CRISPR-based mapping uncovers 'switches' for immune genes central to health

byGladstone InstitutesTiling CRISPRi screens map gene-specific CREs across the costimulatory locus. Credit:Nature Genetics(2024). DOI: 10.1038/s41588-024-01743-5Healthy T cells are t

Updated on: May 30,2024

CRISPR-based mapping uncovers 'switches' for immune genes central to health

byGladstone InstitutesTiling CRISPRi screens map gene-specific CREs across the costimulatory locus. Credit:Nature Genetics(2024). DOI: 10.1038/s41588-024-01743-5Healthy T cells are t

Updated on:May 30,2024

Calcium channel blockers key to reversing myotonic dystrophy muscle weakness, study finds

byUniversity of Rochester Medical CenterCredit: Unsplash/CC0 Public DomainNew research has identified the specific biological mechanism behind the muscle dysfunction found in myotonic dystrophy

Updated on: January 26,2024

Calcium channel blockers key to reversing myotonic dystrophy muscle weakness, study finds

byUniversity of Rochester Medical CenterCredit: Unsplash/CC0 Public DomainNew research has identified the specific biological mechanism behind the muscle dysfunction found in myotonic dystrophy

Updated on:January 26,2024

Demystifying a key receptor in substance use and neuropsychiatric disorders

byThe Mount Sinai HospitalMount Sinai Icahn scientists took detailed pictures of how drugs can bind to the TAAR1 receptor using CryoEM. They also discovered that an antipsychotic drug, asenapine

Updated on: January 09,2024

Demystifying a key receptor in substance use and neuropsychiatric disorders

byThe Mount Sinai HospitalMount Sinai Icahn scientists took detailed pictures of how drugs can bind to the TAAR1 receptor using CryoEM. They also discovered that an antipsychotic drug, asenapine

Updated on:January 09,2024

Many antibiotic courses for common infections not in line with guidelines

by British Medical JournalCredit: CC0 Public DomainMany antibiotic courses prescribed for common infections treated in English primary care (general practices and community services) exceed the r

Updated on: March 06,2024

Many antibiotic courses for common infections not in line with guidelines

by British Medical JournalCredit: CC0 Public DomainMany antibiotic courses prescribed for common infections treated in English primary care (general practices and community services) exceed the r

Updated on:March 06,2024

Clinical trial highlights possible treatment for anemia in myelodysplastic neoplasms

by Anne Grimm,Leipzig UniversityCredit: Pixabay/CC0 Public DomainIn patients affected by myelodysplastic neoplasms, the body does not produce enough functional blood cells. Patients suffer from

Updated on: January 26,2024

Clinical trial highlights possible treatment for anemia in myelodysplastic neoplasms

by Anne Grimm,Leipzig UniversityCredit: Pixabay/CC0 Public DomainIn patients affected by myelodysplastic neoplasms, the body does not produce enough functional blood cells. Patients suffer from

Updated on:January 26,2024

A molecular route to decoding synaptic specificity and nerve cell communication

by Tokyo Institute of TechnologyThis study provides insights into the molecular mechanisms underlying the neuronal synaptic interaction. Credit: Tokyo TechNeurons or nerve cells are the fundament

Updated on: April 06,2024

A molecular route to decoding synaptic specificity and nerve cell communication

by Tokyo Institute of TechnologyThis study provides insights into the molecular mechanisms underlying the neuronal synaptic interaction. Credit: Tokyo TechNeurons or nerve cells are the fundament

Updated on:April 06,2024

Study supports use of cystic fibrosis drug in infants from four weeks of age

by RCSI University of Medicine and Health SciencesCredit: Pixabay/CC0 Public DomainA cystic fibrosis drug targeting the basic defect that causes the condition has been shown to be safe and effective i

Updated on: April 28,2024

Study supports use of cystic fibrosis drug in infants from four weeks of age

by RCSI University of Medicine and Health SciencesCredit: Pixabay/CC0 Public DomainA cystic fibrosis drug targeting the basic defect that causes the condition has been shown to be safe and effective i

Updated on:April 28,2024

Researchers race to develop Paxlovid replacement

by Andrew Smith,Rutgers UniversityX-ray crystal structure of the covalent inhibitor Jun11313 with SARS-CoV-2 PLproand structure-based design of biarylphenyl SARS-CoV-2 PLproinhibitor

Updated on: January 26,2024

Researchers race to develop Paxlovid replacement

by Andrew Smith,Rutgers UniversityX-ray crystal structure of the covalent inhibitor Jun11313 with SARS-CoV-2 PLproand structure-based design of biarylphenyl SARS-CoV-2 PLproinhibitor

Updated on:January 26,2024

Mechanical engineers develop miniaturized, hydrogel-based electric generators for biomedical devices

by The University of Hong KongThe hydrogel electric generator and its working mechanism. Credit: Nature Communications (2024). DOI: 10.1038/s41467-024-45931-7Mechanoelectrical energy conversion offers

Updated on: May 14,2024

Mechanical engineers develop miniaturized, hydrogel-based electric generators for biomedical devices

by The University of Hong KongThe hydrogel electric generator and its working mechanism. Credit: Nature Communications (2024). DOI: 10.1038/s41467-024-45931-7Mechanoelectrical energy conversion offers

Updated on:May 14,2024

New frontier in biomedical engineering: Protein coacervates engineered into adhesive for unprecedented skin repair speed

by Engineering(a) Schematic diagram of ECM composition. Elastin and growth factor are important components of the ECM. (b) Construction and expression of the protein. (c) Preparation of the EED adhesi

Updated on: January 06,2024

New frontier in biomedical engineering: Protein coacervates engineered into adhesive for unprecedented skin repair speed

by Engineering(a) Schematic diagram of ECM composition. Elastin and growth factor are important components of the ECM. (b) Construction and expression of the protein. (c) Preparation of the EED adhesi

Updated on:January 06,2024

Researchers present playbook of best practices for cancer team science in the modern era

by Break Through CancerThe Hallmarks of Cancer Collaboration. Based on Hanahan and Weinberg's seminal "Hallmarks of Cancer," this illustration proposes six Hallmarks of Cancer Collaborat

Updated on: April 06,2024

Researchers present playbook of best practices for cancer team science in the modern era

by Break Through CancerThe Hallmarks of Cancer Collaboration. Based on Hanahan and Weinberg's seminal "Hallmarks of Cancer," this illustration proposes six Hallmarks of Cancer Collaborat

Updated on:April 06,2024

White house could punish big pharma's high prices by removing patents

by Dennis ThompsonThe Biden administration is flexing some federal muscle in its push for lower drug prices, warning pharmaceutical companies that it might use its authority to cancel patent protectio

Updated on: January 26,2024

White house could punish big pharma's high prices by removing patents

by Dennis ThompsonThe Biden administration is flexing some federal muscle in its push for lower drug prices, warning pharmaceutical companies that it might use its authority to cancel patent protectio

Updated on:January 26,2024