Study shows genetically modified pluripotent stem cells may evade immunological rejection after transplantation

by University of ArizonaGeneration of an HLA-I/II and MICA/B-deficient hESC line (A) Representation of the Cas9 editing strategy. Wild-type H1 hESCs were transfected with a Cas9 construct and up

Updated on: March 07,2024 18

Study shows genetically modified pluripotent stem cells may evade immunological rejection after transplantation

by University of ArizonaGeneration of an HLA-I/II and MICA/B-deficient hESC line (A) Representation of the Cas9 editing strategy. Wild-type H1 hESCs were transfected with a Cas9 construct and up

Updated on:March 07,2024 18

Knee arthritis: Steroid shots may not help long-term, ozone injections promising

Two studies test out old and new treatments for the debilitating ailment.(HealthDay)—Millions of aging Americans are plagued by arthritic knees, and two new studies offer insight into what might—or mi

Updated on: April 08,2024 15

Knee arthritis: Steroid shots may not help long-term, ozone injections promising

Two studies test out old and new treatments for the debilitating ailment.(HealthDay)—Millions of aging Americans are plagued by arthritic knees, and two new studies offer insight into what might—or mi

Updated on:April 08,2024 15

Certain criteria may be better than others in RA assessment

(HealthDay)—For patients with rheumatoid arthritis (RA), the performances of the Clinical Disease Activity Index (CDAI) and Simplified Disease Activity Index (SDAI) appear to be better than that of th

Updated on: March 30,2024 13

Certain criteria may be better than others in RA assessment

(HealthDay)—For patients with rheumatoid arthritis (RA), the performances of the Clinical Disease Activity Index (CDAI) and Simplified Disease Activity Index (SDAI) appear to be better than that of th

Updated on:March 30,2024 13

A gene that plays a critical role in natural killer cell differentiation

by Bob Yirka , Medical XpressAn illustration of natural killer cells. Credit: Val Altounian / AAASA large team of researchers affiliated with a host of institutions in Europe and the U.S. has found a

Updated on: March 25,2024 17

A gene that plays a critical role in natural killer cell differentiation

by Bob Yirka , Medical XpressAn illustration of natural killer cells. Credit: Val Altounian / AAASA large team of researchers affiliated with a host of institutions in Europe and the U.S. has found a

Updated on:March 25,2024 17

Moms with lupus more likely to have children with autism, study suggests

by Serena Gordon, Healthday ReporterBut overall risk is low, shouldn't influence parenting decisions, expert says.(HealthDay)—Women with lupus are twice as likely to have a child with autism compa

Updated on: March 24,2024 13

Moms with lupus more likely to have children with autism, study suggests

by Serena Gordon, Healthday ReporterBut overall risk is low, shouldn't influence parenting decisions, expert says.(HealthDay)—Women with lupus are twice as likely to have a child with autism compa

Updated on:March 24,2024 13

Switching to vegan or ketogenic diet rapidly impacts immune system, study shows

by NIH/National Institute of Allergy and Infectious DiseasesSchematic of experimental setup. Twenty participants were split into two groups (first group: 4 females (pink), 6 males (blue); second

Updated on: March 07,2024 12

Switching to vegan or ketogenic diet rapidly impacts immune system, study shows

by NIH/National Institute of Allergy and Infectious DiseasesSchematic of experimental setup. Twenty participants were split into two groups (first group: 4 females (pink), 6 males (blue); second

Updated on:March 07,2024 12

An AI strategy for identifying new immunotherapy targets

by Cleveland ClinicSlowest relaxation timescales estimated by unsupervised AI highlight concerted MHC–peptide dynamics and multiple peptide presentation modes. Credit:Briefings in Bioinform

Updated on: March 07,2024 19

An AI strategy for identifying new immunotherapy targets

by Cleveland ClinicSlowest relaxation timescales estimated by unsupervised AI highlight concerted MHC–peptide dynamics and multiple peptide presentation modes. Credit:Briefings in Bioinform

Updated on:March 07,2024 19

Primary care provider training program improves rheumatoid arthritis care in Navajo Nation

by American College of RheumatologyMean (SD) pre-training, mean (SD) post-training, and marginal (95% CI) change in performance on RA knowledge test [N=9]. Credit: The Rheumatology Access Expansi

Updated on: May 13,2024 3

Primary care provider training program improves rheumatoid arthritis care in Navajo Nation

by American College of RheumatologyMean (SD) pre-training, mean (SD) post-training, and marginal (95% CI) change in performance on RA knowledge test [N=9]. Credit: The Rheumatology Access Expansi

Updated on:May 13,2024 3

Study advances understanding of liver immune response in cirrhosis

byMiguel Hernandez University of ElcheLSECtin expression in the liver inversely correlates with Th17 expansion in cirrhosis. (A) Representative Immunohistochemistry of the lymphocyte-specific tr

Updated on: April 28,2024 0

Study advances understanding of liver immune response in cirrhosis

byMiguel Hernandez University of ElcheLSECtin expression in the liver inversely correlates with Th17 expansion in cirrhosis. (A) Representative Immunohistochemistry of the lymphocyte-specific tr

Updated on:April 28,2024 0

Developing new classification criteria for improving antiphospholipid syndrome research

by Hospital for Special SurgeryCredit: CC0 Public DomainAn international team of more than 80 collaborators led by Hospital for Special Surgery (HSS) investigators is developing new classificatio

Updated on: March 26,2024 13

Developing new classification criteria for improving antiphospholipid syndrome research

by Hospital for Special SurgeryCredit: CC0 Public DomainAn international team of more than 80 collaborators led by Hospital for Special Surgery (HSS) investigators is developing new classificatio

Updated on:March 26,2024 13

Combined inhibition of TNF-alpha, IL-17 effective in RA model

(HealthDay)—Combined inhibition of tumor necrosis factor (TNF) α and interleukin (IL)-17 is more effective than single blockade in cultures of human fibroblast-like synoviocytes (FLS), according to an

Updated on: April 08,2024 11

Combined inhibition of TNF-alpha, IL-17 effective in RA model

(HealthDay)—Combined inhibition of tumor necrosis factor (TNF) α and interleukin (IL)-17 is more effective than single blockade in cultures of human fibroblast-like synoviocytes (FLS), according to an

Updated on:April 08,2024 11

STIM-mediated calcium influx regulates maintenance and selection of germinal center B cells: Study

by Osaka UniversityCredit:Journal of Experimental Medicine(2023). DOI: 10.1084/jem.20222178Germinal centers (GCs) are specialized microenvironments where antigen (Ag)-specific B cells

Updated on: April 22,2024 13

STIM-mediated calcium influx regulates maintenance and selection of germinal center B cells: Study

by Osaka UniversityCredit:Journal of Experimental Medicine(2023). DOI: 10.1084/jem.20222178Germinal centers (GCs) are specialized microenvironments where antigen (Ag)-specific B cells

Updated on:April 22,2024 13