Researcher identifies key mechanism in Parkinson's disease

by Anna Zarra Aldrich,University of ConnecticutProper regulation of LRRK2 levels is important for Parkinson's disease (PD). ATIC, a purine biosynthesis pathway enzyme, and its substrate prec

Updated on: March 13,2024

Researcher identifies key mechanism in Parkinson's disease

by Anna Zarra Aldrich,University of ConnecticutProper regulation of LRRK2 levels is important for Parkinson's disease (PD). ATIC, a purine biosynthesis pathway enzyme, and its substrate prec

Updated on:March 13,2024

What type of a relationship with an ancient person does a shared DNA fragment imply?

by Shai Carmi and Harald Ringbauer,The ConversationA comparison of one chromosome’s DNA sequence between a 14th-century German Jew and two living people who uploaded their DNA to GEDmatch. Each

Updated on: April 06,2024

What type of a relationship with an ancient person does a shared DNA fragment imply?

by Shai Carmi and Harald Ringbauer,The ConversationA comparison of one chromosome’s DNA sequence between a 14th-century German Jew and two living people who uploaded their DNA to GEDmatch. Each

Updated on:April 06,2024

Smarter blood tests could deliver faster diagnoses and improved outcomes

by Dalin Clark,Michigan State UniversitySmall molecule modulation of protein corona significantly enhances deep plasma proteome profiling. Credit: Mahmoudi GroupMedical professionals have long k

Updated on: December 04,2024

Smarter blood tests could deliver faster diagnoses and improved outcomes

by Dalin Clark,Michigan State UniversitySmall molecule modulation of protein corona significantly enhances deep plasma proteome profiling. Credit: Mahmoudi GroupMedical professionals have long k

Updated on:December 04,2024

Research provides further evidence that epigenetic changes can cause type 2 diabetes

byLund UniversityStudy design. EPIC array DNA methylation in islets of 25 T2D cases and 75 controls. RNA-seq data were available for 25 T2D cases and 72 controls. Islet DNA methylation was assoc

Updated on: March 13,2024

Research provides further evidence that epigenetic changes can cause type 2 diabetes

byLund UniversityStudy design. EPIC array DNA methylation in islets of 25 T2D cases and 75 controls. RNA-seq data were available for 25 T2D cases and 72 controls. Islet DNA methylation was assoc

Updated on:March 13,2024

Quest for personalized medicine hits a snag: Current models have limited effectiveness to predict treatments, says study

JANUARY 11, 2024by Bill Hathaway,Yale UniversityCredit: Unsplash/CC0 Public DomainThe quest for personalized medicine, a medical approach in which practitioners use a patient's unique geneti

Updated on: March 27,2024

Quest for personalized medicine hits a snag: Current models have limited effectiveness to predict treatments, says study

JANUARY 11, 2024by Bill Hathaway,Yale UniversityCredit: Unsplash/CC0 Public DomainThe quest for personalized medicine, a medical approach in which practitioners use a patient's unique geneti

Updated on:March 27,2024

UK issues guidelines for use of stem cell-based embryo models in research

byUniversity of CambridgeThese models can be created in the lab and mimic aspects of early human embryo development, which raises various ethical considerations. Credit: Irene Zorzan and Teresa

Updated on: July 05,2024

UK issues guidelines for use of stem cell-based embryo models in research

byUniversity of CambridgeThese models can be created in the lab and mimic aspects of early human embryo development, which raises various ethical considerations. Credit: Irene Zorzan and Teresa

Updated on:July 05,2024

Disruption of mitochondrial unfolded protein response yields shortening of telomeres in mouse oocytes, somatic cells

FEBRUARY 21, 2024by Impact Journals LLCRepresentative confocal images of TRF1 expression and TRF/H2AX co-localization in cumulus oophorus isolated from 6-month-old wild-type and Clpp−/−mice. Cre

Updated on: March 30,2024

Disruption of mitochondrial unfolded protein response yields shortening of telomeres in mouse oocytes, somatic cells

FEBRUARY 21, 2024by Impact Journals LLCRepresentative confocal images of TRF1 expression and TRF/H2AX co-localization in cumulus oophorus isolated from 6-month-old wild-type and Clpp−/−mice. Cre

Updated on:March 30,2024

Researchers uncover 'circular logic' of RNAs in Parkinson's disease

byBrigham and Women's HospitalScherzer and colleagues laser-captured neurons from 190 frozen postmortem human brain samples, including some non-neuronal cells for comparison. Then, they used

Updated on: March 13,2024

Researchers uncover 'circular logic' of RNAs in Parkinson's disease

byBrigham and Women's HospitalScherzer and colleagues laser-captured neurons from 190 frozen postmortem human brain samples, including some non-neuronal cells for comparison. Then, they used

Updated on:March 13,2024

Blended antioxidant supplement found to improve cognition and memory in aged mice

by Shibaura Institute of TechnologyAdministration of Twendee X (TwX) improves spatial learning ability in aged mice. The spatial cognition test's average goal time (escape latency) is shown i

Updated on: April 06,2024

Blended antioxidant supplement found to improve cognition and memory in aged mice

by Shibaura Institute of TechnologyAdministration of Twendee X (TwX) improves spatial learning ability in aged mice. The spatial cognition test's average goal time (escape latency) is shown i

Updated on:April 06,2024

Mature 'lab grown' neurons hold promise for neurodegenerative disease

by Northwestern UniversityFluorescent images of human neurons (stained with red, green and blue) growing on coatings with fast-moving molecules (left) or conventional laminin (right) for 72 hours

Updated on: February 05,2024

Mature 'lab grown' neurons hold promise for neurodegenerative disease

by Northwestern UniversityFluorescent images of human neurons (stained with red, green and blue) growing on coatings with fast-moving molecules (left) or conventional laminin (right) for 72 hours

Updated on:February 05,2024

Perfecting 3D-printed blood vessels with pores

JANUARY 17, 2024byPohang University of Science and TechnologyFabrication process of S-SDVs and the results of HUVECs migration through pores. Credit: POSTECHDue to the substantial clinical deman

Updated on: March 25,2024

Perfecting 3D-printed blood vessels with pores

JANUARY 17, 2024byPohang University of Science and TechnologyFabrication process of S-SDVs and the results of HUVECs migration through pores. Credit: POSTECHDue to the substantial clinical deman

Updated on:March 25,2024

Genetics may influence the body's response to low oxygen, study finds

byUniversity of PittsburghImmunofluorescent staining for the lncRNA fragment in a diseased pulmonary vessel from a patient with pulmonary arterial hypertension. Credit: Thomas BerteroUniversity

Updated on: March 13,2024

Genetics may influence the body's response to low oxygen, study finds

byUniversity of PittsburghImmunofluorescent staining for the lncRNA fragment in a diseased pulmonary vessel from a patient with pulmonary arterial hypertension. Credit: Thomas BerteroUniversity

Updated on:March 13,2024