Researchers identify the 'broken gate' causing unstoppable brain signals in severe childhood epilepsy

by Florey Institute of Neuroscience and Mental Health2D transmembrane topology of the wild-type (WT) Nav1.2 channel showing 27 domains DI−DIV and amino acid residues N1662 (cytosolic side of S5DIV) an

Updated on: August 03,2024

Researchers identify the 'broken gate' causing unstoppable brain signals in severe childhood epilepsy

by Florey Institute of Neuroscience and Mental Health2D transmembrane topology of the wild-type (WT) Nav1.2 channel showing 27 domains DI−DIV and amino acid residues N1662 (cytosolic side of S5DIV) an

Updated on:August 03,2024

Intranasal insulin may have pro-cognitive benefits

by Elana GotkineIntranasal insulin (INI) seems to have a beneficial effect on global cognition among patients with Alzheimer's disease (AD)/mild cognitive impairment (MCI), according to a review p

Updated on: March 09,2024

Intranasal insulin may have pro-cognitive benefits

by Elana GotkineIntranasal insulin (INI) seems to have a beneficial effect on global cognition among patients with Alzheimer's disease (AD)/mild cognitive impairment (MCI), according to a review p

Updated on:March 09,2024

The role of verb fluency in the detection of early cognitive impairment in Alzheimer's disease

by IOS PressVerb fluency score. Credit: Memory Clinic and Research Center of Fundació ACE, Institut Català de Neurociències Aplicades, Barcelona, SpainThe ability to generate spoken verbs in infi

Updated on: March 09,2024

The role of verb fluency in the detection of early cognitive impairment in Alzheimer's disease

by IOS PressVerb fluency score. Credit: Memory Clinic and Research Center of Fundació ACE, Institut Català de Neurociències Aplicades, Barcelona, SpainThe ability to generate spoken verbs in infi

Updated on:March 09,2024

A healthy lifestyle almost halves the risk of dementia in people with type 2 diabetes

by DiabetologiaCredit: Unsplash/CC0 Public DomainA healthy lifestyle reduces the risk of dementia in those with type 2 diabetes (T2D), according to a study of hundreds of thousands of people in t

Updated on: June 24,2024

A healthy lifestyle almost halves the risk of dementia in people with type 2 diabetes

by DiabetologiaCredit: Unsplash/CC0 Public DomainA healthy lifestyle reduces the risk of dementia in those with type 2 diabetes (T2D), according to a study of hundreds of thousands of people in t

Updated on:June 24,2024

Investigational Alzheimer's drug improves biomarkers of the disease

by Washington University School of MedicineRandall Bateman, MD, director of the Dominantly Inherited Alzheimer Network-Trials Unit (DIAN-TU), an ongoing international clinical trial to evaluate e

Updated on: April 16,2024

Investigational Alzheimer's drug improves biomarkers of the disease

by Washington University School of MedicineRandall Bateman, MD, director of the Dominantly Inherited Alzheimer Network-Trials Unit (DIAN-TU), an ongoing international clinical trial to evaluate e

Updated on:April 16,2024

Navigation skill test could diagnose Alzheimer's long before memory fails

by Gerry Everding,Washington University School of Medicine in St. LouisThe hippocampus (shown in red) is associated with cognitive mapping skills. Credit: Life Science Databases via Wikimedia Co

Updated on: February 28,2024

Navigation skill test could diagnose Alzheimer's long before memory fails

by Gerry Everding,Washington University School of Medicine in St. LouisThe hippocampus (shown in red) is associated with cognitive mapping skills. Credit: Life Science Databases via Wikimedia Co

Updated on:February 28,2024

Alzheimer's research—intracellular calcium store malfunction leads to brain hyperactivity

by Universitaet TübingenAmyloid proteins (plaques, blue) in the cerebral cortex of a mouse model of Alzheimer’s disease, surrounded by cortical immune cells (microglia, green). Activated microgli

Updated on: April 16,2024

Alzheimer's research—intracellular calcium store malfunction leads to brain hyperactivity

by Universitaet TübingenAmyloid proteins (plaques, blue) in the cerebral cortex of a mouse model of Alzheimer’s disease, surrounded by cortical immune cells (microglia, green). Activated microgli

Updated on:April 16,2024

Untangling the role of tau in Alzheimer's disease

by Dani Ellenby, Okinawa Institute of Science and Technology Graduate UniversityWild-type (WT) h-tau loaded in presynaptic terminals inhibited excitatory synaptic transmission. Credit: Tetsuya Hori et

Updated on: July 01,2024

Untangling the role of tau in Alzheimer's disease

by Dani Ellenby, Okinawa Institute of Science and Technology Graduate UniversityWild-type (WT) h-tau loaded in presynaptic terminals inhibited excitatory synaptic transmission. Credit: Tetsuya Hori et

Updated on:July 01,2024

An anti-apoE4 specific monoclonal antibody counteracts the pathological effects of apoE4 in vivo

by Bentham Science PublishersThe pathological hallmarks of Alzheimer's disease (AD), viz defective Aβ and tau proteins, have been the center of AD-directed therapeutic studies. Although this appro

Updated on: March 07,2024

An anti-apoE4 specific monoclonal antibody counteracts the pathological effects of apoE4 in vivo

by Bentham Science PublishersThe pathological hallmarks of Alzheimer's disease (AD), viz defective Aβ and tau proteins, have been the center of AD-directed therapeutic studies. Although this appro

Updated on:March 07,2024

Research highlights misdiagnosis for people with Alzheimer's disease

by Alzheimer's Research UKResearch presented today (Tuesday 26 July) at the Alzheimer's Association International Conference 2016 suggests that men with Alzheimer's may be more likely

Updated on: March 07,2024

Research highlights misdiagnosis for people with Alzheimer's disease

by Alzheimer's Research UKResearch presented today (Tuesday 26 July) at the Alzheimer's Association International Conference 2016 suggests that men with Alzheimer's may be more likely

Updated on:March 07,2024

Alzheimer's detected before symptoms via new eye technology

by Association for Research in Vision and OphthalmologyRockville, Md. Scientists may have overcome a major roadblock in the development of Alzheimer's therapies by creating a new technology t

Updated on: March 07,2024

Alzheimer's detected before symptoms via new eye technology

by Association for Research in Vision and OphthalmologyRockville, Md. Scientists may have overcome a major roadblock in the development of Alzheimer's therapies by creating a new technology t

Updated on:March 07,2024

'Lesser of two evils' argument used to defend antipsychotic overuse for dementia

by University of ReadingCredit: University of ReadingThe increasing use of antipsychotic drugs to manage dementia in care homes has been explained by some practitioners as "the lesser of two

Updated on: March 09,2024

'Lesser of two evils' argument used to defend antipsychotic overuse for dementia

by University of ReadingCredit: University of ReadingThe increasing use of antipsychotic drugs to manage dementia in care homes has been explained by some practitioners as "the lesser of two

Updated on:March 09,2024