New algorithm may greatly speed up the design of 'humanized' antibodies that work

by Weizmann Institute of Science3D structure of an antibody’s “finger,” the portion that binds to a target. The colored regions are responsible for recognizing the target; the gray regions provid

Updated on: March 07,2024

New algorithm may greatly speed up the design of 'humanized' antibodies that work

by Weizmann Institute of Science3D structure of an antibody’s “finger,” the portion that binds to a target. The colored regions are responsible for recognizing the target; the gray regions provid

Updated on:March 07,2024

Treatment options for patients whose blood cancer relapses after CAR-T cell therapy

by The Mount Sinai HospitalCredit: Pixabay/CC0 Public DomainMount Sinai and Memorial Sloan Kettering Cancer Center (MSK) researchers have identified therapies that can help patients with the bloo

Updated on: April 09,2024

Treatment options for patients whose blood cancer relapses after CAR-T cell therapy

by The Mount Sinai HospitalCredit: Pixabay/CC0 Public DomainMount Sinai and Memorial Sloan Kettering Cancer Center (MSK) researchers have identified therapies that can help patients with the bloo

Updated on:April 09,2024

How an emerging drug class dampens harmful immune reactions

by Angelika Jacobs,University of BaselOverview of complement mechanisms and compstatin-based inhibitor development.aSimplified scheme of the complement cascade with major effector fu

Updated on: March 25,2024

How an emerging drug class dampens harmful immune reactions

by Angelika Jacobs,University of BaselOverview of complement mechanisms and compstatin-based inhibitor development.aSimplified scheme of the complement cascade with major effector fu

Updated on:March 25,2024

Indoor allergens worsen respiratory infections in children with asthma, study finds

byUniversity of Texas at AustinCredit: Andrea Piacquadio from PexelsChildren with asthma who are exposed to high levels of indoor allergens, such as cockroach and mouse allergens, are at an incr

Updated on: September 18,2024

Indoor allergens worsen respiratory infections in children with asthma, study finds

byUniversity of Texas at AustinCredit: Andrea Piacquadio from PexelsChildren with asthma who are exposed to high levels of indoor allergens, such as cockroach and mouse allergens, are at an incr

Updated on:September 18,2024

STIM-mediated calcium influx regulates maintenance and selection of germinal center B cells: Study

by Osaka UniversityCredit:Journal of Experimental Medicine(2023). DOI: 10.1084/jem.20222178Germinal centers (GCs) are specialized microenvironments where antigen (Ag)-specific B cells

Updated on: April 22,2024

STIM-mediated calcium influx regulates maintenance and selection of germinal center B cells: Study

by Osaka UniversityCredit:Journal of Experimental Medicine(2023). DOI: 10.1084/jem.20222178Germinal centers (GCs) are specialized microenvironments where antigen (Ag)-specific B cells

Updated on:April 22,2024

Gut bacteria important for overcoming milk allergy, study suggests

by RIKENThe study found that successful oral immunotherapy in children was associated with having Bifidobacterium bacteria in the gut, while unsuccessful treatment was associated with having ecze

Updated on: March 20,2024

Gut bacteria important for overcoming milk allergy, study suggests

by RIKENThe study found that successful oral immunotherapy in children was associated with having Bifidobacterium bacteria in the gut, while unsuccessful treatment was associated with having ecze

Updated on:March 20,2024

Repurposing tocilizumab in scleroderma patients may prevent early lung disease

by Jordyn Imhoff,University of MichiganCredit: CC0 Public DomainResearch led by Michigan Medicine's Scleroderma Program and published in Arthritis & Rheumatology found that tocilizumab,

Updated on: April 07,2024

Repurposing tocilizumab in scleroderma patients may prevent early lung disease

by Jordyn Imhoff,University of MichiganCredit: CC0 Public DomainResearch led by Michigan Medicine's Scleroderma Program and published in Arthritis & Rheumatology found that tocilizumab,

Updated on:April 07,2024

High body temperature increases resistance to pathogenic viral infections, new study finds

by University of Tokyo"Influenza Virus" by NIAID. Credit: Minami Nagai, Miyu Moriyama, Chiharu Ishii, Hirotake Mori, Hikaru Watanabe, Taku Nakahara, Takuji Yamada, Dai Ishikawa, Takamas

Updated on: May 06,2024

High body temperature increases resistance to pathogenic viral infections, new study finds

by University of Tokyo"Influenza Virus" by NIAID. Credit: Minami Nagai, Miyu Moriyama, Chiharu Ishii, Hirotake Mori, Hikaru Watanabe, Taku Nakahara, Takuji Yamada, Dai Ishikawa, Takamas

Updated on:May 06,2024

Preventing cell death as novel therapeutic strategy for rheumatoid arthritis

by VIB (the Flanders Institute for Biotechnology)Credit: CC0 Public DomainA collaborative study has identified a new molecular mechanism causing rheumatoid arthritis. The researchers found that d

Updated on: March 30,2024

Preventing cell death as novel therapeutic strategy for rheumatoid arthritis

by VIB (the Flanders Institute for Biotechnology)Credit: CC0 Public DomainA collaborative study has identified a new molecular mechanism causing rheumatoid arthritis. The researchers found that d

Updated on:March 30,2024

Combination of LABA + inhaled glucocorticoid safe in asthma

(HealthDay)—Compared to treatment with an inhaled glucocorticoid alone, combination therapy with a long-acting β2-agonist (LABA) and an inhaled glucocorticoid is not associated with a significantly hi

Updated on: April 16,2024

Combination of LABA + inhaled glucocorticoid safe in asthma

(HealthDay)—Compared to treatment with an inhaled glucocorticoid alone, combination therapy with a long-acting β2-agonist (LABA) and an inhaled glucocorticoid is not associated with a significantly hi

Updated on:April 16,2024

Risk of severe breakthrough COVID-19 infection is higher for people with HIV with moderately low CD4 cell counts

by Johns Hopkins University Bloomberg School of Public HealthGraphs show incidence of severe COVID-19 breakthrough illness by HIV status (A) (log-rank test P = .40), by CD4 cell count and HIV sta

Updated on: April 09,2024

Risk of severe breakthrough COVID-19 infection is higher for people with HIV with moderately low CD4 cell counts

by Johns Hopkins University Bloomberg School of Public HealthGraphs show incidence of severe COVID-19 breakthrough illness by HIV status (A) (log-rank test P = .40), by CD4 cell count and HIV sta

Updated on:April 09,2024

A plant-based compound that inhibits reactivation of the HIV viral reservoir, giving the immune system a break

by The Wistar InstituteOverview of HIV inhibitor screening strategy and identification of (–)-hopeaphenol. (A) Representative flow cytometry examples of HIV-GFP reporter expression in unstimulate

Updated on: May 05,2024

A plant-based compound that inhibits reactivation of the HIV viral reservoir, giving the immune system a break

by The Wistar InstituteOverview of HIV inhibitor screening strategy and identification of (–)-hopeaphenol. (A) Representative flow cytometry examples of HIV-GFP reporter expression in unstimulate

Updated on:May 05,2024