New gene therapy for metachromatic leukodystrophy proves effective in mice

by Marie Simon, Paris Brain InstituteGraphical abstract. Credit: Molecular Therapy - Methods & Clinical Development (2024). DOI: 10.1016/j.omtm.2024.101248Metachromatic leukodystrophy is a rare ge

Updated on: May 14,2024 0

New gene therapy for metachromatic leukodystrophy proves effective in mice

by Marie Simon, Paris Brain InstituteGraphical abstract. Credit: Molecular Therapy - Methods & Clinical Development (2024). DOI: 10.1016/j.omtm.2024.101248Metachromatic leukodystrophy is a rare ge

Updated on:May 14,2024 0

Brains with compromised 'trust settings' a warning sign of lurking depression

byHiroshima UniversityCredit: Andrea Piacquadio/PexelsJust as computer devices acting differently can hint at the possibility of malware lurking in the background, changes in brain patterns that

Updated on: January 21,2024 18

Brains with compromised 'trust settings' a warning sign of lurking depression

byHiroshima UniversityCredit: Andrea Piacquadio/PexelsJust as computer devices acting differently can hint at the possibility of malware lurking in the background, changes in brain patterns that

Updated on:January 21,2024 18

Some antidepressants take weeks to kick in, and scientists may now know why

by Cara MurezMost folks know that certain antidepressants have to be taken for a few weeks before people start seeing improvement, and now a new study sheds light on that delay.Scientists have discove

Updated on: January 11,2024 18

Some antidepressants take weeks to kick in, and scientists may now know why

by Cara MurezMost folks know that certain antidepressants have to be taken for a few weeks before people start seeing improvement, and now a new study sheds light on that delay.Scientists have discove

Updated on:January 11,2024 18

Stem cell treatment for dementia clears major hurdle

by University of California, Los AngelesCredit: CC0 Public DomainA new stem cell-based treatment for progressive dementia just took a big step closer to the clinic.UCLA researchers have successfu

Updated on: June 04,2024 6

Stem cell treatment for dementia clears major hurdle

by University of California, Los AngelesCredit: CC0 Public DomainA new stem cell-based treatment for progressive dementia just took a big step closer to the clinic.UCLA researchers have successfu

Updated on:June 04,2024 6

Researchers unveil vital role of astrocytes in mental health

by Liu Jia, Chinese Academy of SciencesCredit: Neuron (2024). DOI: 10.1016/j.neuron.2024.03.028Astrocytes, as vital cells in the central nervous system, are crucial for brain health and function. Rece

Updated on: May 14,2024 0

Researchers unveil vital role of astrocytes in mental health

by Liu Jia, Chinese Academy of SciencesCredit: Neuron (2024). DOI: 10.1016/j.neuron.2024.03.028Astrocytes, as vital cells in the central nervous system, are crucial for brain health and function. Rece

Updated on:May 14,2024 0

Pathway discovered that prevents buildup of Alzheimer's protein

by St. Jude Children's Research HospitalFirst author Bradlee Heckmann, Ph.D. (right), a postdoctoral fellow in Doug Green's (left) laboratory at St. Jude, led research that identified the

Updated on: May 28,2024 3

Pathway discovered that prevents buildup of Alzheimer's protein

by St. Jude Children's Research HospitalFirst author Bradlee Heckmann, Ph.D. (right), a postdoctoral fellow in Doug Green's (left) laboratory at St. Jude, led research that identified the

Updated on:May 28,2024 3

How dopaminergic systems in fruit flies create reward-seeking behaviors despite adverse consequences

by Bob Yirka , Medical XpressReward DAN activity reduces subsequent need seeking. a, Left, schematics and experimental protocol. Right, starved flies trained with 0273-neuron activation (orange) disre

Updated on: January 11,2024 16

How dopaminergic systems in fruit flies create reward-seeking behaviors despite adverse consequences

by Bob Yirka , Medical XpressReward DAN activity reduces subsequent need seeking. a, Left, schematics and experimental protocol. Right, starved flies trained with 0273-neuron activation (orange) disre

Updated on:January 11,2024 16

Cell engineering team links cancer drug to potential therapy for Alzheimer's disease

FEBRUARY 23, 2024byJohns Hopkins UniversityNeurons that express Lag3 proteins (grey/white) can take in Tau proteins (red) compared with neighboring neurons that do not express Lag3. Credit: Xiao

Updated on: March 25,2024 11

Cell engineering team links cancer drug to potential therapy for Alzheimer's disease

FEBRUARY 23, 2024byJohns Hopkins UniversityNeurons that express Lag3 proteins (grey/white) can take in Tau proteins (red) compared with neighboring neurons that do not express Lag3. Credit: Xiao

Updated on:March 25,2024 11

Finding flicker's therapeutic pathway, opening the door to non-invasive treatments for neurodegenerative diseases

by Jerry Grillo,Georgia Institute of TechnologyProposed mechanisms by which 40 Hz flicker changes microglia and cytokine signaling. Credit:Science Advances(2023). DOI: 10.1126/sciadv

Updated on: May 28,2024 7

Finding flicker's therapeutic pathway, opening the door to non-invasive treatments for neurodegenerative diseases

by Jerry Grillo,Georgia Institute of TechnologyProposed mechanisms by which 40 Hz flicker changes microglia and cytokine signaling. Credit:Science Advances(2023). DOI: 10.1126/sciadv

Updated on:May 28,2024 7

Older class of type 2 diabetes drugs, glitazones, linked to 22% reduction in dementia risk

by British Medical JournalCredit: Pixabay/CC0 Public DomainUse of an older class of type 2 diabetes drugs called glitazones, also known as thiazolidinediones or TZDs for short, is linked to a 22%

Updated on: June 24,2024 7

Older class of type 2 diabetes drugs, glitazones, linked to 22% reduction in dementia risk

by British Medical JournalCredit: Pixabay/CC0 Public DomainUse of an older class of type 2 diabetes drugs called glitazones, also known as thiazolidinediones or TZDs for short, is linked to a 22%

Updated on:June 24,2024 7

Physical fitness since childhood associated with cerebellar volume in adolescence: Study

byUniversity of Eastern FinlandPhysical fitness since childhood predicts cerebellar volume in adolescence. Credit: Petri JalankoPhysical fitness since childhood is associated with cerebellar gra

Updated on: January 10,2024 10

Physical fitness since childhood associated with cerebellar volume in adolescence: Study

byUniversity of Eastern FinlandPhysical fitness since childhood predicts cerebellar volume in adolescence. Credit: Petri JalankoPhysical fitness since childhood is associated with cerebellar gra

Updated on:January 10,2024 10

Early signs of Alzheimer's: Most older adults see the value of screening but haven't been tested

by University of MichiganFamiliarity with, and experience with, cognitive testing and Alzheimer's biomarker testing among adults age 65-80. Credit: University of MichiganSome 80% of older adu

Updated on: April 18,2024 19

Early signs of Alzheimer's: Most older adults see the value of screening but haven't been tested

by University of MichiganFamiliarity with, and experience with, cognitive testing and Alzheimer's biomarker testing among adults age 65-80. Credit: University of MichiganSome 80% of older adu

Updated on:April 18,2024 19