A 'low dose aspirin' for dementia? Drug ready for first in-human testing

by University of KentuckyLinda Van Eldik in her lab at the Sanders-Brown Center on Aging. Van Eldik's drug candidate, which might function as a sort of "low-dose aspirin" for the pr

Updated on: March 13,2024

A 'low dose aspirin' for dementia? Drug ready for first in-human testing

by University of KentuckyLinda Van Eldik in her lab at the Sanders-Brown Center on Aging. Van Eldik's drug candidate, which might function as a sort of "low-dose aspirin" for the pr

Updated on:March 13,2024

A promising discovery in a rare neurodegenerative disease

by Katherine Gombay,McGill UniversityGene expression changes in SCA6 cerebellum at disease onset. (a) Timeline of disease progression in SCA6 mouse model. (b) Cerebellar vermis tissue was extrac

Updated on: March 30,2024

A promising discovery in a rare neurodegenerative disease

by Katherine Gombay,McGill UniversityGene expression changes in SCA6 cerebellum at disease onset. (a) Timeline of disease progression in SCA6 mouse model. (b) Cerebellar vermis tissue was extrac

Updated on:March 30,2024

Discovery adds context to Alzheimer's fight

by Paul Mayne,University of Western OntarioRobarts Research Institute scientists Vania and Marco Prado have found a gene, TRPM2, that could be a therapeutic target to assist in decreasing cognit

Updated on: February 27,2024

Discovery adds context to Alzheimer's fight

by Paul Mayne,University of Western OntarioRobarts Research Institute scientists Vania and Marco Prado have found a gene, TRPM2, that could be a therapeutic target to assist in decreasing cognit

Updated on:February 27,2024

Alzheimer's risk gene impairs development of new neurons in mice

by Society for NeuroscienceApoE-expressing astrocytes (green) interacting with tdTomato-expressing dendrites (red) from adult newborn hippocampal neurons. Credit: Tensaouti et al.,eNeuro&nb

Updated on: April 20,2024

Alzheimer's risk gene impairs development of new neurons in mice

by Society for NeuroscienceApoE-expressing astrocytes (green) interacting with tdTomato-expressing dendrites (red) from adult newborn hippocampal neurons. Credit: Tensaouti et al.,eNeuro&nb

Updated on:April 20,2024

Allopurinol may cut risk for neurodegenerative diseases

by Elana GotkineXanthine dehydrogenase/oxidase blockers may reduce the risk for neurodegenerative diseases, according to a study published online May 17 inPLOS ONE.Yizhe Song, from the Washingto

Updated on: February 05,2024

Allopurinol may cut risk for neurodegenerative diseases

by Elana GotkineXanthine dehydrogenase/oxidase blockers may reduce the risk for neurodegenerative diseases, according to a study published online May 17 inPLOS ONE.Yizhe Song, from the Washingto

Updated on:February 05,2024

New neurons form in the brain into the tenth decade of life, even in people with Alzheimer's

by Jacqueline Carey,University of Illinois at ChicagoNew neurons continue to be formed in the hippocampus into the tenth decade of life, even in people with mild cognitive impairment and Alzheim

Updated on: June 18,2024

New neurons form in the brain into the tenth decade of life, even in people with Alzheimer's

by Jacqueline Carey,University of Illinois at ChicagoNew neurons continue to be formed in the hippocampus into the tenth decade of life, even in people with mild cognitive impairment and Alzheim

Updated on:June 18,2024

Alzheimer's disease can be diagnosed before symptoms emerge

by Lund UniversityNIA-AA versus IWG criteria. Differences in the nomenclature of cognitively unimpaired individuals with (+) or without (−) in vivo biomarker evidence of Aβ (A) and tau (T) pathol

Updated on: April 10,2024

Alzheimer's disease can be diagnosed before symptoms emerge

by Lund UniversityNIA-AA versus IWG criteria. Differences in the nomenclature of cognitively unimpaired individuals with (+) or without (−) in vivo biomarker evidence of Aβ (A) and tau (T) pathol

Updated on:April 10,2024

Human brains are getting larger: That may be good news for dementia risk

byUC DavisHuman brain volume has increased for people born in the 1970s compared to the 1930s. Credit: UC Davis HealthA new study by researchers at UC Davis Health found human brains are getting

Updated on: March 28,2024

Human brains are getting larger: That may be good news for dementia risk

byUC DavisHuman brain volume has increased for people born in the 1970s compared to the 1930s. Credit: UC Davis HealthA new study by researchers at UC Davis Health found human brains are getting

Updated on:March 28,2024

LATE: A common but largely unknown cause of dementia

by Andrew E. Budson,Harvard UniversityCredit: Pixabay/CC0 Public DomainIf dementia is a general term that means thinking and memory has deteriorated to the point that it interferes with day-to-d

Updated on: May 11,2024

LATE: A common but largely unknown cause of dementia

by Andrew E. Budson,Harvard UniversityCredit: Pixabay/CC0 Public DomainIf dementia is a general term that means thinking and memory has deteriorated to the point that it interferes with day-to-d

Updated on:May 11,2024

Alzheimer's research—intracellular calcium store malfunction leads to brain hyperactivity

by Universitaet TübingenAmyloid proteins (plaques, blue) in the cerebral cortex of a mouse model of Alzheimer’s disease, surrounded by cortical immune cells (microglia, green). Activated microgli

Updated on: April 16,2024

Alzheimer's research—intracellular calcium store malfunction leads to brain hyperactivity

by Universitaet TübingenAmyloid proteins (plaques, blue) in the cerebral cortex of a mouse model of Alzheimer’s disease, surrounded by cortical immune cells (microglia, green). Activated microgli

Updated on:April 16,2024

New imaging method illuminates oxygen's journey in the brain

by University of Rochester Medical CenterLuminescent protein, substrate, and oxygen all combine to create chemical chain reaction to produce light. Images shows the cortex of a mouse recorded ove

Updated on: March 30,2024

New imaging method illuminates oxygen's journey in the brain

by University of Rochester Medical CenterLuminescent protein, substrate, and oxygen all combine to create chemical chain reaction to produce light. Images shows the cortex of a mouse recorded ove

Updated on:March 30,2024

Study investigates how effective multiple sclerosis medications are across racial and ethnic groups

byAmerican Academy of NeurologyCredit: Unsplash/CC0 Public DomainFor people with relapsing-remitting multiple sclerosis (MS), a new study has found that the drug ofatumumab is more effective tha

Updated on: July 31,2024

Study investigates how effective multiple sclerosis medications are across racial and ethnic groups

byAmerican Academy of NeurologyCredit: Unsplash/CC0 Public DomainFor people with relapsing-remitting multiple sclerosis (MS), a new study has found that the drug ofatumumab is more effective tha

Updated on:July 31,2024