An infamous 'inflammasome'—a rogue protein complex—appears to underlie a rare and disabling autoimmune disorder

by Delthia Ricks , Medical XpressCa2+ influx is required for PIEZO-dependent NLRP3 inflammasome activation. Credit:Science Immunology(2023). DOI: 10.1126/sciimmunol.adf4699Autoimmune disea

Updated on: March 30,2024 8

An infamous 'inflammasome'—a rogue protein complex—appears to underlie a rare and disabling autoimmune disorder

by Delthia Ricks , Medical XpressCa2+ influx is required for PIEZO-dependent NLRP3 inflammasome activation. Credit:Science Immunology(2023). DOI: 10.1126/sciimmunol.adf4699Autoimmune disea

Updated on:March 30,2024 8

A turncoat protein allows viruses to ride roughshod in the liver, paving the way to cancer

by Delthia Ricks , Medical XpressImages showing the distribution of tagged STING and HA-HPN proteins in liver cells. Credit: F. Hsin et al.,Science Signaling(2021)Chronic viral infections

Updated on: April 24,2024 19

A turncoat protein allows viruses to ride roughshod in the liver, paving the way to cancer

by Delthia Ricks , Medical XpressImages showing the distribution of tagged STING and HA-HPN proteins in liver cells. Credit: F. Hsin et al.,Science Signaling(2021)Chronic viral infections

Updated on:April 24,2024 19

Developing new classification criteria for improving antiphospholipid syndrome research

by Hospital for Special SurgeryCredit: CC0 Public DomainAn international team of more than 80 collaborators led by Hospital for Special Surgery (HSS) investigators is developing new classificatio

Updated on: March 26,2024 13

Developing new classification criteria for improving antiphospholipid syndrome research

by Hospital for Special SurgeryCredit: CC0 Public DomainAn international team of more than 80 collaborators led by Hospital for Special Surgery (HSS) investigators is developing new classificatio

Updated on:March 26,2024 13

Study sheds light on pregnancy complications and overturns common belief

by Hospital for Special Surgery"Many doctors may be unnecessarily treating some pregnant women who have antiphospholipid antibodies (aPLs) with anticoagulants, such as expensive heparin inje

Updated on: April 17,2024 14

Study sheds light on pregnancy complications and overturns common belief

by Hospital for Special Surgery"Many doctors may be unnecessarily treating some pregnant women who have antiphospholipid antibodies (aPLs) with anticoagulants, such as expensive heparin inje

Updated on:April 17,2024 14

Digitally reported patient outcomes tied to better disease control in rheumatoid arthritis

by Lori SolomonThe use of a digital health application with patient-reported outcomes is associated with an increase in disease control rate for adults with rheumatoid arthritis (RA), according to a s

Updated on: May 29,2024 4

Digitally reported patient outcomes tied to better disease control in rheumatoid arthritis

by Lori SolomonThe use of a digital health application with patient-reported outcomes is associated with an increase in disease control rate for adults with rheumatoid arthritis (RA), according to a s

Updated on:May 29,2024 4

Evolutionary study links subtle modifications in the morphology of the bipedal knee to osteoarthritis later in life

by Harvard UniversityA visual riff on the classic illustration, "March of Progress," highlighting the evolution of knee osteoarthritis. Credit: Tasha McAbee, Department of Orthopedics a

Updated on: May 08,2024 8

Evolutionary study links subtle modifications in the morphology of the bipedal knee to osteoarthritis later in life

by Harvard UniversityA visual riff on the classic illustration, "March of Progress," highlighting the evolution of knee osteoarthritis. Credit: Tasha McAbee, Department of Orthopedics a

Updated on:May 08,2024 8

Sex-specific immune response in COVID-19 linked to cellular metabolism

by Rick Harrison,Yale UniversityImage of the ultrastructural morphology exhibited by the 2019 Novel Coronavirus (2019-nCoV). Credit: CDCResearchers studying COVID-19 patients have found a metabo

Updated on: April 13,2024 12

Sex-specific immune response in COVID-19 linked to cellular metabolism

by Rick Harrison,Yale UniversityImage of the ultrastructural morphology exhibited by the 2019 Novel Coronavirus (2019-nCoV). Credit: CDCResearchers studying COVID-19 patients have found a metabo

Updated on:April 13,2024 12

Study examines care received by patients with knee osteoarthritis

by WileyCredit: CC0 Public DomainNew research reveals that only a minority of U.S. Medicare beneficiaries with knee osteoarthritis in 2005-2010 used non-surgical care such as physical therapy and

Updated on: May 19,2024 5

Study examines care received by patients with knee osteoarthritis

by WileyCredit: CC0 Public DomainNew research reveals that only a minority of U.S. Medicare beneficiaries with knee osteoarthritis in 2005-2010 used non-surgical care such as physical therapy and

Updated on:May 19,2024 5

An experimental vaccine against rheumatoid arthritis

by University of ToledoCredit: CC0 Public DomainResearchers at The University of Toledo have developed an experimental vaccine that shows significant promise in preventing rheumatoid arthritis, a

Updated on: June 28,2024 8

An experimental vaccine against rheumatoid arthritis

by University of ToledoCredit: CC0 Public DomainResearchers at The University of Toledo have developed an experimental vaccine that shows significant promise in preventing rheumatoid arthritis, a

Updated on:June 28,2024 8

Combined inhibition of TNF-alpha, IL-17 effective in RA model

(HealthDay)—Combined inhibition of tumor necrosis factor (TNF) α and interleukin (IL)-17 is more effective than single blockade in cultures of human fibroblast-like synoviocytes (FLS), according to an

Updated on: April 08,2024 11

Combined inhibition of TNF-alpha, IL-17 effective in RA model

(HealthDay)—Combined inhibition of tumor necrosis factor (TNF) α and interleukin (IL)-17 is more effective than single blockade in cultures of human fibroblast-like synoviocytes (FLS), according to an

Updated on:April 08,2024 11

Vascular disease in COVID-19 is not caused by viral infection of blood vessels

by University of QueenslandSARS-CoV-2 virus added to epithelial cells and infected cells shown in pink. Credit: University of QueenslandThe SARS-CoV-2 virus does not infect blood vessels, despite

Updated on: April 10,2024 15

Vascular disease in COVID-19 is not caused by viral infection of blood vessels

by University of QueenslandSARS-CoV-2 virus added to epithelial cells and infected cells shown in pink. Credit: University of QueenslandThe SARS-CoV-2 virus does not infect blood vessels, despite

Updated on:April 10,2024 15

CARv3-TEAM-E T-cell treatment beneficial for recurrent glioblastoma

by Elana GotkineFor patients with recurrent glioblastoma, treatment with chimeric antigen receptor (CAR) T-cells engineered to target the epidermal growth factor receptor (EGFR) variant III tumor-spec

Updated on: March 27,2024 0

CARv3-TEAM-E T-cell treatment beneficial for recurrent glioblastoma

by Elana GotkineFor patients with recurrent glioblastoma, treatment with chimeric antigen receptor (CAR) T-cells engineered to target the epidermal growth factor receptor (EGFR) variant III tumor-spec

Updated on:March 27,2024 0