Alzheimer's disease risk gene APOE4 impairs function of brain immune cells

by University of Eastern FinlandThe induced pluripotent stem cell (iPSC) -derived microglia demonstrate that apolipoprotein E4 (APOE4) has a profound impact on several functions of human brain im

Updated on: April 08,2024 18

Alzheimer's disease risk gene APOE4 impairs function of brain immune cells

by University of Eastern FinlandThe induced pluripotent stem cell (iPSC) -derived microglia demonstrate that apolipoprotein E4 (APOE4) has a profound impact on several functions of human brain im

Updated on:April 08,2024 18

Blood-based marker for Alzheimer's disease shows diagnostic potential

by Alzheimer's Research UKDiagram of the brain of a person with Alzheimer's Disease. Credit: Wikipedia/public domain.Researchers in Japan and Australia have used the ratio of different fo

Updated on: April 08,2024 15

Blood-based marker for Alzheimer's disease shows diagnostic potential

by Alzheimer's Research UKDiagram of the brain of a person with Alzheimer's Disease. Credit: Wikipedia/public domain.Researchers in Japan and Australia have used the ratio of different fo

Updated on:April 08,2024 15

Alzheimer's advance: Early stage study in mice show new drugs restore memory loss and prolong life

by University of LeicesterPicture of nerve cells dying in the brain of prion-diseased mice. The nerves are stained pink and can be seen dying in the CA1 region of the hippocampus. Credit: Univers

Updated on: April 07,2024 12

Alzheimer's advance: Early stage study in mice show new drugs restore memory loss and prolong life

by University of LeicesterPicture of nerve cells dying in the brain of prion-diseased mice. The nerves are stained pink and can be seen dying in the CA1 region of the hippocampus. Credit: Univers

Updated on:April 07,2024 12

New computational model proposed for Alzheimer's disease

by Susan Barber Lindquist,Mayo ClinicSurface renderings of glucose eigenbrains. Eigenbrain decomposition of glucose uptake in 423 Alzheimer’s patients reveals a low-dimensional set of large-scal

Updated on: April 07,2024 19

New computational model proposed for Alzheimer's disease

by Susan Barber Lindquist,Mayo ClinicSurface renderings of glucose eigenbrains. Eigenbrain decomposition of glucose uptake in 423 Alzheimer’s patients reveals a low-dimensional set of large-scal

Updated on:April 07,2024 19

Alzheimer's risk gene disrupts endocytosis, but another disease-linked gene could help

by Massachusetts Institute of TechnologyAPOE4 Astrocytes showed an increase in endocytosis after overexpression of PICALM. In the bottom row, astrocytes (labeled blue), have taken up more of a pr

Updated on: April 07,2024 18

Alzheimer's risk gene disrupts endocytosis, but another disease-linked gene could help

by Massachusetts Institute of TechnologyAPOE4 Astrocytes showed an increase in endocytosis after overexpression of PICALM. In the bottom row, astrocytes (labeled blue), have taken up more of a pr

Updated on:April 07,2024 18

New biological research framework for Alzheimer's seeks to spur discovery

by National Institutes of HealthThis table shows column of the eight biomarker profiles (left) and corresponding categories (right) outlined in the framework that could be used to group research

Updated on: April 07,2024 13

New biological research framework for Alzheimer's seeks to spur discovery

by National Institutes of HealthThis table shows column of the eight biomarker profiles (left) and corresponding categories (right) outlined in the framework that could be used to group research

Updated on:April 07,2024 13

A potential new treatment target for Alzheimer's disease

by Keck School of Medicine of USCActivation of cyclophilin A (CypA; red upper panels) leads to activation of MMP9 (red lower panels) in CD13+-pericytes (green) in brain capillaries of APOE4 human

Updated on: April 07,2024 19

A potential new treatment target for Alzheimer's disease

by Keck School of Medicine of USCActivation of cyclophilin A (CypA; red upper panels) leads to activation of MMP9 (red lower panels) in CD13+-pericytes (green) in brain capillaries of APOE4 human

Updated on:April 07,2024 19

Rate of Alzheimer's deaths on the rise

by Pennsylvania State UniversityCredit: Thinkstock/monkeybusinessimagesThe rate of death from Alzheimer's disease in the United States increased by more than 50 percent in the past 15 years,

Updated on: April 07,2024 13

Rate of Alzheimer's deaths on the rise

by Pennsylvania State UniversityCredit: Thinkstock/monkeybusinessimagesThe rate of death from Alzheimer's disease in the United States increased by more than 50 percent in the past 15 years,

Updated on:April 07,2024 13

Alzheimer's risk factors may be measurable in adolescents and young adults

by Alzheimer's AssociationCredit: CC0 Public DomainRisk factors for Alzheimer's dementia may be apparent as early as our teens and 20s, according to new research reported at the Alzheimer'

Updated on: April 07,2024 10

Alzheimer's risk factors may be measurable in adolescents and young adults

by Alzheimer's AssociationCredit: CC0 Public DomainRisk factors for Alzheimer's dementia may be apparent as early as our teens and 20s, according to new research reported at the Alzheimer'

Updated on:April 07,2024 10

New clues to Alzheimer's disease

by Alvin Powell,Harvard UniversityHarvard University McLean researchers Bruce Cohen, left, and Kai Sonntag have found an energy dysfunction in the cells of late-onset Alzheimer's patients, a

Updated on: April 07,2024 15

New clues to Alzheimer's disease

by Alvin Powell,Harvard UniversityHarvard University McLean researchers Bruce Cohen, left, and Kai Sonntag have found an energy dysfunction in the cells of late-onset Alzheimer's patients, a

Updated on:April 07,2024 15

Cerebrovascular abnormalities in Alzheimer's disease: An adrenergic approach

by Impact Journals LLCΑ1AR-mediated downstream signaling pathway involved in Aβ-induced cerebrovascular abnormalities. Credit: Song LiAging-UShas published "Involvement of cerebrovascular a

Updated on: April 07,2024 13

Cerebrovascular abnormalities in Alzheimer's disease: An adrenergic approach

by Impact Journals LLCΑ1AR-mediated downstream signaling pathway involved in Aβ-induced cerebrovascular abnormalities. Credit: Song LiAging-UShas published "Involvement of cerebrovascular a

Updated on:April 07,2024 13

New pathway in Alzheimer's disease provides earlier target for potential therapies

by Case Western Reserve UniversityCredit: CC0 Public DomainResearchers at the Case Western Reserve University School of Medicine have identified a new target in development of Alzheimer's dis

Updated on: April 07,2024 16

New pathway in Alzheimer's disease provides earlier target for potential therapies

by Case Western Reserve UniversityCredit: CC0 Public DomainResearchers at the Case Western Reserve University School of Medicine have identified a new target in development of Alzheimer's dis

Updated on:April 07,2024 16