by Brown University

Spatial correlations of enterovirus outbreaks and climate. A Maps showing the mean timing of cases in terms of week-of-year of polio outbreaks in the USA, EVA71 outbreaks in mainland China, CVA16 outbreaks in mainland China. B Scatter plot of mean annual temperature for US state or Chinese province against mean timing of cases for polio, EVA71, and CVA16. Local polynomial regression line is shown in black with 95% confidence intervals (CVA16, EVA71, n = 31; polio, n = 49). C Normalized average weekly cases of polio in the USA and EVA71 in mainland China and Japan. Locations are ordered by latitude. Supplementary Fig. 1 shows the result for CVA16. D Scatter plot of average temperature range (mean max.–mean. min) and epidemic intensity (see “Methods”) for polio, EVA71, and CVA16. Again, each point indicates a US state or Chinese province. Credit: Nature Communications (2024). DOI: 10.1038/s41467-024-50936-3

Outbreaks of hand, foot and mouth disease (HFMD), which causes fever and rash in young children, typically occur in the summer months. Similarly, historic cases of polio were observed in the summer months in the United States. Both diseases are caused by different species of enteroviruses, a large genus of RNA viruses. However, the drivers of the seasonal patterns of these diseases have remained somewhat unclear.

A common set of drivers can explain the timing of outbreaks of both HFMD and polio according a recent study by researchers at Brown University, Princeton University and Johns Hopkins, published in Nature Communications. Further, these summertime outbreaks may hint at implications for climate change.

"We find, even after controlling for other factors, that temperature appears to increase enterovirus transmission," said first author Rachel Baker, the John and Elizabeth Irving Family Assistant Professor of Climate and Health at Brown University. "Crucially, we see a similar-sized effect for polio historically, and more recent enteroviruses serotypes that cause HFMD."

"Enterovirus outbreaks exhibit clear patterns over space," noted co-author Saki Takahashi, Assistant Professor of Epidemiology at Johns Hopkins University who has previously studied the outbreak dynamics of enteroviruses in both China and Japan. "At higher latitudes we see large outbreaks of HFMD every two or three years, but closer to the tropics we observe outbreaks twice a year—our results are able to capture these large scale patterns."

Baker and co-authors used an epidemiological model to show that temperature and demographic drivers, specifically the timing of school semesters, can explain the two HFMD outbreaks a year in southern China. In more northern locations, the temperature effect dominates and the schooling effect disappears.

"What really matters is the seasonal range of climate, i.e. the maximum temperature and minimum temperature," said co-author Wenchang Yang, Associate Research Scholar of Geosciences at Princeton University. "That might have implications for how we think about the future effects."

The authors used their model to consider the implications of climate change for enterovirus outbreaks using output from 14 different climate models.

"A key finding is the impact of variability," said co-author Gabriel Vecchi, the Knox Taylor Professor of Geosciences and Director of the High Meadows Environmental Institute at Princeton University. "The impact of climate variability on disease dynamics is underexplored, and this study represents a clear advance in the needed exploration of this topic."

The authors found that climate change could increase the peak size of enterovirus outbreaks by up to 40%, but effects vary by location and climate model. Improved surveillance of enterovirus circulation could help track these possible impacts.

"Serological surveys are vital for tracking susceptibility to enteroviruses and other pathogens," said Takahashi.

More information: Rachel E. Baker et al, Increasing intensity of enterovirus outbreaks projected with climate change, Nature Communications (2024). DOI: 10.1038/s41467-024-50936-3

Journal information: Nature Communications 

Provided by Brown University