Ohio State UniversityFigure 1. NZM2410 colonized with SFB exhibit intensified kidney disease with elevated immune-complex deposition. 10-week old mice were oral gavaged with fecal matter f

Updated on: June 20,2024

How changing gut microbiota can affect lupus disease activity in mice

by The Ohio State UniversityFigure 1. NZM2410 colonized with SFB exhibit intensified kidney disease with elevated immune-complex deposition. 10-week old mice were oral gavaged with fecal matter f

Updated on:June 20,2024

Post-COVID-19 conditions alter a person's immune response

by Cedars-Sinai Medical CenterCredit: Unsplash/CC0 Public DomainA new study by investigators from the Smidt Heart Institute at Cedars-Sinai suggests long COVID-19 might be caused by a dysfunction

Updated on: April 09,2024

Post-COVID-19 conditions alter a person's immune response

by Cedars-Sinai Medical CenterCredit: Unsplash/CC0 Public DomainA new study by investigators from the Smidt Heart Institute at Cedars-Sinai suggests long COVID-19 might be caused by a dysfunction

Updated on:April 09,2024

Enzyme-activating antibodies revealed as marker for most severe form of rheumatoid arthritis

by Johns Hopkins University School of MedicineThe proposed binding site of the PAD4-activating antibody. The PAD4 enzyme is composed of two pieces (light gray and dark gray) that are connected in

Updated on: June 06,2024

Enzyme-activating antibodies revealed as marker for most severe form of rheumatoid arthritis

by Johns Hopkins University School of MedicineThe proposed binding site of the PAD4-activating antibody. The PAD4 enzyme is composed of two pieces (light gray and dark gray) that are connected in

Updated on:June 06,2024

How intravenous immunoglobulin antibodies resolve joint inflammation in rheumatoid arthritis

by Friedrich–Alexander University Erlangen–NurnbergGraphical abstract. Credit:Immunity(2023). DOI: 10.1016/j.immuni.2023.02.019Immunoglobulin G antibodies (IgB) play an important role

Updated on: June 17,2024

How intravenous immunoglobulin antibodies resolve joint inflammation in rheumatoid arthritis

by Friedrich–Alexander University Erlangen–NurnbergGraphical abstract. Credit:Immunity(2023). DOI: 10.1016/j.immuni.2023.02.019Immunoglobulin G antibodies (IgB) play an important role

Updated on:June 17,2024

Weekly leflunomide effective for early rheumatoid arthritis

(HealthDay)—A higher, weekly dose of leflunomide shows similar benefits to a daily dose for the treatment of mild-to-moderate early rheumatoid arthritis (ERA), according to a study published online Au

Updated on: April 08,2024

Weekly leflunomide effective for early rheumatoid arthritis

(HealthDay)—A higher, weekly dose of leflunomide shows similar benefits to a daily dose for the treatment of mild-to-moderate early rheumatoid arthritis (ERA), according to a study published online Au

Updated on:April 08,2024

Targeting ion channels to manage osteoarthritis pain

by Melissa Rohman,Northwestern UniversityThe image depicts two drug receptor sites with the molecular structure of the Nav1.7 channel, and tamoxifen’s attenuation of nociceptor action potentials

Updated on: May 14,2024

Targeting ion channels to manage osteoarthritis pain

by Melissa Rohman,Northwestern UniversityThe image depicts two drug receptor sites with the molecular structure of the Nav1.7 channel, and tamoxifen’s attenuation of nociceptor action potentials

Updated on:May 14,2024

Biomarkers may ID rheumatoid arthritis patients with and without active disease

Neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) values may differentiate between rheumatoid arthritis (RA) patients with and without active disease, according to a systemat

Updated on: May 29,2024

Biomarkers may ID rheumatoid arthritis patients with and without active disease

Neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) values may differentiate between rheumatoid arthritis (RA) patients with and without active disease, according to a systemat

Updated on:May 29,2024

Gender, high DAS28-P index predictive of pain in early RA

(HealthDay) -- For patients with rheumatoid arthritis (RA), female gender and having a high proportion of disease activity score (DAS28) attributable to patient-reported components (joint tenderness a

Updated on: April 08,2024

Gender, high DAS28-P index predictive of pain in early RA

(HealthDay) -- For patients with rheumatoid arthritis (RA), female gender and having a high proportion of disease activity score (DAS28) attributable to patient-reported components (joint tenderness a

Updated on:April 08,2024

A small mutation can make Zika virus even more dangerous

by La Jolla Institute for ImmunologyRepeatedly switching back and forth between mosquito cells and mice provided scientists with a window into how Zika virus naturally evolves as it encounters mo

Updated on: April 24,2024

A small mutation can make Zika virus even more dangerous

by La Jolla Institute for ImmunologyRepeatedly switching back and forth between mosquito cells and mice provided scientists with a window into how Zika virus naturally evolves as it encounters mo

Updated on:April 24,2024

Novel mechanism of ILC2 immune cell development may be involved in exacerbating allergic diseases

byChiba UniversityResearchers identify a G3SE-dependent mechanism of ILC2 development. Credit: Yosuke Toda and Arifumi Iwata from Chiba UniversityOverproduction of Group 2 innate lymphoid cells

Updated on: July 11,2024

Novel mechanism of ILC2 immune cell development may be involved in exacerbating allergic diseases

byChiba UniversityResearchers identify a G3SE-dependent mechanism of ILC2 development. Credit: Yosuke Toda and Arifumi Iwata from Chiba UniversityOverproduction of Group 2 innate lymphoid cells

Updated on:July 11,2024

Omega-3s could boost immunotherapy's cancer-fighting power

by Experimental BiologyOmega-3 supplementation improves the efficacy of immunotherapy in subcutaneous murine MB49 bladder cancer tumors. Credit: Abigail Kelly, Beth Israel Deaconess Medical Center/Har

Updated on: April 20,2024

Omega-3s could boost immunotherapy's cancer-fighting power

by Experimental BiologyOmega-3 supplementation improves the efficacy of immunotherapy in subcutaneous murine MB49 bladder cancer tumors. Credit: Abigail Kelly, Beth Israel Deaconess Medical Center/Har

Updated on:April 20,2024