Mettl3-dependent m6A modification is essential for effector differentiation and memory formation of CD8+ T cells

byScience China PressDuring viral infection, total m6A levels in Naïve stage, effector stage, and memory stage exhibit dynamic alteration (high-low-high). The presence of Mettl3 promotes CD8 T c

Updated on: January 26,2024 19

Mettl3-dependent m6A modification is essential for effector differentiation and memory formation of CD8+ T cells

byScience China PressDuring viral infection, total m6A levels in Naïve stage, effector stage, and memory stage exhibit dynamic alteration (high-low-high). The presence of Mettl3 promotes CD8 T c

Updated on:January 26,2024 19

The 'switch' that keeps the immune system from attacking the body

by Ecole Polytechnique Federale de LausanneCredit: CC0 Public DomainA microscopic battle rages in our bodies, as our cells constantly fend off invaders through our immune system: a complex system

Updated on: March 07,2024 20

The 'switch' that keeps the immune system from attacking the body

by Ecole Polytechnique Federale de LausanneCredit: CC0 Public DomainA microscopic battle rages in our bodies, as our cells constantly fend off invaders through our immune system: a complex system

Updated on:March 07,2024 20

St18 is a negative regulator of VEGF

by National Institutes of Natural SciencesSt18 inhibits VEGF expression via Sp1 suppression. Credit: Kenta MaruyamaPro-inflammatory cytokines and pathogen-associated molecular patterns such as lipopol

Updated on: April 22,2024 15

St18 is a negative regulator of VEGF

by National Institutes of Natural SciencesSt18 inhibits VEGF expression via Sp1 suppression. Credit: Kenta MaruyamaPro-inflammatory cytokines and pathogen-associated molecular patterns such as lipopol

Updated on:April 22,2024 15

Immune system's moonlighters point the way to a new therapeutic target

FEBRUARY 20, 2024byCold Spring Harbor LaboratoryGraphical abstract. Credit:Molecular Cell(2024). DOI: 10.1016/j.molcel.2024.01.007Our immune system is remarkably powerful. It quickly

Updated on: March 25,2024 5

Immune system's moonlighters point the way to a new therapeutic target

FEBRUARY 20, 2024byCold Spring Harbor LaboratoryGraphical abstract. Credit:Molecular Cell(2024). DOI: 10.1016/j.molcel.2024.01.007Our immune system is remarkably powerful. It quickly

Updated on:March 25,2024 5

Bacteria in the intestine that change in response to inflammation could have an impact on our immune system

by Technion - Israel Institute of TechnologyGraphical abstract . Credit: Cell Host & Microbe (2024). DOI: 10.1016/j.chom.2024.02.003Gut bacteria have emerged as a focal point of scientific explora

Updated on: May 14,2024 0

Bacteria in the intestine that change in response to inflammation could have an impact on our immune system

by Technion - Israel Institute of TechnologyGraphical abstract . Credit: Cell Host & Microbe (2024). DOI: 10.1016/j.chom.2024.02.003Gut bacteria have emerged as a focal point of scientific explora

Updated on:May 14,2024 0

Key steps could reduces cases and deaths from rheumatic heart disease in the African Union

by Brigham and Women's HospitalCredit: Unsplash/CC0 Public DomainRheumatic heart disease (RHD) remains a major cause of cardiovascular disease in Africa, even as acute rheumatic fever and RHD

Updated on: June 01,2024 7

Key steps could reduces cases and deaths from rheumatic heart disease in the African Union

by Brigham and Women's HospitalCredit: Unsplash/CC0 Public DomainRheumatic heart disease (RHD) remains a major cause of cardiovascular disease in Africa, even as acute rheumatic fever and RHD

Updated on:June 01,2024 7

The role of T cells in fighting cancer

by CU Anschutz Medical CampusCredit: CC0 Public DomainNew research from CU Cancer Center member Jing Hong Wang, MD, Ph.D., and recent University of Colorado Immunology program graduate Rachel Woo

Updated on: April 24,2024 18

The role of T cells in fighting cancer

by CU Anschutz Medical CampusCredit: CC0 Public DomainNew research from CU Cancer Center member Jing Hong Wang, MD, Ph.D., and recent University of Colorado Immunology program graduate Rachel Woo

Updated on:April 24,2024 18

Researchers reveal molecular mechanism of cytokine storm induced by coronavirus

by Zhang Nannan,Chinese Academy of SciencesSARS-CoV-2 stabilizes host mRNAs to induce cytokine storm. Credit: Xue Yuanchao's groupIn the past four years, the pathogen responsible for Coronav

Updated on: January 26,2024 21

Researchers reveal molecular mechanism of cytokine storm induced by coronavirus

by Zhang Nannan,Chinese Academy of SciencesSARS-CoV-2 stabilizes host mRNAs to induce cytokine storm. Credit: Xue Yuanchao's groupIn the past four years, the pathogen responsible for Coronav

Updated on:January 26,2024 21

Epigenetics is of critical importance in autoimmune-related skin diseases, says study

by Higher Education PressCredit: Lingyu Gao, Qianjin LuThe central dogma proposed that genetic information predominantly transfers from DNA to RNA during gene expression to make a functional product p

Updated on: March 27,2024 0

Epigenetics is of critical importance in autoimmune-related skin diseases, says study

by Higher Education PressCredit: Lingyu Gao, Qianjin LuThe central dogma proposed that genetic information predominantly transfers from DNA to RNA during gene expression to make a functional product p

Updated on:March 27,2024 0

Researchers validate pediatric 'allergic march' in largest national study of its kind

byChildren's Hospital of PhiladelphiaCredit: Unsplash/CC0 Public DomainIn the largest study of its kind, researchers from Children's Hospital of Philadelphia (CHOP) used electronic healt

Updated on: March 05,2024 2

Researchers validate pediatric 'allergic march' in largest national study of its kind

byChildren's Hospital of PhiladelphiaCredit: Unsplash/CC0 Public DomainIn the largest study of its kind, researchers from Children's Hospital of Philadelphia (CHOP) used electronic healt

Updated on:March 05,2024 2

Trial compares therapies for reducing cardiovascular risk among people with rheumatoid arthritis

by Brigham and Women's HospitalCredit: Unsplash/CC0 Public DomainPeople with rheumatoid arthritis are at increased risk of cardiovascular (CV) disease, with studies indicating an approximate

Updated on: May 13,2024 5

Trial compares therapies for reducing cardiovascular risk among people with rheumatoid arthritis

by Brigham and Women's HospitalCredit: Unsplash/CC0 Public DomainPeople with rheumatoid arthritis are at increased risk of cardiovascular (CV) disease, with studies indicating an approximate

Updated on:May 13,2024 5

Study finds opioids double risk of venous thromboembolism in rheumatoid arthritis patients

by American College of RheumatologyRisk of outcomes (HR, 95% CI) with opioid initiation compared to NSAID initiation after adjustment for propensity score weights and imbalanced covariables (CVD

Updated on: May 13,2024 5

Study finds opioids double risk of venous thromboembolism in rheumatoid arthritis patients

by American College of RheumatologyRisk of outcomes (HR, 95% CI) with opioid initiation compared to NSAID initiation after adjustment for propensity score weights and imbalanced covariables (CVD

Updated on:May 13,2024 5