GluN3A knockout mouse: Alternative model for Alzheimer's neurodegeneration

by Emory UniversityGluN3A (in the diagram, NR3) is an inhibitory subunit within NMDA receptor assemblies, which function as glutamate-gated cation channels. GluN3A is a key regulator of neuronal

Updated on: March 30,2024

GluN3A knockout mouse: Alternative model for Alzheimer's neurodegeneration

by Emory UniversityGluN3A (in the diagram, NR3) is an inhibitory subunit within NMDA receptor assemblies, which function as glutamate-gated cation channels. GluN3A is a key regulator of neuronal

Updated on:March 30,2024

Spinal fluid of people with Alzheimer's risk gene signals inflammation

by Duke University Medical CenterCredit: Pixabay/CC0 Public DomainPeople who have a gene variant associated with an increased risk of developing Alzheimer's disease also tend to have changes

Updated on: April 20,2024

Spinal fluid of people with Alzheimer's risk gene signals inflammation

by Duke University Medical CenterCredit: Pixabay/CC0 Public DomainPeople who have a gene variant associated with an increased risk of developing Alzheimer's disease also tend to have changes

Updated on:April 20,2024

Predicting change in the Alzheimer's brain

by Larry Hardesty,Massachusetts Institute of TechnologyMIT researchers are developing a computer system that uses genetic, demographic, and clinical data to help predict the effects of disease o

Updated on: February 26,2024

Predicting change in the Alzheimer's brain

by Larry Hardesty,Massachusetts Institute of TechnologyMIT researchers are developing a computer system that uses genetic, demographic, and clinical data to help predict the effects of disease o

Updated on:February 26,2024

Detecting diminished dopamine-firing cells inside brain could reveal earliest signs of Alzheimer's

by University of SheffieldPET scan of a human brain with Alzheimer's disease. Credit: public domainA new link between diminished input from dopamine-firing cells deep inside the brain and the

Updated on: June 20,2024

Detecting diminished dopamine-firing cells inside brain could reveal earliest signs of Alzheimer's

by University of SheffieldPET scan of a human brain with Alzheimer's disease. Credit: public domainA new link between diminished input from dopamine-firing cells deep inside the brain and the

Updated on:June 20,2024

Couch potatoes face same chance of dementia as those with genetic risk factors

by McMaster UniversityJennifer Heisz, assistant professor of kinesiology, McMaster University Credit: McMaster UniversitySedentary older adults with no genetic risk factors for dementia may be ju

Updated on: March 09,2024

Couch potatoes face same chance of dementia as those with genetic risk factors

by McMaster UniversityJennifer Heisz, assistant professor of kinesiology, McMaster University Credit: McMaster UniversitySedentary older adults with no genetic risk factors for dementia may be ju

Updated on:March 09,2024

Insulin signaling failures in the brain linked to Alzheimer's disease

by Joslin Diabetes CenterC. Ronald Kahn, Chief Academic Officer at Joslin Diabetes Center, and Mary K. Iacocca Professor of Medicine at Harvard Medical School Credit: Joslin CommunicationsScienti

Updated on: May 18,2024

Insulin signaling failures in the brain linked to Alzheimer's disease

by Joslin Diabetes CenterC. Ronald Kahn, Chief Academic Officer at Joslin Diabetes Center, and Mary K. Iacocca Professor of Medicine at Harvard Medical School Credit: Joslin CommunicationsScienti

Updated on:May 18,2024

Study confirms cognitive deficits in people with the rare disease MOGAD

by Stefan Zorn, Medizinische Hochschule HannoverMean z-scores of neuropsychological tests at baseline (patients <60 years). PASAT, Paced Auditory Serial Addition Task; SDMT, Symbol Digit Modalities

Updated on: November 12,2024

Study confirms cognitive deficits in people with the rare disease MOGAD

by Stefan Zorn, Medizinische Hochschule HannoverMean z-scores of neuropsychological tests at baseline (patients <60 years). PASAT, Paced Auditory Serial Addition Task; SDMT, Symbol Digit Modalities

Updated on:November 12,2024

'Anti-tangle' molecule could aid search for new dementia treatments, say scientists

by Vicky Just,University of BathThe solution NMR structure of αS1–25(A) The average structure of αS1–25derived from the 20 lowest-energy structures. Charged (blue: positive, red: negative)

Updated on: March 02,2024

'Anti-tangle' molecule could aid search for new dementia treatments, say scientists

by Vicky Just,University of BathThe solution NMR structure of αS1–25(A) The average structure of αS1–25derived from the 20 lowest-energy structures. Charged (blue: positive, red: negative)

Updated on:March 02,2024

Modulating brain's stress circuity might prevent Alzheimer's disease

by University of California - San DiegoDiagram of the brain of a person with Alzheimer's Disease. Credit: Wikipedia/public domain.In a novel animal study design that mimicked human clinical t

Updated on: February 27,2024

Modulating brain's stress circuity might prevent Alzheimer's disease

by University of California - San DiegoDiagram of the brain of a person with Alzheimer's Disease. Credit: Wikipedia/public domain.In a novel animal study design that mimicked human clinical t

Updated on:February 27,2024

Rocky start for Alzheimer's drug research in 2018

An Alzheimer sufferer models a creation by designer Guio Di Colombia during the Walkway Inclusion fashion show in Colombia last NovemberThe year 2018, barely underway, has already dealt a series of di

Updated on: March 19,2024

Rocky start for Alzheimer's drug research in 2018

An Alzheimer sufferer models a creation by designer Guio Di Colombia during the Walkway Inclusion fashion show in Colombia last NovemberThe year 2018, barely underway, has already dealt a series of di

Updated on:March 19,2024

Exercising can protect the brain from Alzheimer's disease

by University of British ColumbiaKathleen Martin Ginis is a professor in UBC Okanagan's School of Heath and Exercise Sciences. Credit: UBC OkanaganThe evidence is clear. Physical activity is

Updated on: March 09,2024

Exercising can protect the brain from Alzheimer's disease

by University of British ColumbiaKathleen Martin Ginis is a professor in UBC Okanagan's School of Heath and Exercise Sciences. Credit: UBC OkanaganThe evidence is clear. Physical activity is

Updated on:March 09,2024

Common degenerative brain disease may begin to develop already in middle age

byUniversity of HelsinkiImmunohistochemical staining with 5G4 antibody against alpha-synuclein in the Tampere Sudden Death Study cohort. Black arrowheads highlight LBs and gray arrowheads point

Updated on: March 28,2024

Common degenerative brain disease may begin to develop already in middle age

byUniversity of HelsinkiImmunohistochemical staining with 5G4 antibody against alpha-synuclein in the Tampere Sudden Death Study cohort. Black arrowheads highlight LBs and gray arrowheads point

Updated on:March 28,2024