A TREM2 activating antibody with a transport vehicle that could boost the metabolism and function of brain microglia

by Ingrid Fadelli , Medical XpressImages showing the architecture of our ATV:TREM2 molecule (a) images showing elevation of microglia proliferation in the brain of mice treated with ATV:TREM2 (b) a su

Updated on: March 26,2024 15

A TREM2 activating antibody with a transport vehicle that could boost the metabolism and function of brain microglia

by Ingrid Fadelli , Medical XpressImages showing the architecture of our ATV:TREM2 molecule (a) images showing elevation of microglia proliferation in the brain of mice treated with ATV:TREM2 (b) a su

Updated on:March 26,2024 15

Early-life stress can disrupt maturation of brain's reward circuits, promoting disorders

by University of California, IrvineA projection of CRH/GABA neurons in the medial BLA to the medial NAc shell.a–cRetrograde tracing of CRH+neuronal inputs to medial NAc shell of

Updated on: March 26,2024 14

Early-life stress can disrupt maturation of brain's reward circuits, promoting disorders

by University of California, IrvineA projection of CRH/GABA neurons in the medial BLA to the medial NAc shell.a–cRetrograde tracing of CRH+neuronal inputs to medial NAc shell of

Updated on:March 26,2024 14

New drugs cross blood-brain barrier to slow progression and even reverse symptoms of Huntington's disease

FEBRUARY 26, 2024byWeizmann Institute of ScienceCredit:EMBO Molecular Medicine(2024). DOI: 10.1038/s44321-023-00020-yWeizmann Institute scientists have discovered two small molecules

Updated on: March 25,2024 6

New drugs cross blood-brain barrier to slow progression and even reverse symptoms of Huntington's disease

FEBRUARY 26, 2024byWeizmann Institute of ScienceCredit:EMBO Molecular Medicine(2024). DOI: 10.1038/s44321-023-00020-yWeizmann Institute scientists have discovered two small molecules

Updated on:March 25,2024 6

Cell engineering team links cancer drug to potential therapy for Alzheimer's disease

FEBRUARY 23, 2024byJohns Hopkins UniversityNeurons that express Lag3 proteins (grey/white) can take in Tau proteins (red) compared with neighboring neurons that do not express Lag3. Credit: Xiao

Updated on: March 25,2024 11

Cell engineering team links cancer drug to potential therapy for Alzheimer's disease

FEBRUARY 23, 2024byJohns Hopkins UniversityNeurons that express Lag3 proteins (grey/white) can take in Tau proteins (red) compared with neighboring neurons that do not express Lag3. Credit: Xiao

Updated on:March 25,2024 11

Neurobiologists successfully test novel drug principle in a mouse model and in brain organoids of ALS patients

FEBRUARY 8, 2024by Marietta Fuhrmann-Koch,Heidelberg UniversityGraphical abstract. Credit:Cell Reports Medicine(2024). DOI: 10.1016/j.xcrm.2024.101413A research team led by Prof. Dr.

Updated on: March 25,2024 13

Neurobiologists successfully test novel drug principle in a mouse model and in brain organoids of ALS patients

FEBRUARY 8, 2024by Marietta Fuhrmann-Koch,Heidelberg UniversityGraphical abstract. Credit:Cell Reports Medicine(2024). DOI: 10.1016/j.xcrm.2024.101413A research team led by Prof. Dr.

Updated on:March 25,2024 13

Molecular clusters on glial cells show they are more than our brain's 'glue'

FEBRUARY 28, 2024byFred Hutchinson Cancer CenterGraphical abstract. Credit:Cell Reports(2024). DOI: 10.1016/j.celrep.2024.113844Neuroscientists at Fred Hutchinson Cancer Center have

Updated on: March 25,2024 11

Molecular clusters on glial cells show they are more than our brain's 'glue'

FEBRUARY 28, 2024byFred Hutchinson Cancer CenterGraphical abstract. Credit:Cell Reports(2024). DOI: 10.1016/j.celrep.2024.113844Neuroscientists at Fred Hutchinson Cancer Center have

Updated on:March 25,2024 11

A novel immunotherapy proves effective in animal models of multiple sclerosis

by Thomas Jefferson UniversityThe purified oligodendrocyte extracellular vesicles under an electron microscope. Credit: G. Casella et al., Science Translational Medicine (2020)Multiple sclerosis

Updated on: March 25,2024 14

A novel immunotherapy proves effective in animal models of multiple sclerosis

by Thomas Jefferson UniversityThe purified oligodendrocyte extracellular vesicles under an electron microscope. Credit: G. Casella et al., Science Translational Medicine (2020)Multiple sclerosis

Updated on:March 25,2024 14

A new treatment reduces inflammation in multiple sclerosis mice models

by Autonomous University of BarcelonaMaR1 reduces pro-inflammatory cytokines in the spinal cord of EAE mice. Plot showing the fold change in cytokine protein levels of different cytokines in the

Updated on: March 25,2024 18

A new treatment reduces inflammation in multiple sclerosis mice models

by Autonomous University of BarcelonaMaR1 reduces pro-inflammatory cytokines in the spinal cord of EAE mice. Plot showing the fold change in cytokine protein levels of different cytokines in the

Updated on:March 25,2024 18

60 years later, high school quality may have a long-term impact on cognition

by Columbia University Irving Medical CenterCredit: Unsplash/CC0 Public DomainA study of more than 2,200 adults who attended U.S. high schools in the early 1960s found that those who attended hig

Updated on: March 24,2024 16

60 years later, high school quality may have a long-term impact on cognition

by Columbia University Irving Medical CenterCredit: Unsplash/CC0 Public DomainA study of more than 2,200 adults who attended U.S. high schools in the early 1960s found that those who attended hig

Updated on:March 24,2024 16

Good heart health at age 50 linked to lower dementia risk later in life

by British Medical JournalCredit: CC0 Public DomainGood cardiovascular health at age 50 is associated with a lower risk of dementia later in life, finds a study of British adults published by&nbs

Updated on: March 24,2024 16

Good heart health at age 50 linked to lower dementia risk later in life

by British Medical JournalCredit: CC0 Public DomainGood cardiovascular health at age 50 is associated with a lower risk of dementia later in life, finds a study of British adults published by&nbs

Updated on:March 24,2024 16

Psychological well-being at 52 years could impact on cognitive functioning at 69 years

by IOS PressCredit: CC0 Public DomainPeople around the world are living longer, and dementia has consequently become recognized as a public health priority in many countries. The Lancet Commissio

Updated on: March 24,2024 11

Psychological well-being at 52 years could impact on cognitive functioning at 69 years

by IOS PressCredit: CC0 Public DomainPeople around the world are living longer, and dementia has consequently become recognized as a public health priority in many countries. The Lancet Commissio

Updated on:March 24,2024 11

New research shows men sleep better than women, and sleep quality improves with age

by Prabhjot Sohal,University of Western OntarioCredit: CC0 Public DomainResearchers have unveiled crucial insights into the sleep health of middle-aged and older adults in Canada, identifying so

Updated on: March 24,2024 12

New research shows men sleep better than women, and sleep quality improves with age

by Prabhjot Sohal,University of Western OntarioCredit: CC0 Public DomainResearchers have unveiled crucial insights into the sleep health of middle-aged and older adults in Canada, identifying so

Updated on:March 24,2024 12