Circuit-specific gene therapy brings new hope for treatment of Parkinson's disease

byChinese Academy of SciencesRetrograde AAV selectively targets D1-MSNs and rescues parkinsonian symptoms with chemogenetic modulation. Credit: SIATResearchers from the Shenzhen Institute of Adv

Updated on: March 14,2024 16

Circuit-specific gene therapy brings new hope for treatment of Parkinson's disease

byChinese Academy of SciencesRetrograde AAV selectively targets D1-MSNs and rescues parkinsonian symptoms with chemogenetic modulation. Credit: SIATResearchers from the Shenzhen Institute of Adv

Updated on:March 14,2024 16

Study eases concern at antipsychotics use in pregnancy

byUniversity of New South WalesCrude and propensity score-weighted cumulative incidence (with 95% confidence intervals) for composite neurodevelopmental outcome from age 3–19 years in children o

Updated on: March 28,2024 0

Study eases concern at antipsychotics use in pregnancy

byUniversity of New South WalesCrude and propensity score-weighted cumulative incidence (with 95% confidence intervals) for composite neurodevelopmental outcome from age 3–19 years in children o

Updated on:March 28,2024 0

First clinical trial of vosoritide for children with hypochondroplasia shows increased growth

byChildren's National HospitalStanding height SDS. Credit:eClinicalMedicine(2024). DOI: 10.1016/j.eclinm.2024.102591Vosoritide's first global Phase II study showed an average

Updated on: April 28,2024 0

First clinical trial of vosoritide for children with hypochondroplasia shows increased growth

byChildren's National HospitalStanding height SDS. Credit:eClinicalMedicine(2024). DOI: 10.1016/j.eclinm.2024.102591Vosoritide's first global Phase II study showed an average

Updated on:April 28,2024 0

Trials shows bimekizumab response durable at four years for moderate-to-severe psoriasis

by Tina BrownPatients with psoriasis treated with bimekizumab rapidly achieve high levels of clinical and health-related quality-of-life responses that are durable at four years, according to research

Updated on: March 28,2024 0

Trials shows bimekizumab response durable at four years for moderate-to-severe psoriasis

by Tina BrownPatients with psoriasis treated with bimekizumab rapidly achieve high levels of clinical and health-related quality-of-life responses that are durable at four years, according to research

Updated on:March 28,2024 0

Better cancer trials could be around the corner

by Cold Spring Harbor LaboratoryCredit: Pixabay/CC0 Public DomainCold Spring Harbor Laboratory Associate Professor and Cancer Center member Tobias Janowitz led aCOVID-19 clinical trial&nbsp

Updated on: March 30,2024 18

Better cancer trials could be around the corner

by Cold Spring Harbor LaboratoryCredit: Pixabay/CC0 Public DomainCold Spring Harbor Laboratory Associate Professor and Cancer Center member Tobias Janowitz led aCOVID-19 clinical trial&nbsp

Updated on:March 30,2024 18

World-first human trial finds arthritis drug can suppress progression of type 1 diabetes

DECEMBER 6, 2023bySt Vincent's Institute of Medical ResearchCredit: CC0 Public DomainResearchers at St Vincent's Institute of Medical Research (SVI) in Melbourne have shown that a common

Updated on: March 25,2024 4

World-first human trial finds arthritis drug can suppress progression of type 1 diabetes

DECEMBER 6, 2023bySt Vincent's Institute of Medical ResearchCredit: CC0 Public DomainResearchers at St Vincent's Institute of Medical Research (SVI) in Melbourne have shown that a common

Updated on:March 25,2024 4

Exercise and Liraglutide: Effects on Weight Loss and Bone Health

This article delves into a study that investigates the effects of exercise, liraglutide, and their combination on weight loss and bone mineral density (BMD) in individuals with obesity.

Updated on: July 24,2024 0

Exercise and Liraglutide: Effects on Weight Loss and Bone Health

This article delves into a study that investigates the effects of exercise, liraglutide, and their combination on weight loss and bone mineral density (BMD) in individuals with obesity.

Updated on:July 24,2024 0

Research provides further evidence that epigenetic changes can cause type 2 diabetes

byLund UniversityStudy design. EPIC array DNA methylation in islets of 25 T2D cases and 75 controls. RNA-seq data were available for 25 T2D cases and 72 controls. Islet DNA methylation was assoc

Updated on: March 13,2024 5

Research provides further evidence that epigenetic changes can cause type 2 diabetes

byLund UniversityStudy design. EPIC array DNA methylation in islets of 25 T2D cases and 75 controls. RNA-seq data were available for 25 T2D cases and 72 controls. Islet DNA methylation was assoc

Updated on:March 13,2024 5

Working conditions can explain educational differences in heart disease mortality

byKarolinska InstitutetCredit: Pixabay/CC0 Public DomainResearchers from the Institute of Environmental Medicine at Karolinska Institutet have found that low influence and opportunities for deve

Updated on: April 28,2024 0

Working conditions can explain educational differences in heart disease mortality

byKarolinska InstitutetCredit: Pixabay/CC0 Public DomainResearchers from the Institute of Environmental Medicine at Karolinska Institutet have found that low influence and opportunities for deve

Updated on:April 28,2024 0

How to make mRNA therapeutics safe from the start

FEBRUARY 28, 2024by Cynthia McCormick Hibbert,Northeastern UniversityScientists eager to harness mRNA technology to fight cancer and more need to find ways to test early for safety, Northeastern

Updated on: March 25,2024 6

How to make mRNA therapeutics safe from the start

FEBRUARY 28, 2024by Cynthia McCormick Hibbert,Northeastern UniversityScientists eager to harness mRNA technology to fight cancer and more need to find ways to test early for safety, Northeastern

Updated on:March 25,2024 6

Making clinical guidelines work for large language models

by Rachel Martin,Yale UniversityExample of a clinical decision support system integrated with large language models. Credit:npj Digital Medicine(2024). DOI: 10.1038/s41746-024-01091-

Updated on: July 23,2024 0

Making clinical guidelines work for large language models

by Rachel Martin,Yale UniversityExample of a clinical decision support system integrated with large language models. Credit:npj Digital Medicine(2024). DOI: 10.1038/s41746-024-01091-

Updated on:July 23,2024 0

New compound shows early promise for treatment of Lou Gehrig's disease in preclinical models

NOVEMBER 7, 2023by Jaclyn Dunne,Medical University of South CarolinaMitochondrial membrane rearrangements are critical in recruiting p17/PERMIT-CerS1 to mitochondria. Credit:Aging Cell&nbs

Updated on: March 25,2024 6

New compound shows early promise for treatment of Lou Gehrig's disease in preclinical models

NOVEMBER 7, 2023by Jaclyn Dunne,Medical University of South CarolinaMitochondrial membrane rearrangements are critical in recruiting p17/PERMIT-CerS1 to mitochondria. Credit:Aging Cell&nbs

Updated on:March 25,2024 6