Researchers show multiple sclerosis drug can be used as Alzheimer's therapy

by Lindsay Travis,University of KentuckyWorking model for the effect of ponesimod on microglial activation and phagocytosis. Aβ42 binds to TLR4 and induces a complex with S1PR1. S1P co-activates

Updated on: March 02,2024

Researchers show multiple sclerosis drug can be used as Alzheimer's therapy

by Lindsay Travis,University of KentuckyWorking model for the effect of ponesimod on microglial activation and phagocytosis. Aβ42 binds to TLR4 and induces a complex with S1PR1. S1P co-activates

Updated on:March 02,2024

How humans continuously adapt while walking stably

byMassachusetts Institute of TechnologyA hierarchical framework for locomotor adaptation. Credit:Nature Communications(2024). DOI: 10.1038/s41467-024-53416-wResearchers have develope

Updated on: January 15,2025

How humans continuously adapt while walking stably

byMassachusetts Institute of TechnologyA hierarchical framework for locomotor adaptation. Credit:Nature Communications(2024). DOI: 10.1038/s41467-024-53416-wResearchers have develope

Updated on:January 15,2025

Scientists isolate genes that delay Alzheimer's

by Australian National UniversityAssociate Professor Arcos-Burgos (centre) with Dr Claudio Mastronardi and Dr Hardip Patel. Credit: Stuart Hay, ANUScientists have identified a network of nine gen

Updated on: February 27,2024

Scientists isolate genes that delay Alzheimer's

by Australian National UniversityAssociate Professor Arcos-Burgos (centre) with Dr Claudio Mastronardi and Dr Hardip Patel. Credit: Stuart Hay, ANUScientists have identified a network of nine gen

Updated on:February 27,2024

From Alzheimer's to autism, nuclear neurology could launch revolution in diagnosing and treating brain diseases

by Ellen Goldbaum,University at BuffaloImage of glucose metabolism PET overlaid on CT in an Alzheimer's patient with mild dementia. Green arrow points to regional hypometabolism in the media

Updated on: May 13,2024

From Alzheimer's to autism, nuclear neurology could launch revolution in diagnosing and treating brain diseases

by Ellen Goldbaum,University at BuffaloImage of glucose metabolism PET overlaid on CT in an Alzheimer's patient with mild dementia. Green arrow points to regional hypometabolism in the media

Updated on:May 13,2024

Machine learning gives nuanced view of Alzheimer's stages

by David Nutt,Cornell UniversityFeed-forward, fully-connected neural network architecture. Nonlinear models have rectified linear units (ReLU) between layers. Final layer implements a soft-max.

Updated on: June 14,2024

Machine learning gives nuanced view of Alzheimer's stages

by David Nutt,Cornell UniversityFeed-forward, fully-connected neural network architecture. Nonlinear models have rectified linear units (ReLU) between layers. Final layer implements a soft-max.

Updated on:June 14,2024

Couch potatoes face same chance of dementia as those with genetic risk factors

by McMaster UniversityJennifer Heisz, assistant professor of kinesiology, McMaster University Credit: McMaster UniversitySedentary older adults with no genetic risk factors for dementia may be ju

Updated on: March 09,2024

Couch potatoes face same chance of dementia as those with genetic risk factors

by McMaster UniversityJennifer Heisz, assistant professor of kinesiology, McMaster University Credit: McMaster UniversitySedentary older adults with no genetic risk factors for dementia may be ju

Updated on:March 09,2024

Poor gut health may drive multiple sclerosis—better diet may ease it

by Rutgers UniversityDevelopment of colitis in spontaneous EAE mice. (A) Swollen colon in spontaneous EAE mice. (B) H&E histopathology of swollen colon isolated from spontaneous EAE and non-E

Updated on: February 03,2024

Poor gut health may drive multiple sclerosis—better diet may ease it

by Rutgers UniversityDevelopment of colitis in spontaneous EAE mice. (A) Swollen colon in spontaneous EAE mice. (B) H&E histopathology of swollen colon isolated from spontaneous EAE and non-E

Updated on:February 03,2024

Opioid analgesics increase the risk of pneumonia among persons with Alzheimer's disease

by University of Eastern FinlandCredit: CC0 Public DomainOpioid analgesics were associated with a 30 percent increase in the risk of pneumonia in persons with Alzheimer's disease, a recent st

Updated on: April 25,2024

Opioid analgesics increase the risk of pneumonia among persons with Alzheimer's disease

by University of Eastern FinlandCredit: CC0 Public DomainOpioid analgesics were associated with a 30 percent increase in the risk of pneumonia in persons with Alzheimer's disease, a recent st

Updated on:April 25,2024

The molecular mechanisms of Alzheimer's

by Pacific Northwest National LaboratoryFigure 1 in the paper outlines the quantitative proteomic pipeline for O-GlcNAc analysis. stochastic kinetic simulations (red) and simulations using the co

Updated on: April 07,2024

The molecular mechanisms of Alzheimer's

by Pacific Northwest National LaboratoryFigure 1 in the paper outlines the quantitative proteomic pipeline for O-GlcNAc analysis. stochastic kinetic simulations (red) and simulations using the co

Updated on:April 07,2024

New visual technique could advance early detection of neurodegenerative diseases

byUniversity of MinnesotaIntroduction and overview of Cap-QuIC method. Credit:npj Biosensing(2024). DOI: 10.1038/s44328-024-00003-0Researchers at the University of Minnesota have dev

Updated on: August 08,2024

New visual technique could advance early detection of neurodegenerative diseases

byUniversity of MinnesotaIntroduction and overview of Cap-QuIC method. Credit:npj Biosensing(2024). DOI: 10.1038/s44328-024-00003-0Researchers at the University of Minnesota have dev

Updated on:August 08,2024

Build-up of brain proteins affects genes in Alzheimer's disease

by University of ExeterImage of tau build-up in mouse brain. At two months. Credit: University of ExeterNew research has shed fresh light on how the build-up of two proteins in the brain might af

Updated on: May 18,2024

Build-up of brain proteins affects genes in Alzheimer's disease

by University of ExeterImage of tau build-up in mouse brain. At two months. Credit: University of ExeterNew research has shed fresh light on how the build-up of two proteins in the brain might af

Updated on:May 18,2024

CRISPR helps identify potential Alzheimer's-related protein

by University of TokyoCredit: CC0 Public DomainExperts at the University of Tokyo have identified a new protein in the pathway that leads to Alzheimer's disease. Researchers used the "mo

Updated on: March 30,2024

CRISPR helps identify potential Alzheimer's-related protein

by University of TokyoCredit: CC0 Public DomainExperts at the University of Tokyo have identified a new protein in the pathway that leads to Alzheimer's disease. Researchers used the "mo

Updated on:March 30,2024