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Breakthroughs
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Drug candidate granted FDA orphan drug status for pancreatic cancer

Drug candidate granted FDA orphan drug status for pancreatic cancer

by Roswell Park Comprehensive Cancer CenterCredit:Journal of Medicinal Chemistry(2023). DOI: 10.1021/acs.jmedchem.3c01589The U.S. Food and Drug Administration (FDA) has awarded Orphan Drug

Drug candidate granted FDA orphan drug status for pancreatic cancer

by Roswell Park Comprehensive Cancer CenterCredit:Journal of Medicinal Chemistry(2023). DOI: 10.1021/acs.jmedchem.3c01589The U.S. Food and Drug Administration (FDA) has awarded Orphan Drug
Anesthesia technology precisely controls unconsciousness in animal tests

Anesthesia technology precisely controls unconsciousness in animal tests

byMassachusetts Institute of TechnologySchematic of the propofol-based CLAD system for control of unconsciousness in an NHP. The user sets the target level of the marker of unconsciousness (MOU)

Anesthesia technology precisely controls unconsciousness in animal tests

byMassachusetts Institute of TechnologySchematic of the propofol-based CLAD system for control of unconsciousness in an NHP. The user sets the target level of the marker of unconsciousness (MOU)
Putting the brakes on chronic inflammation: Study discovers link between two key pathways

Putting the brakes on chronic inflammation: Study discovers link between two key pathways

by Weill Cornell Medical CollegeA single-cell atlas of IL-23 responses in the small intestine identifies CTLA-4+ILC3s. Credit:Nature(2024). DOI: 10.1038/s41586-024-07537-3Scient

Putting the brakes on chronic inflammation: Study discovers link between two key pathways

by Weill Cornell Medical CollegeA single-cell atlas of IL-23 responses in the small intestine identifies CTLA-4+ILC3s. Credit:Nature(2024). DOI: 10.1038/s41586-024-07537-3Scient
Chelation therapy does not improve outcomes after heart attack

Chelation therapy does not improve outcomes after heart attack

byAmerican College of CardiologyCredit: Pixabay/CC0 Public DomainPeople with diabetes who had suffered a heart attack derived no clinical benefit from edetate disodium-based chelation, a therapy

Chelation therapy does not improve outcomes after heart attack

byAmerican College of CardiologyCredit: Pixabay/CC0 Public DomainPeople with diabetes who had suffered a heart attack derived no clinical benefit from edetate disodium-based chelation, a therapy
'Suspended animation' drug could aid organ transplantation and survival from traumatic injury

'Suspended animation' drug could aid organ transplantation and survival from traumatic injury

by eLifeSNC80 uptake and activity at the delta opioid receptor. a. Distribution of SNC80 in Xenopus tadpoles after 1 and 2 hours of compound exposure. b. Uptake of SNC80 in the tadpole skeletal m

'Suspended animation' drug could aid organ transplantation and survival from traumatic injury

by eLifeSNC80 uptake and activity at the delta opioid receptor. a. Distribution of SNC80 in Xenopus tadpoles after 1 and 2 hours of compound exposure. b. Uptake of SNC80 in the tadpole skeletal m
Pharmacists could bridge a health care gap by offering more sexual health services

Pharmacists could bridge a health care gap by offering more sexual health services

by Adrianna MacPherson,University of AlbertaPharmacy professor and interim dean Christine Hughes is co-author of a study that suggests pharmacists are well positioned to play a key role in reduc

Pharmacists could bridge a health care gap by offering more sexual health services

by Adrianna MacPherson,University of AlbertaPharmacy professor and interim dean Christine Hughes is co-author of a study that suggests pharmacists are well positioned to play a key role in reduc
Medicinal plants help keep children healthy in South Africa: 61 species recorded

Medicinal plants help keep children healthy in South Africa: 61 species recorded

FEBRUARY 12, 2024by Tshepiso Ndhlovu, Abiodun Olusola Omotayo, Adeyemi Oladapo Aremu and Wilfred Otang-Mbeng,The ConversationThe common yellow commelina, one of the popular plants used to treat

Medicinal plants help keep children healthy in South Africa: 61 species recorded

FEBRUARY 12, 2024by Tshepiso Ndhlovu, Abiodun Olusola Omotayo, Adeyemi Oladapo Aremu and Wilfred Otang-Mbeng,The ConversationThe common yellow commelina, one of the popular plants used to treat
New insight into old IBD drug could improve treatments

New insight into old IBD drug could improve treatments

by Jim Schnabel,Cornell UniversityGraphical Abstract. Credit:Cell Reports Medicine(2024). DOI: 10.1016/j.xcrm.2024.101431Although it is one of the oldest medications used to treat pa

New insight into old IBD drug could improve treatments

by Jim Schnabel,Cornell UniversityGraphical Abstract. Credit:Cell Reports Medicine(2024). DOI: 10.1016/j.xcrm.2024.101431Although it is one of the oldest medications used to treat pa
ADHD drug shortages: What to expect if you take Vyvanse and can't access your usual dose

ADHD drug shortages: What to expect if you take Vyvanse and can't access your usual dose

by Alison Poulton,The ConversationCredit: Pixabay/CC0 Public DomainImagine you or your child has attention deficit hyperactivity disorder (ADHD), and after several weeks, or even months, you&#39

ADHD drug shortages: What to expect if you take Vyvanse and can't access your usual dose

by Alison Poulton,The ConversationCredit: Pixabay/CC0 Public DomainImagine you or your child has attention deficit hyperactivity disorder (ADHD), and after several weeks, or even months, you&#39
Scientists reveal new TEV-mediated αPD-L1-specific therapy resistance mechanism

Scientists reveal new TEV-mediated αPD-L1-specific therapy resistance mechanism

by Zhejiang UniversityTEV PD-L1 competes with PD-L1 on tumor cells to bind αPD-L1.a,bMC38-EVs and PC3-EVs (1 μg) (a) or MC38 and PC3 cells (1 × 105) (b) were coincubated with the ind

Scientists reveal new TEV-mediated αPD-L1-specific therapy resistance mechanism

by Zhejiang UniversityTEV PD-L1 competes with PD-L1 on tumor cells to bind αPD-L1.a,bMC38-EVs and PC3-EVs (1 μg) (a) or MC38 and PC3 cells (1 × 105) (b) were coincubated with the ind