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Difficulties of setting efficacy endpoints in early-stage clinical trials of brain tumor drugs

Difficulties of setting efficacy endpoints in early-stage clinical trials of brain tumor drugs

byUniversity of TsukubaCredit: Anna Shvets from PexelsClinical trials for cancer drugs have three stages, Phase I–III, before marketing, each with different evaluation items. However, there is n

Difficulties of setting efficacy endpoints in early-stage clinical trials of brain tumor drugs

byUniversity of TsukubaCredit: Anna Shvets from PexelsClinical trials for cancer drugs have three stages, Phase I–III, before marketing, each with different evaluation items. However, there is n
Researchers identify potential way to treat genetic epilepsy by replacing 'lost' enzyme

Researchers identify potential way to treat genetic epilepsy by replacing 'lost' enzyme

byThe Francis Crick InstituteCredit: Pixabay/CC0 Public DomainScientists at the Francis Crick Institute have found a new treatment target for CDKL5 deficiency disorder (CDD), one of the most com

Researchers identify potential way to treat genetic epilepsy by replacing 'lost' enzyme

byThe Francis Crick InstituteCredit: Pixabay/CC0 Public DomainScientists at the Francis Crick Institute have found a new treatment target for CDKL5 deficiency disorder (CDD), one of the most com
Study shows tendency for infection and bacterial flora explain caries

Study shows tendency for infection and bacterial flora explain caries

byUmea UniversityCredit:eBioMedicine(2024). DOI: 10.1016/j.ebiom.2024.105001Researchers at Umeå University have for the first time been able to show that individual variation in susc

Study shows tendency for infection and bacterial flora explain caries

byUmea UniversityCredit:eBioMedicine(2024). DOI: 10.1016/j.ebiom.2024.105001Researchers at Umeå University have for the first time been able to show that individual variation in susc
Researchers discover a new role for a protein that helps form memories

Researchers discover a new role for a protein that helps form memories

by Marya Barlow,Virginia Tech(From left) Research scientist Kayla Farrell and Associate Professor Tim Jarome in the School of Animal Sciences are part of a Virginia Tech research team that disco

Researchers discover a new role for a protein that helps form memories

by Marya Barlow,Virginia Tech(From left) Research scientist Kayla Farrell and Associate Professor Tim Jarome in the School of Animal Sciences are part of a Virginia Tech research team that disco
Different autism risk genes, same effects on brain development

Different autism risk genes, same effects on brain development

by Harvard UniversityMicroscopy image of a brain organoid showing neuron precursors (magenta) and deep-layer projection neurons (green), which are one of the cell types affected by autism risk ge

Different autism risk genes, same effects on brain development

by Harvard UniversityMicroscopy image of a brain organoid showing neuron precursors (magenta) and deep-layer projection neurons (green), which are one of the cell types affected by autism risk ge
Study shows how genes in retina are regulated during development

Study shows how genes in retina are regulated during development

byNational Institutes of HealthThis image metaphorically captures the cell differentiation process during retinal organoid development. Loose yarn representing uncompacted DNA is wound by a croc

Study shows how genes in retina are regulated during development

byNational Institutes of HealthThis image metaphorically captures the cell differentiation process during retinal organoid development. Loose yarn representing uncompacted DNA is wound by a croc
Altering key ion channel found to protect against pancreatitis-associated acute lung injury

Altering key ion channel found to protect against pancreatitis-associated acute lung injury

JANUARY 11, 2024byAmerican Physiological SocietyCredit:Function(2023). DOI: 10.1093/function/zqad061A group of Chinese researchers has conducted a mouse study to determine the role o

Altering key ion channel found to protect against pancreatitis-associated acute lung injury

JANUARY 11, 2024byAmerican Physiological SocietyCredit:Function(2023). DOI: 10.1093/function/zqad061A group of Chinese researchers has conducted a mouse study to determine the role o
Listen to your gut: Research discusses using microbiota analysis for precision health care

Listen to your gut: Research discusses using microbiota analysis for precision health care

by Sarah Small,Pennsylvania State UniversityIn a recently published paper, Pak Kin Wong discusses the methods discusses the methods available for incorporating microbiota analysis into clinical

Listen to your gut: Research discusses using microbiota analysis for precision health care

by Sarah Small,Pennsylvania State UniversityIn a recently published paper, Pak Kin Wong discusses the methods discusses the methods available for incorporating microbiota analysis into clinical
New insight into dying cells in Parkinson's disease

New insight into dying cells in Parkinson's disease

APRIL 25, 2023by Birgitte Svennevig, University of Southern DenmarkGraphical Abstract. Credit:Cell Reports(2023). DOI: 10.1016/j.celrep.2023.112180When a patient experiences the first symp

New insight into dying cells in Parkinson's disease

APRIL 25, 2023by Birgitte Svennevig, University of Southern DenmarkGraphical Abstract. Credit:Cell Reports(2023). DOI: 10.1016/j.celrep.2023.112180When a patient experiences the first symp
Wound-homing molecule found to accelerate tissue repair

Wound-homing molecule found to accelerate tissue repair

FEBRUARY 14, 2024byTampere UniversitySchematic diagram highlighting proposed mechanism of action of CAR peptide. Systemically administered CAR peptide associates with the HSPG SDC4, which is res

Wound-homing molecule found to accelerate tissue repair

FEBRUARY 14, 2024byTampere UniversitySchematic diagram highlighting proposed mechanism of action of CAR peptide. Systemically administered CAR peptide associates with the HSPG SDC4, which is res
Chronic Hepatitis B

Chronic Hepatitis B

RESEARCH29 January 2024New hepatitis B study reveals how viruses adapt to low-oxygen environments, such as those found deep within the liver, opening up possible new therapeutic targets for liver path

Chronic Hepatitis B

RESEARCH29 January 2024New hepatitis B study reveals how viruses adapt to low-oxygen environments, such as those found deep within the liver, opening up possible new therapeutic targets for liver path