Structural analysis of relevant drug targets for Alzheimer's disease

by Bentham Science PublishersAlzheimer's Disease (AD) is classified as a neurodegenerative non-curable disease that affects millions worldwide. Current drugs have side effects that are significant

Updated on: March 07,2024

Structural analysis of relevant drug targets for Alzheimer's disease

by Bentham Science PublishersAlzheimer's Disease (AD) is classified as a neurodegenerative non-curable disease that affects millions worldwide. Current drugs have side effects that are significant

Updated on:March 07,2024

Ultra-processed foods—like cookies, chips, frozen meals and fast food—may contribute to cognitive decline

by Sara N. Burke,The ConversationCredit: Unsplash/CC0 Public DomainScientists have known for years that unhealthy diets—particularly those that are high in fat and sugar—may causedetriment

Updated on: February 05,2024

Ultra-processed foods—like cookies, chips, frozen meals and fast food—may contribute to cognitive decline

by Sara N. Burke,The ConversationCredit: Unsplash/CC0 Public DomainScientists have known for years that unhealthy diets—particularly those that are high in fat and sugar—may causedetriment

Updated on:February 05,2024

Certain genetic variant in Alzheimer's disease linked to African ancestry

by Elana GotkineFor individuals of African ancestry, theAPOEε3 R145C missense variant is associated with an increased risk for Alzheimer disease (AD), according to a study published in the

Updated on: April 25,2024

Certain genetic variant in Alzheimer's disease linked to African ancestry

by Elana GotkineFor individuals of African ancestry, theAPOEε3 R145C missense variant is associated with an increased risk for Alzheimer disease (AD), according to a study published in the

Updated on:April 25,2024

Unraveling the neural circuit behind reduced food intake in high temperatures

byKarolinska InstitutetAcute heat reduces food intake and selectively activates α-tanycytes. Credit:Nature(2024). DOI: 10.1038/s41586-024-07232-3In a study recentlypublished&nb

Updated on: April 28,2024

Unraveling the neural circuit behind reduced food intake in high temperatures

byKarolinska InstitutetAcute heat reduces food intake and selectively activates α-tanycytes. Credit:Nature(2024). DOI: 10.1038/s41586-024-07232-3In a study recentlypublished&nb

Updated on:April 28,2024

Researchers show multiple sclerosis drug can be used as Alzheimer's therapy

by Lindsay Travis,University of KentuckyWorking model for the effect of ponesimod on microglial activation and phagocytosis. Aβ42 binds to TLR4 and induces a complex with S1PR1. S1P co-activates

Updated on: March 02,2024

Researchers show multiple sclerosis drug can be used as Alzheimer's therapy

by Lindsay Travis,University of KentuckyWorking model for the effect of ponesimod on microglial activation and phagocytosis. Aβ42 binds to TLR4 and induces a complex with S1PR1. S1P co-activates

Updated on:March 02,2024

Opinion: New Alzheimer's drugs don't deserve the hype—here's why

by Sebastian Walsh,The ConversationCredit: AI-generated imageA prominent childhood memory is of my grandparents living with and then dying from dementia. As is universal with dementia, there was

Updated on: March 02,2024

Opinion: New Alzheimer's drugs don't deserve the hype—here's why

by Sebastian Walsh,The ConversationCredit: AI-generated imageA prominent childhood memory is of my grandparents living with and then dying from dementia. As is universal with dementia, there was

Updated on:March 02,2024

Study shows activity of claustrum neurons controls alertness level, engagement of sensory information

byHebrew University of JerusalemApproach for hM3Dq DREADD experiments (left) and setup (right). Credit:Nature Communications(2024). DOI: 10.1038/s41467-024-48829-6A new study has unc

Updated on: July 08,2024

Study shows activity of claustrum neurons controls alertness level, engagement of sensory information

byHebrew University of JerusalemApproach for hM3Dq DREADD experiments (left) and setup (right). Credit:Nature Communications(2024). DOI: 10.1038/s41467-024-48829-6A new study has unc

Updated on:July 08,2024

Alzheimer's drug trial targets toxic proteases from gum disease bacteria in the brain

by Alzheimer's Research UKP. gingivalis colonies grown on blood agar. CC0 Public DomainThe pharmaceutical company, Cortexyme, Inc. has outlined a trial of potential Alzheimer's drug that

Updated on: April 16,2024

Alzheimer's drug trial targets toxic proteases from gum disease bacteria in the brain

by Alzheimer's Research UKP. gingivalis colonies grown on blood agar. CC0 Public DomainThe pharmaceutical company, Cortexyme, Inc. has outlined a trial of potential Alzheimer's drug that

Updated on:April 16,2024

Insulin signaling failures in the brain linked to Alzheimer's disease

by Joslin Diabetes CenterC. Ronald Kahn, Chief Academic Officer at Joslin Diabetes Center, and Mary K. Iacocca Professor of Medicine at Harvard Medical School Credit: Joslin CommunicationsScienti

Updated on: May 18,2024

Insulin signaling failures in the brain linked to Alzheimer's disease

by Joslin Diabetes CenterC. Ronald Kahn, Chief Academic Officer at Joslin Diabetes Center, and Mary K. Iacocca Professor of Medicine at Harvard Medical School Credit: Joslin CommunicationsScienti

Updated on:May 18,2024

Detecting Alzheimer's disease in the blood

by Hokkaido UniversityConcept for digital detection of amyloid β-binding exosomes in the blood of an Alzheimer's disease model mouse. Credit: Kohei YuyamaResearchers from Hokkaido University

Updated on: June 20,2024

Detecting Alzheimer's disease in the blood

by Hokkaido UniversityConcept for digital detection of amyloid β-binding exosomes in the blood of an Alzheimer's disease model mouse. Credit: Kohei YuyamaResearchers from Hokkaido University

Updated on:June 20,2024

Tau-based biomarker tracks Alzheimer's progression

by Washington University School of MedicineKanta Horie, PhD, works with a mass spectrometer that he uses to measure protein levels in cerebrospinal fluid samples. Horie and colleagues at Washingt

Updated on: June 18,2024

Tau-based biomarker tracks Alzheimer's progression

by Washington University School of MedicineKanta Horie, PhD, works with a mass spectrometer that he uses to measure protein levels in cerebrospinal fluid samples. Horie and colleagues at Washingt

Updated on:June 18,2024

Curry spice holds clues to Alzheimer's drug targets

by Alzheimer's Research UKCalifornian researchers have shed more light on the action of an experimental Alzheimer's drug based on a modified component of the curry spice turmeric. The res

Updated on: March 07,2024

Curry spice holds clues to Alzheimer's drug targets

by Alzheimer's Research UKCalifornian researchers have shed more light on the action of an experimental Alzheimer's drug based on a modified component of the curry spice turmeric. The res

Updated on:March 07,2024