Chaperone protein imbalance promotes toxic tau buildup in the aging brain

by University of South FloridaTau pathology resembling that seen in Alzheimer's disease brains. Credit: Laura Blair's laboratory, USF Health/University of South FloridaChaperone protein i

Updated on: April 25,2024

Chaperone protein imbalance promotes toxic tau buildup in the aging brain

by University of South FloridaTau pathology resembling that seen in Alzheimer's disease brains. Credit: Laura Blair's laboratory, USF Health/University of South FloridaChaperone protein i

Updated on:April 25,2024

Tau PET: A window into the future of Alzheimer's patients

by University of GenevaTau imaging with 18F-Flortaucipir PET in Alzheimer’s disease. The figure shows a prototypical tau accumulation pattern, obtained by comparing tau load of patients with Alzh

Updated on: April 02,2024

Tau PET: A window into the future of Alzheimer's patients

by University of GenevaTau imaging with 18F-Flortaucipir PET in Alzheimer’s disease. The figure shows a prototypical tau accumulation pattern, obtained by comparing tau load of patients with Alzh

Updated on:April 02,2024

A new treatment reduces inflammation in multiple sclerosis mice models

by Autonomous University of BarcelonaMaR1 reduces pro-inflammatory cytokines in the spinal cord of EAE mice. Plot showing the fold change in cytokine protein levels of different cytokines in the

Updated on: March 25,2024

A new treatment reduces inflammation in multiple sclerosis mice models

by Autonomous University of BarcelonaMaR1 reduces pro-inflammatory cytokines in the spinal cord of EAE mice. Plot showing the fold change in cytokine protein levels of different cytokines in the

Updated on:March 25,2024

Phase I clinical trial shows treatment designed to clear senescent cells in Alzheimer's disease is safe

by Atrium Health Wake Forest BaptistSenescent neurons are represented by areas of blue, red and white. Senescent cells are old, sick cells that cannot properly repair themselves and don't die

Updated on: March 02,2024

Phase I clinical trial shows treatment designed to clear senescent cells in Alzheimer's disease is safe

by Atrium Health Wake Forest BaptistSenescent neurons are represented by areas of blue, red and white. Senescent cells are old, sick cells that cannot properly repair themselves and don't die

Updated on:March 02,2024

Novel Rett syndrome variant shines light on new screening strategies for therapies

byTexas Children's HospitalMeCP2 protein level is reduced in the patient fibroblast-derived neurons. (A) Diagram of MeCP2 protein with the G118E mutation in the methyl-CpG binding domain (MB

Updated on: January 11,2024

Novel Rett syndrome variant shines light on new screening strategies for therapies

byTexas Children's HospitalMeCP2 protein level is reduced in the patient fibroblast-derived neurons. (A) Diagram of MeCP2 protein with the G118E mutation in the methyl-CpG binding domain (MB

Updated on:January 11,2024

Sounding the alarm on a future Alzheimer's disease epidemic

by Carla Denly,University of California, Los AngelesWe're living longer. The number of U.S. adults 65 and older—roughly 40 million as of the 2010 census—is expected to nearly double to 71 mi

Updated on: February 27,2024

Sounding the alarm on a future Alzheimer's disease epidemic

by Carla Denly,University of California, Los AngelesWe're living longer. The number of U.S. adults 65 and older—roughly 40 million as of the 2010 census—is expected to nearly double to 71 mi

Updated on:February 27,2024

Exploring neurons' molecular highways: How a key protein regulates neuronal health

byOkinawa Institute of Science and TechnologyDynein is composed of two heavy chains (blue), two intermediate chains (yellow), four light intermediate chains (green) and several light chains, inc

Updated on: January 12,2024

Exploring neurons' molecular highways: How a key protein regulates neuronal health

byOkinawa Institute of Science and TechnologyDynein is composed of two heavy chains (blue), two intermediate chains (yellow), four light intermediate chains (green) and several light chains, inc

Updated on:January 12,2024

How different flavors of inhibition save the day

by Irina Epstein,Max Planck SocietyCredit: Pixabay/CC0 Public DomainDuring development, lack of sensory experience elicits powerful plasticity mechanisms that alter brain circuitry. Many inhibit

Updated on: February 03,2024

How different flavors of inhibition save the day

by Irina Epstein,Max Planck SocietyCredit: Pixabay/CC0 Public DomainDuring development, lack of sensory experience elicits powerful plasticity mechanisms that alter brain circuitry. Many inhibit

Updated on:February 03,2024

Three-minute test detects common form of dementia that's hard to diagnose

by Florida Atlantic UniversityJames E. Galvin, M.D., M.P.H., one of the most prominent neuroscientists in the country, and a professor in FAU's Charles E. Schmidt College of Medicine and Chri

Updated on: February 26,2024

Three-minute test detects common form of dementia that's hard to diagnose

by Florida Atlantic UniversityJames E. Galvin, M.D., M.P.H., one of the most prominent neuroscientists in the country, and a professor in FAU's Charles E. Schmidt College of Medicine and Chri

Updated on:February 26,2024

Altered brain morphology and functional connectivity in postmenopausal women

by Impact Journals LLCBetween-group comparison map (premenopausal women vs. postmenopausal women) of the left mOFC functional connectivity. Credit:Aging(2024). DOI: 10.18632/aging.205662A

Updated on: April 06,2024

Altered brain morphology and functional connectivity in postmenopausal women

by Impact Journals LLCBetween-group comparison map (premenopausal women vs. postmenopausal women) of the left mOFC functional connectivity. Credit:Aging(2024). DOI: 10.18632/aging.205662A

Updated on:April 06,2024

How astrocytes and perineuronal nets cooperate to sustain synaptic homeostasis

by Ingrid Fadelli , Medical XpressConfocal micrographs showing close association between Perineuronal nets (magenta) and astrocytes (green) in mouse cerebral cortex. Credit: Bhanu TewariSynapses are s

Updated on: August 08,2024

How astrocytes and perineuronal nets cooperate to sustain synaptic homeostasis

by Ingrid Fadelli , Medical XpressConfocal micrographs showing close association between Perineuronal nets (magenta) and astrocytes (green) in mouse cerebral cortex. Credit: Bhanu TewariSynapses are s

Updated on:August 08,2024

Activity is important for your brain and for the prevention of Alzheimer's, suggests neurovascular study

by University of Copenhagen"By staying active, we are able to maintain a healthy vascular system so that the blood vessels stay flexible and retain the ability to drive forward the cerebrosp

Updated on: March 02,2024

Activity is important for your brain and for the prevention of Alzheimer's, suggests neurovascular study

by University of Copenhagen"By staying active, we are able to maintain a healthy vascular system so that the blood vessels stay flexible and retain the ability to drive forward the cerebrosp

Updated on:March 02,2024