Mitochondrial roles in antiviral immunity modify manifestations of neurological diseases

by University of HelsinkiSchematic of antiviral innate immune signaling responses to viral PAMPs. Credit:Nature(2024). DOI: 10.1038/s41586-024-07260-zA multidisciplinary team of scien

Updated on: April 06,2024

Mitochondrial roles in antiviral immunity modify manifestations of neurological diseases

by University of HelsinkiSchematic of antiviral innate immune signaling responses to viral PAMPs. Credit:Nature(2024). DOI: 10.1038/s41586-024-07260-zA multidisciplinary team of scien

Updated on:April 06,2024

How are 'super agers' protected from Alzheimer's and mental decline?

by Alan Mozes Healthday Reporter(HealthDay)—Some older folks are still sharp as tacks and dementia-free well into their 80s and beyond. Now German researchers have uncovered a possible reason why: The

Updated on: March 13,2024

How are 'super agers' protected from Alzheimer's and mental decline?

by Alan Mozes Healthday Reporter(HealthDay)—Some older folks are still sharp as tacks and dementia-free well into their 80s and beyond. Now German researchers have uncovered a possible reason why: The

Updated on:March 13,2024

How humans continuously adapt while walking stably

byMassachusetts Institute of TechnologyA hierarchical framework for locomotor adaptation. Credit:Nature Communications(2024). DOI: 10.1038/s41467-024-53416-wResearchers have develope

Updated on: January 15,2025

How humans continuously adapt while walking stably

byMassachusetts Institute of TechnologyA hierarchical framework for locomotor adaptation. Credit:Nature Communications(2024). DOI: 10.1038/s41467-024-53416-wResearchers have develope

Updated on:January 15,2025

How antidepressants, ketamine and psychedelic drugs may make brains more flexible—new research

by Barbara Jacquelyn Sahakian and Christelle Langley,The ConversationCredit: Juan Gaertner/ShutterstockThe first-line pharmacological treatment for major depressive disorder (MDD) are antidepres

Updated on: January 12,2024

How antidepressants, ketamine and psychedelic drugs may make brains more flexible—new research

by Barbara Jacquelyn Sahakian and Christelle Langley,The ConversationCredit: Juan Gaertner/ShutterstockThe first-line pharmacological treatment for major depressive disorder (MDD) are antidepres

Updated on:January 12,2024

Machine learning gives nuanced view of Alzheimer's stages

by David Nutt,Cornell UniversityFeed-forward, fully-connected neural network architecture. Nonlinear models have rectified linear units (ReLU) between layers. Final layer implements a soft-max.

Updated on: June 14,2024

Machine learning gives nuanced view of Alzheimer's stages

by David Nutt,Cornell UniversityFeed-forward, fully-connected neural network architecture. Nonlinear models have rectified linear units (ReLU) between layers. Final layer implements a soft-max.

Updated on:June 14,2024

New visual technique could advance early detection of neurodegenerative diseases

byUniversity of MinnesotaIntroduction and overview of Cap-QuIC method. Credit:npj Biosensing(2024). DOI: 10.1038/s44328-024-00003-0Researchers at the University of Minnesota have dev

Updated on: August 08,2024

New visual technique could advance early detection of neurodegenerative diseases

byUniversity of MinnesotaIntroduction and overview of Cap-QuIC method. Credit:npj Biosensing(2024). DOI: 10.1038/s44328-024-00003-0Researchers at the University of Minnesota have dev

Updated on:August 08,2024

Researchers show multiple sclerosis drug can be used as Alzheimer's therapy

by Lindsay Travis,University of KentuckyWorking model for the effect of ponesimod on microglial activation and phagocytosis. Aβ42 binds to TLR4 and induces a complex with S1PR1. S1P co-activates

Updated on: March 02,2024

Researchers show multiple sclerosis drug can be used as Alzheimer's therapy

by Lindsay Travis,University of KentuckyWorking model for the effect of ponesimod on microglial activation and phagocytosis. Aβ42 binds to TLR4 and induces a complex with S1PR1. S1P co-activates

Updated on:March 02,2024

From Alzheimer's to autism, nuclear neurology could launch revolution in diagnosing and treating brain diseases

by Ellen Goldbaum,University at BuffaloImage of glucose metabolism PET overlaid on CT in an Alzheimer's patient with mild dementia. Green arrow points to regional hypometabolism in the media

Updated on: May 13,2024

From Alzheimer's to autism, nuclear neurology could launch revolution in diagnosing and treating brain diseases

by Ellen Goldbaum,University at BuffaloImage of glucose metabolism PET overlaid on CT in an Alzheimer's patient with mild dementia. Green arrow points to regional hypometabolism in the media

Updated on:May 13,2024

Poor gut health may drive multiple sclerosis—better diet may ease it

by Rutgers UniversityDevelopment of colitis in spontaneous EAE mice. (A) Swollen colon in spontaneous EAE mice. (B) H&E histopathology of swollen colon isolated from spontaneous EAE and non-E

Updated on: February 03,2024

Poor gut health may drive multiple sclerosis—better diet may ease it

by Rutgers UniversityDevelopment of colitis in spontaneous EAE mice. (A) Swollen colon in spontaneous EAE mice. (B) H&E histopathology of swollen colon isolated from spontaneous EAE and non-E

Updated on:February 03,2024

Build-up of brain proteins affects genes in Alzheimer's disease

by University of ExeterImage of tau build-up in mouse brain. At two months. Credit: University of ExeterNew research has shed fresh light on how the build-up of two proteins in the brain might af

Updated on: May 18,2024

Build-up of brain proteins affects genes in Alzheimer's disease

by University of ExeterImage of tau build-up in mouse brain. At two months. Credit: University of ExeterNew research has shed fresh light on how the build-up of two proteins in the brain might af

Updated on:May 18,2024

The molecular mechanisms of Alzheimer's

by Pacific Northwest National LaboratoryFigure 1 in the paper outlines the quantitative proteomic pipeline for O-GlcNAc analysis. stochastic kinetic simulations (red) and simulations using the co

Updated on: April 07,2024

The molecular mechanisms of Alzheimer's

by Pacific Northwest National LaboratoryFigure 1 in the paper outlines the quantitative proteomic pipeline for O-GlcNAc analysis. stochastic kinetic simulations (red) and simulations using the co

Updated on:April 07,2024

CRISPR helps identify potential Alzheimer's-related protein

by University of TokyoCredit: CC0 Public DomainExperts at the University of Tokyo have identified a new protein in the pathway that leads to Alzheimer's disease. Researchers used the "mo

Updated on: March 30,2024

CRISPR helps identify potential Alzheimer's-related protein

by University of TokyoCredit: CC0 Public DomainExperts at the University of Tokyo have identified a new protein in the pathway that leads to Alzheimer's disease. Researchers used the "mo

Updated on:March 30,2024