Why is Alzheimer’s disease so difficult to treat?

Updated on: September 20,2024 0

Why is Alzheimer’s disease so difficult to treat?

Updated on:September 20,2024 0

New insight into old IBD drug could improve treatments

by Jim Schnabel,Cornell UniversityGraphical Abstract. Credit:Cell Reports Medicine(2024). DOI: 10.1016/j.xcrm.2024.101431Although it is one of the oldest medications used to treat pa

Updated on: March 30,2024 13

New insight into old IBD drug could improve treatments

by Jim Schnabel,Cornell UniversityGraphical Abstract. Credit:Cell Reports Medicine(2024). DOI: 10.1016/j.xcrm.2024.101431Although it is one of the oldest medications used to treat pa

Updated on:March 30,2024 13

Plastic particles harm gut health and immunity in mice, study shows

by Zhang Nannan,Chinese Academy of SciencesEffect of PS-MNPs on the intestinal structure of mice. Representative images of H&E staining of mouse intestinal tissue. (A) Intestine of mice afte

Updated on: December 26,2023 15

Plastic particles harm gut health and immunity in mice, study shows

by Zhang Nannan,Chinese Academy of SciencesEffect of PS-MNPs on the intestinal structure of mice. Representative images of H&E staining of mouse intestinal tissue. (A) Intestine of mice afte

Updated on:December 26,2023 15

Chelation therapy does not improve outcomes after heart attack

byAmerican College of CardiologyCredit: Pixabay/CC0 Public DomainPeople with diabetes who had suffered a heart attack derived no clinical benefit from edetate disodium-based chelation, a therapy

Updated on: April 28,2024 0

Chelation therapy does not improve outcomes after heart attack

byAmerican College of CardiologyCredit: Pixabay/CC0 Public DomainPeople with diabetes who had suffered a heart attack derived no clinical benefit from edetate disodium-based chelation, a therapy

Updated on:April 28,2024 0

Anesthesia technology precisely controls unconsciousness in animal tests

byMassachusetts Institute of TechnologySchematic of the propofol-based CLAD system for control of unconsciousness in an NHP. The user sets the target level of the marker of unconsciousness (MOU)

Updated on: January 04,2024 10

Anesthesia technology precisely controls unconsciousness in animal tests

byMassachusetts Institute of TechnologySchematic of the propofol-based CLAD system for control of unconsciousness in an NHP. The user sets the target level of the marker of unconsciousness (MOU)

Updated on:January 04,2024 10

Study finds ketamine effects outlast half-life by getting trapped in NMDA receptors

by Justin Jackson , Medical XpressSingle injection of ketamine no longer causes antidepressant effects on day 3 or day 7. Credit:Nature(2023). DOI: 10.1038/s41586-023-06624-1Researchers at

Updated on: January 10,2024 5

Study finds ketamine effects outlast half-life by getting trapped in NMDA receptors

by Justin Jackson , Medical XpressSingle injection of ketamine no longer causes antidepressant effects on day 3 or day 7. Credit:Nature(2023). DOI: 10.1038/s41586-023-06624-1Researchers at

Updated on:January 10,2024 5

JAMA report outlines recommendations for evaluation and management of penicillin allergy

by Massachusetts General HospitalCredit: CC0 Public DomainWhile more than 32 million individuals in the U.S. have a documented penicillin allergy in their medical record, studies have shown that

Updated on: April 16,2024 20

JAMA report outlines recommendations for evaluation and management of penicillin allergy

by Massachusetts General HospitalCredit: CC0 Public DomainWhile more than 32 million individuals in the U.S. have a documented penicillin allergy in their medical record, studies have shown that

Updated on:April 16,2024 20

Scientists reveal new TEV-mediated αPD-L1-specific therapy resistance mechanism

by Zhejiang UniversityTEV PD-L1 competes with PD-L1 on tumor cells to bind αPD-L1.a,bMC38-EVs and PC3-EVs (1 μg) (a) or MC38 and PC3 cells (1 × 105) (b) were coincubated with the ind

Updated on: December 27,2023 12

Scientists reveal new TEV-mediated αPD-L1-specific therapy resistance mechanism

by Zhejiang UniversityTEV PD-L1 competes with PD-L1 on tumor cells to bind αPD-L1.a,bMC38-EVs and PC3-EVs (1 μg) (a) or MC38 and PC3 cells (1 × 105) (b) were coincubated with the ind

Updated on:December 27,2023 12

Drug candidate granted FDA orphan drug status for pancreatic cancer

by Roswell Park Comprehensive Cancer CenterCredit:Journal of Medicinal Chemistry(2023). DOI: 10.1021/acs.jmedchem.3c01589The U.S. Food and Drug Administration (FDA) has awarded Orphan Drug

Updated on: April 23,2024 14

Drug candidate granted FDA orphan drug status for pancreatic cancer

by Roswell Park Comprehensive Cancer CenterCredit:Journal of Medicinal Chemistry(2023). DOI: 10.1021/acs.jmedchem.3c01589The U.S. Food and Drug Administration (FDA) has awarded Orphan Drug

Updated on:April 23,2024 14

Predicting correct dosage may improve success of drug repurposing

by Sarah Small,Pennsylvania State UniversityCredit:Cell Reports Medicine(2023). DOI: 10.1016/j.xcrm.2023.101227Before a drug can be used to treat a disease, it must go through a leng

Updated on: May 16,2024 6

Predicting correct dosage may improve success of drug repurposing

by Sarah Small,Pennsylvania State UniversityCredit:Cell Reports Medicine(2023). DOI: 10.1016/j.xcrm.2023.101227Before a drug can be used to treat a disease, it must go through a leng

Updated on:May 16,2024 6

Crack vaccine research on rats could help babies of mothers who use cocaine—and reduce addiction

by Frederico Garcia,The ConversationScintigraphy shows that many more cocaine molecules reached the brain of pregnant rats that received a placebo than those that received the vaccine. Credit: V

Updated on: April 23,2024 17

Crack vaccine research on rats could help babies of mothers who use cocaine—and reduce addiction

by Frederico Garcia,The ConversationScintigraphy shows that many more cocaine molecules reached the brain of pregnant rats that received a placebo than those that received the vaccine. Credit: V

Updated on:April 23,2024 17

Exploring complement system response to adeno-associated virus vector gene therapy

by Kathryn Ryan,Mary Ann Liebert, IncCredit: CC0 Public DomainRecent clinical trials utilizing high doses of adeno-associated virus (AAV) vectors have highlighted a new challenge to AAV gene tra

Updated on: June 18,2024 5

Exploring complement system response to adeno-associated virus vector gene therapy

by Kathryn Ryan,Mary Ann Liebert, IncCredit: CC0 Public DomainRecent clinical trials utilizing high doses of adeno-associated virus (AAV) vectors have highlighted a new challenge to AAV gene tra

Updated on:June 18,2024 5