Understanding the genetic roots of rare mutations in Alzheimer's disease

byVIB (the Flanders Institute for Biotechnology)Hippocampal neurons with staining for endosomes (turquoise and purple) and lysosomes (yellow). When the PSEN2 gene is absent or carries a familial

Updated on: December 11,2024

Understanding the genetic roots of rare mutations in Alzheimer's disease

byVIB (the Flanders Institute for Biotechnology)Hippocampal neurons with staining for endosomes (turquoise and purple) and lysosomes (yellow). When the PSEN2 gene is absent or carries a familial

Updated on:December 11,2024

Researchers identify 'neurostatin' that may reduce the risk of Alzheimer's disease

by University of CambridgeDiagram of the brain of a person with Alzheimer's Disease. Credit: Wikipedia/public domain.Researchers have identified a drug that targets the first step in the toxi

Updated on: February 28,2024

Researchers identify 'neurostatin' that may reduce the risk of Alzheimer's disease

by University of CambridgeDiagram of the brain of a person with Alzheimer's Disease. Credit: Wikipedia/public domain.Researchers have identified a drug that targets the first step in the toxi

Updated on:February 28,2024

Alzheimer's: New study supports amyloid hypothesis but suggests alternative treatment

by Columbia UniversityCREB3L2-ATF4 up-regulation in β-amyloid pathology 5xFAD model. In vivo detection and quantification of CREB3L2-ATF4 dimers by PLA in the dentate gyrus of 10-week-old 5xFAD o

Updated on: April 10,2024

Alzheimer's: New study supports amyloid hypothesis but suggests alternative treatment

by Columbia UniversityCREB3L2-ATF4 up-regulation in β-amyloid pathology 5xFAD model. In vivo detection and quantification of CREB3L2-ATF4 dimers by PLA in the dentate gyrus of 10-week-old 5xFAD o

Updated on:April 10,2024

Immune system dysfunction may occur early in Alzheimer's disease

by CU Anschutz Medical CampusPET scan of a human brain with Alzheimer's disease. Credit: public domainAn association between inflammation biomarkers in both blood plasma and cerebrospinal flu

Updated on: April 16,2024

Immune system dysfunction may occur early in Alzheimer's disease

by CU Anschutz Medical CampusPET scan of a human brain with Alzheimer's disease. Credit: public domainAn association between inflammation biomarkers in both blood plasma and cerebrospinal flu

Updated on:April 16,2024

Study finds tumor growth fueled by nucleotide salvage

byUTSouthwestern Medical CenterGraphical abstract. Credit:Cell(2024). DOI: 10.1016/j.cell.2024.05.011Cancer cells salvage purine nucleotides to fuel tumor growth, including pur

Updated on: August 01,2024

Study finds tumor growth fueled by nucleotide salvage

byUTSouthwestern Medical CenterGraphical abstract. Credit:Cell(2024). DOI: 10.1016/j.cell.2024.05.011Cancer cells salvage purine nucleotides to fuel tumor growth, including pur

Updated on:August 01,2024

Cardiometabolic diseases may influence both risk and progression of motor neuron diseases

Cardiometabolic diseases may influence both risk and progression of motor neuron diseasesbyKarolinska InstitutetCredit: PixabayA new study from the Institute of Environmental Medicine (IMM),&nbs

Updated on: January 15,2025

Cardiometabolic diseases may influence both risk and progression of motor neuron diseases

Cardiometabolic diseases may influence both risk and progression of motor neuron diseasesbyKarolinska InstitutetCredit: PixabayA new study from the Institute of Environmental Medicine (IMM),&nbs

Updated on:January 15,2025

Combining cell therapy with approved drug shows promise for treating multiple sclerosis

byJosep Carreras Leukaemia Research InstituteCredit: Pixabay/CC0 Public DomainMultiple sclerosis (MS) is a long-term disease where the immune system mistakenly attacks the protective layer aroun

Updated on: October 14,2024

Combining cell therapy with approved drug shows promise for treating multiple sclerosis

byJosep Carreras Leukaemia Research InstituteCredit: Pixabay/CC0 Public DomainMultiple sclerosis (MS) is a long-term disease where the immune system mistakenly attacks the protective layer aroun

Updated on:October 14,2024

Decoding sleep to reveal our state of health

by Bruno Geoffroy,University of MontrealA Schematic representation of the position of cannulas (in CA1) and electrodes (surface of the cerebral cortex) and timeline of the experimental protocol.

Updated on: March 28,2024

Decoding sleep to reveal our state of health

by Bruno Geoffroy,University of MontrealA Schematic representation of the position of cannulas (in CA1) and electrodes (surface of the cerebral cortex) and timeline of the experimental protocol.

Updated on:March 28,2024

Does fungus cause Alzheimer's?

Diagram of the brain of a person with Alzheimer's Disease. Credit: Wikipedia/public domain.Traces of fungus have been discovered in the brains of Alzheimer's sufferers, researchers said Thursd

Updated on: February 26,2024

Does fungus cause Alzheimer's?

Diagram of the brain of a person with Alzheimer's Disease. Credit: Wikipedia/public domain.Traces of fungus have been discovered in the brains of Alzheimer's sufferers, researchers said Thursd

Updated on:February 26,2024

Faults in the blood-brain barrier implicated in dementia

by Alzheimer's Research UKCalifornia based researchers have found that damage to cells known as pericytes, which surround small blood vessels in the brain, may trigger a chain of events that

Updated on: March 07,2024

Faults in the blood-brain barrier implicated in dementia

by Alzheimer's Research UKCalifornia based researchers have found that damage to cells known as pericytes, which surround small blood vessels in the brain, may trigger a chain of events that

Updated on:March 07,2024

P-glycoprotein removes Alzheimer's-associated toxin from the brain

by Southern Methodist University(A) The first frame of SMU's simulation shows amyloid-β bound to the drug binding domains of P-gp. (B) The final frame of the same simulation shows P-gp pushin

Updated on: April 01,2024

P-glycoprotein removes Alzheimer's-associated toxin from the brain

by Southern Methodist University(A) The first frame of SMU's simulation shows amyloid-β bound to the drug binding domains of P-gp. (B) The final frame of the same simulation shows P-gp pushin

Updated on:April 01,2024

Investigating plasma levels as a biomarker for Alzheimer's disease

by Bentham Science PublishersA Centre for Healthy Brain Ageing (CHeBA) paper published inCurrent Alzheimer Researchpresents the first detailed study of the relationship between plasma leve

Updated on: February 28,2024

Investigating plasma levels as a biomarker for Alzheimer's disease

by Bentham Science PublishersA Centre for Healthy Brain Ageing (CHeBA) paper published inCurrent Alzheimer Researchpresents the first detailed study of the relationship between plasma leve

Updated on:February 28,2024