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Hematology&Oncology
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Common medicines may influence CRISPR therapy outcomes and precision cancer treatment

Common medicines may influence CRISPR therapy outcomes and precision cancer treatment

byMax Planck SocietyDrug screening for DSB repair pathway modulators. Credit:Nature Communications(2025). DOI: 10.1038/s41467-025-67243-0In a new study, scientists at the Max Planck Institute for Evol

Common medicines may influence CRISPR therapy outcomes and precision cancer treatment

byMax Planck SocietyDrug screening for DSB repair pathway modulators. Credit:Nature Communications(2025). DOI: 10.1038/s41467-025-67243-0In a new study, scientists at the Max Planck Institute for Evol
Combination treatment may help cut lifelong ibrutinib for chronic lymphocytic leukemia patients

Combination treatment may help cut lifelong ibrutinib for chronic lymphocytic leukemia patients

byAmerican Association for Cancer ResearchCredit: Pixabay/CC0 Public DomainChronic lymphocytic leukemia (CLL) is the most prevalent adult leukemia in the Western Hemisphere, affecting approximately 20

Combination treatment may help cut lifelong ibrutinib for chronic lymphocytic leukemia patients

byAmerican Association for Cancer ResearchCredit: Pixabay/CC0 Public DomainChronic lymphocytic leukemia (CLL) is the most prevalent adult leukemia in the Western Hemisphere, affecting approximately 20
Combination therapy for pancreatic cancer offers new treatment approach

Combination therapy for pancreatic cancer offers new treatment approach

by Lena Bösch,University Medical Center GöttingenMini tumor models from patient-derived tissue, known as organoids, without and with therapy. Bottom: Tumors (blue) with macrophages (yellow)—immune cel

Combination therapy for pancreatic cancer offers new treatment approach

by Lena Bösch,University Medical Center GöttingenMini tumor models from patient-derived tissue, known as organoids, without and with therapy. Bottom: Tumors (blue) with macrophages (yellow)—immune cel
Combination therapy shows potential to treat pediatric brain cancer ATRT

Combination therapy shows potential to treat pediatric brain cancer ATRT

bySt. Jude Children's Research HospitalAs published inNeuro-Oncology Pediatrics, a combination therapy may offer a new treatment strategy for atypical teratoid rhabdoid tumor (ATRT), a rare pediat

Combination therapy shows potential to treat pediatric brain cancer ATRT

bySt. Jude Children's Research HospitalAs published inNeuro-Oncology Pediatrics, a combination therapy may offer a new treatment strategy for atypical teratoid rhabdoid tumor (ATRT), a rare pediat
Colorectal cancer's immune puzzle cracked: Two Treg cell types shape survival odds

Colorectal cancer's immune puzzle cracked: Two Treg cell types shape survival odds

by Ian Demsky,Memorial Sloan Kettering Cancer CenterCredit: Unsplash/CC0 Public DomainIn most solid tumors, high numbers of regulatory T (Treg) cells are associated with poorer outcomes because they d

Colorectal cancer's immune puzzle cracked: Two Treg cell types shape survival odds

by Ian Demsky,Memorial Sloan Kettering Cancer CenterCredit: Unsplash/CC0 Public DomainIn most solid tumors, high numbers of regulatory T (Treg) cells are associated with poorer outcomes because they d
Clinical trial of personalized cancer vaccine demonstrates feasibility, safety, immune activation

Clinical trial of personalized cancer vaccine demonstrates feasibility, safety, immune activation

byHarvard UniversityThe personalized biomaterial-based cancer vaccine consists of a porous biomaterial scaffold the size of an aspirin tablet that is infused with immune cell-recruiting and activating

Clinical trial of personalized cancer vaccine demonstrates feasibility, safety, immune activation

byHarvard UniversityThe personalized biomaterial-based cancer vaccine consists of a porous biomaterial scaffold the size of an aspirin tablet that is infused with immune cell-recruiting and activating
Cancer's hidden 'safety switch': Silencing TAK1 gene could boost immunotherapy performance

Cancer's hidden 'safety switch': Silencing TAK1 gene could boost immunotherapy performance

byLa Trobe UniversityCredit: Pixabay/CC0 Public DomainAustralian researchers have discovered that the TAK1 gene helps cancer cells survive attack from the immune system, revealing a mechanism that may

Cancer's hidden 'safety switch': Silencing TAK1 gene could boost immunotherapy performance

byLa Trobe UniversityCredit: Pixabay/CC0 Public DomainAustralian researchers have discovered that the TAK1 gene helps cancer cells survive attack from the immune system, revealing a mechanism that may
Cancer messenger substances disrupt muscle function and trigger muscle breakdown

Cancer messenger substances disrupt muscle function and trigger muscle breakdown

by Inka Burow,Hannover Medical SchoolDr Arnab Nayak, private lecturer, investigates the effect of pro-inflammatory messengers on muscle wasting in cancer. Credit: Tim Holler/MHHCancer patients often l

Cancer messenger substances disrupt muscle function and trigger muscle breakdown

by Inka Burow,Hannover Medical SchoolDr Arnab Nayak, private lecturer, investigates the effect of pro-inflammatory messengers on muscle wasting in cancer. Credit: Tim Holler/MHHCancer patients often l
Blood test can detect single lung cancer calls using infrared technique

Blood test can detect single lung cancer calls using infrared technique

by Meg Cox,Loughborough UniversityThis figure shows how the technique identifies a single circulating tumor cell (CTC) in a lung cancer patient's blood sample. The sample is first viewed under a m

Blood test can detect single lung cancer calls using infrared technique

by Meg Cox,Loughborough UniversityThis figure shows how the technique identifies a single circulating tumor cell (CTC) in a lung cancer patient's blood sample. The sample is first viewed under a m
Black patients diagnosed with aggressive leukemia experience worse outcomes

Black patients diagnosed with aggressive leukemia experience worse outcomes

byUniversity of Maryland School of MedicineCredit: Ninthgrid from PexelsCompared with white patients, Black patients with an aggressive form of leukemia—called acute myeloid leukemia (AML)—were on ave

Black patients diagnosed with aggressive leukemia experience worse outcomes

byUniversity of Maryland School of MedicineCredit: Ninthgrid from PexelsCompared with white patients, Black patients with an aggressive form of leukemia—called acute myeloid leukemia (AML)—were on ave
Blood analysis shows whether brain cancer treatment is working

Blood analysis shows whether brain cancer treatment is working

by Kate McAlpine,University of MichiganDesign and validation ofGlioExoChip using EVPs from GBM cell lines. Credit:Nature Communications(2025). DOI: 10.1038/s41467-025-65681-4The effectiveness of chemo

Blood analysis shows whether brain cancer treatment is working

by Kate McAlpine,University of MichiganDesign and validation ofGlioExoChip using EVPs from GBM cell lines. Credit:Nature Communications(2025). DOI: 10.1038/s41467-025-65681-4The effectiveness of chemo
Alcohol-linked DNA damage tied to cancer risk: Study reveals repair enzyme's role

Alcohol-linked DNA damage tied to cancer risk: Study reveals repair enzyme's role

byInstitute of Organic Chemistry and Biochemistry of the CASModel of alcohol metabolism leading to acetaldehyde interstrand crosslink (AA-ICL). Credit:Communications Biology(2025). DOI: 10.1038/s42003

Alcohol-linked DNA damage tied to cancer risk: Study reveals repair enzyme's role

byInstitute of Organic Chemistry and Biochemistry of the CASModel of alcohol metabolism leading to acetaldehyde interstrand crosslink (AA-ICL). Credit:Communications Biology(2025). DOI: 10.1038/s42003