TAp63: A new protein drug target for rheumatoid arthritis

by Chiba UniversityGraphical abstract. Credit:JCI Insight(2023). DOI: 10.1172/jci.insight.164778Rheumatoid arthritis (RA) is an autoimmune disease characterized by joint deterioration. The

Updated on: May 08,2024

TAp63: A new protein drug target for rheumatoid arthritis

by Chiba UniversityGraphical abstract. Credit:JCI Insight(2023). DOI: 10.1172/jci.insight.164778Rheumatoid arthritis (RA) is an autoimmune disease characterized by joint deterioration. The

Updated on:May 08,2024

COVID-19: Biomarkers linked to severe forms of the disease

by University of MontrealColorized scanning electron micrograph of an apoptotic cell (green) heavily infected with SARS-COV-2 virus particles (yellow), isolated from a patient sample. Image captu

Updated on: April 13,2024

COVID-19: Biomarkers linked to severe forms of the disease

by University of MontrealColorized scanning electron micrograph of an apoptotic cell (green) heavily infected with SARS-COV-2 virus particles (yellow), isolated from a patient sample. Image captu

Updated on:April 13,2024

Brain activity linked to TNF inhibitor response in RA

Patients with rheumatoid arthritis who respond to tumor necrosis factor inhibitors show changes in activity in pain-related areas of the brain before clinical signs of improvement are observed, accord

Updated on: April 08,2024

Brain activity linked to TNF inhibitor response in RA

Patients with rheumatoid arthritis who respond to tumor necrosis factor inhibitors show changes in activity in pain-related areas of the brain before clinical signs of improvement are observed, accord

Updated on:April 08,2024

A better test for the tumor-targeting of CAR-T therapies

by Ludwig Institute for Cancer ResearchCredit: CC0 Public DomainLudwig Cancer Research scientists have developed a method to significantly improve the preclinical evaluation of chimeric antigen-r

Updated on: April 24,2024

A better test for the tumor-targeting of CAR-T therapies

by Ludwig Institute for Cancer ResearchCredit: CC0 Public DomainLudwig Cancer Research scientists have developed a method to significantly improve the preclinical evaluation of chimeric antigen-r

Updated on:April 24,2024

The case of the missing monocyte: Scientists investigate gene that appears to protect against rheumatoid arthritis

by University of North Carolina at Chapel Hill School of MedicineThe hands of a person with arthritis. Image source: NIH.(Medical Xpress) -- An estimated 1.3 million people in the United States s

Updated on: March 24,2024

The case of the missing monocyte: Scientists investigate gene that appears to protect against rheumatoid arthritis

by University of North Carolina at Chapel Hill School of MedicineThe hands of a person with arthritis. Image source: NIH.(Medical Xpress) -- An estimated 1.3 million people in the United States s

Updated on:March 24,2024

Scientists discover how to improve vaccine response to potentially deadly bacterium

byTrinity College DublinScanning electromicrograph of Staphylococcus aureus bacteria. Credit: NIAIDResearchers from Trinity College Dublin have taken a leap forward in understanding how we might

Updated on: July 09,2024

Scientists discover how to improve vaccine response to potentially deadly bacterium

byTrinity College DublinScanning electromicrograph of Staphylococcus aureus bacteria. Credit: NIAIDResearchers from Trinity College Dublin have taken a leap forward in understanding how we might

Updated on:July 09,2024

Researchers identify new arthritis severity gene

by The Mount Sinai HospitalCredit: CC0 Public DomainA new gene associated with disease severity in models of rheumatoid arthritis has been identified by researchers at the Icahn School of Medicin

Updated on: June 06,2024

Researchers identify new arthritis severity gene

by The Mount Sinai HospitalCredit: CC0 Public DomainA new gene associated with disease severity in models of rheumatoid arthritis has been identified by researchers at the Icahn School of Medicin

Updated on:June 06,2024

Higher incidence of edema with bacteriuria in C1-INH-HAE

(HealthDay)—For patients with hereditary angioedema due to C1-inhibitor deficiency (C1-INH-HAE), those with bacteriuria have a higher number of edematous attacks, according to a study published online

Updated on: April 08,2024

Higher incidence of edema with bacteriuria in C1-INH-HAE

(HealthDay)—For patients with hereditary angioedema due to C1-inhibitor deficiency (C1-INH-HAE), those with bacteriuria have a higher number of edematous attacks, according to a study published online

Updated on:April 08,2024

Does physical activity impact risk of knee osteoarthritis?

by WileyCredit: CC0 Public DomainIn an analysis published inArthritis & Rheumatology, investigators did not find any link between the amount and duration of physical activity with indiv

Updated on: April 17,2024

Does physical activity impact risk of knee osteoarthritis?

by WileyCredit: CC0 Public DomainIn an analysis published inArthritis & Rheumatology, investigators did not find any link between the amount and duration of physical activity with indiv

Updated on:April 17,2024

Scientists create first mouse model with complete, functional human immune system

byUniversity of Texas Health Science Center at San AntonioLeft, malar rash in a (huNSGW41-derived) Lupus THX mouse (three weeks after pristane injection). Middle, serum antinuclear IgGs (scale b

Updated on: July 09,2024

Scientists create first mouse model with complete, functional human immune system

byUniversity of Texas Health Science Center at San AntonioLeft, malar rash in a (huNSGW41-derived) Lupus THX mouse (three weeks after pristane injection). Middle, serum antinuclear IgGs (scale b

Updated on:July 09,2024

Examining inflammatory bowel disease after a stem cell transplant

byUniversity of BaselColon sections of the index patient in active IBDvs. clinical remission (under infliximab therapy) were stained by immune histology for CD5 (a pan T cell marker) and f

Updated on: March 27,2024

Examining inflammatory bowel disease after a stem cell transplant

byUniversity of BaselColon sections of the index patient in active IBDvs. clinical remission (under infliximab therapy) were stained by immune histology for CD5 (a pan T cell marker) and f

Updated on:March 27,2024

Mast cell levels may explain sex differences in osteoarthritis pain

by Hospital for Special SurgeryCredit: Pixabay/CC0 Public DomainInvestigators at Hospital for Special Surgery (HSS) have discovered that at the time of total knee replacement, women have signific

Updated on: April 17,2024

Mast cell levels may explain sex differences in osteoarthritis pain

by Hospital for Special SurgeryCredit: Pixabay/CC0 Public DomainInvestigators at Hospital for Special Surgery (HSS) have discovered that at the time of total knee replacement, women have signific

Updated on:April 17,2024