Reimagining preclinical trials: Marmosets as model systems for the study of Alzheimer's disease

by University of PittsburghMarmoset models bridge the current translation gap between human studies and cell and rodent models of AD. Establishment of marmoset models of aging and genetic risk lo

Updated on: March 02,2024

Reimagining preclinical trials: Marmosets as model systems for the study of Alzheimer's disease

by University of PittsburghMarmoset models bridge the current translation gap between human studies and cell and rodent models of AD. Establishment of marmoset models of aging and genetic risk lo

Updated on:March 02,2024

Intranasal insulin may have pro-cognitive benefits

by Elana GotkineIntranasal insulin (INI) seems to have a beneficial effect on global cognition among patients with Alzheimer's disease (AD)/mild cognitive impairment (MCI), according to a review p

Updated on: March 09,2024

Intranasal insulin may have pro-cognitive benefits

by Elana GotkineIntranasal insulin (INI) seems to have a beneficial effect on global cognition among patients with Alzheimer's disease (AD)/mild cognitive impairment (MCI), according to a review p

Updated on:March 09,2024

Genetic risk factors for Alzheimer's disease may be detectable even in young adults

by American Academy of NeurologyCredit: CC0 Public DomainNew research shows that a genetic risk score may detect those at higher risk for Alzheimer's disease long before symptoms appear—even

Updated on: April 08,2024

Genetic risk factors for Alzheimer's disease may be detectable even in young adults

by American Academy of NeurologyCredit: CC0 Public DomainNew research shows that a genetic risk score may detect those at higher risk for Alzheimer's disease long before symptoms appear—even

Updated on:April 08,2024

A participatory research project tackling Alzheimer's disease

by Egle Marija Ramanauskaite,Public Library of ScienceCredit: Human Computation Institute CC-BY-NC-SA 4.0, Graphic by PachecoDesignlab.comEarlier this year, weintroducedyou to WeCure

Updated on: February 28,2024

A participatory research project tackling Alzheimer's disease

by Egle Marija Ramanauskaite,Public Library of ScienceCredit: Human Computation Institute CC-BY-NC-SA 4.0, Graphic by PachecoDesignlab.comEarlier this year, weintroducedyou to WeCure

Updated on:February 28,2024

Alzheimer's disease: have we got the cause all wrong?

by Vicky Jones,The ConversationCredit: Unsplash/CC0 Public DomainEarly in the 20th century,Alois Alzheimerfirst described a disorder of progressive memory loss and confusion in a 50-

Updated on: April 10,2024

Alzheimer's disease: have we got the cause all wrong?

by Vicky Jones,The ConversationCredit: Unsplash/CC0 Public DomainEarly in the 20th century,Alois Alzheimerfirst described a disorder of progressive memory loss and confusion in a 50-

Updated on:April 10,2024

Sleep deprivation in mice found to reduce brain synapse diversity

by Bob Yirka , Medical XpressCredit:Current Biology(2024). DOI: 10.1016/j.cub.2024.07.032A multi-disciplinary team has found that depriving lab mice of sleep can lead to a reduction in syn

Updated on: August 08,2024

Sleep deprivation in mice found to reduce brain synapse diversity

by Bob Yirka , Medical XpressCredit:Current Biology(2024). DOI: 10.1016/j.cub.2024.07.032A multi-disciplinary team has found that depriving lab mice of sleep can lead to a reduction in syn

Updated on:August 08,2024

An anti-apoE4 specific monoclonal antibody counteracts the pathological effects of apoE4 in vivo

by Bentham Science PublishersThe pathological hallmarks of Alzheimer's disease (AD), viz defective Aβ and tau proteins, have been the center of AD-directed therapeutic studies. Although this appro

Updated on: March 07,2024

An anti-apoE4 specific monoclonal antibody counteracts the pathological effects of apoE4 in vivo

by Bentham Science PublishersThe pathological hallmarks of Alzheimer's disease (AD), viz defective Aβ and tau proteins, have been the center of AD-directed therapeutic studies. Although this appro

Updated on:March 07,2024

The search for early markers of Alzheimer's Disease

by Ríona Mc Ardle,Public Library of ScienceRegional MRI predictors of MCI-to-dementia progression. Figure courtesy Korolev et al. via PLOS One.This eloquent quote by V.S. Ramachandran expresses

Updated on: February 28,2024

The search for early markers of Alzheimer's Disease

by Ríona Mc Ardle,Public Library of ScienceRegional MRI predictors of MCI-to-dementia progression. Figure courtesy Korolev et al. via PLOS One.This eloquent quote by V.S. Ramachandran expresses

Updated on:February 28,2024

Using tau imaging as diagnostic marker for Alzheimer disease

by The JAMA Network JournalsThe accumulation of β-Amyloid (Αβ) and tau proteins in the brain is hallmark pathology for Alzheimer disease. Recently developed positron emission tomography (PET) tra

Updated on: March 07,2024

Using tau imaging as diagnostic marker for Alzheimer disease

by The JAMA Network JournalsThe accumulation of β-Amyloid (Αβ) and tau proteins in the brain is hallmark pathology for Alzheimer disease. Recently developed positron emission tomography (PET) tra

Updated on:March 07,2024

Control of the iRhom2 protein may hold the key to preventing Alzheimer's disease

by CORDISCredit: IRHOM2 in ADIt is known that the onset of Alzheimer's disease (AD) is associated with the accumulation of Amyloid beta (Aβ) peptides in small molecular clusters known as olig

Updated on: March 09,2024

Control of the iRhom2 protein may hold the key to preventing Alzheimer's disease

by CORDISCredit: IRHOM2 in ADIt is known that the onset of Alzheimer's disease (AD) is associated with the accumulation of Amyloid beta (Aβ) peptides in small molecular clusters known as olig

Updated on:March 09,2024

Body's immune system may play larger role in Alzheimer's disease than thought

by University of California, IrvineMicroglia (green) surround an amyloid plaque (blue) in the brain of an Alzheimer's disease mouse model. UCI researchers have shown that endogenous mouse ant

Updated on: February 28,2024

Body's immune system may play larger role in Alzheimer's disease than thought

by University of California, IrvineMicroglia (green) surround an amyloid plaque (blue) in the brain of an Alzheimer's disease mouse model. UCI researchers have shown that endogenous mouse ant

Updated on:February 28,2024

Antidepressant use increases risk of head injuries among persons with Alzheimer's disease

by University of Eastern FinlandAntidepressant use is associated with an increased risk of head injuries and traumatic brain injuries among persons with Alzheimer's disease, according to a ne

Updated on: March 07,2024

Antidepressant use increases risk of head injuries among persons with Alzheimer's disease

by University of Eastern FinlandAntidepressant use is associated with an increased risk of head injuries and traumatic brain injuries among persons with Alzheimer's disease, according to a ne

Updated on:March 07,2024