GHK-Cu and Thymosin-Beta 4 play an essential part in hair development

By Esmée Telman 

  3 Februari 2023 

 > Hair-care

The subject of today's article will be the most effective peptides for promoting hair growth. If you are curious about finding out more, keep reading this piece!

Androgenic alopecia, often known as male-pattern baldness, is the most prevalent kind of hair loss in males and a less common cause of hair loss in females. Medical diseases, including hypothyroidism, medications like oral contraceptives, nutritional inadequacies, physiological and mental pressures, and hormonal fluctuations, are typical reasons for female hair loss. Hair thinning in females as they age may have more than one underlying cause. One research of 100 female subjects found that psychological stress (30%), fever (33%), abortion and delivery (21%), trauma or surgical operations (13%), and hypothyroidism (10%) were likely reasons for their scattered hair loss. Over half of the subjects who experienced hair loss had more than one possible explanation. In 6% of cases, however, researchers could not pinpoint a specific factor.

The significant prevalence and phenotypic variability of male and female pattern hair loss can be attributed to the polygenic nature of both disorders. Epigenetic alterations may cause a change in a body's genetic predisposition.

Androgen receptor (AR) gene variants are associated with male pattern baldness, although polymorphisms in aromatase (CYP19A1), estrogen receptor-a (ESR1), type I 5-alpha reductase (SRD5A1), and insulin-like growth factor 2 (IGF-2).

Female pattern hair loss has received less attention and fewer robust studies exploring genetic links than male pattern hair loss. Given that AR is situated on the X chromosome, which is inactivated in females, studying the link between AR and female pattern hair loss has been challenging. Genome-wide association studies have linked a variety of the CYP19A1 gene to an increased risk of female pattern baldness.

It is commonly known that hair loss can harm one's sense of identity and confidence. According to one study, the psychological impact of hair loss appears to be more severe in females than in males, and researchers found this to be the case for both sexes experiencing hair loss due to different causes. Therefore, a treatment that can promote healthy hair growth in female test subjects is greatly sought.

What, then, is a neurorestorative treatment? The studies suggest that GHK-Cu and Thymosin Beta-4 peptide could be among the most effective treatments.

GHK-Cu

The New Gene Data Reveal the Regenerative and Protective Roles of the GHK-Cu Peptide

Our current understanding suggests that the various biological effects of the peptide GHK (glycyl-l-histidyl-l-lysine) are beneficial to health. It promotes the activity of dermal fibroblasts, which in turn promotes the formation of new blood vessels and nerves, as well as an increase in the synthesis of collagen, elastin, and glycosaminoglycans. Skin, lung connective tissue, boney tissue, liver, and stomach lining are only a few of the tissues for which GHK has been shown to enhance tissue repair.

Multiple anti-cancer activities, anti-inflammatory actions, lung protection and restoration of COPD fibroblasts, suppression of molecules thought to accelerate the diseases of aging like NFB, anti-anxiety, anti-pain, and anti-aggression activities, DNA repair, and activation of cell cleansing via the proteasome system are just some of the decisive cell protective actions attributed to GHK. Recent genetic data suggest various biochemical pathways mediated by GHK, which may explain this wide range of protective and therapeutic effects from a single molecule.

Thymosin Beta-4

Thymosin beta 4, a polypeptide of 43 amino acids, promotes angiogenesis and wound healing and its role as a modulator of cell migration and differentiation. This study shows that Thymosin beta 4 promotes hair development in healthy rats and mice. During the hair-growth phase in mice, Thymosin beta 4 is expressed in a highly coordinated fashion by a subpopulation of keratinocytes in hair follicles.

The hair follicle bulge is a specialized area where skin stem cells can proliferate and give rise to mature keratinocytes. Isolation of clonogenic keratinocytes from the rat vibrissa follicle, which is highly similar to the stem cells found in the bulge, and the subsequent stimulation of their migration and differentiation by nanomolar doses of Thymosin beta 4.

Thymosin beta4 induced the expression and secretion of matrix metalloproteinase-2, an enzyme responsible for degrading the extracellular matrix. Thymosin beta 4 affects critical events in the active phase of the hair follicle cycle, such as promoting the migration of stem cells and their immediate progeny to the base of the follicle, differentiation, and remodeling of the extracellular matrix, which all contribute to a faster rate of hair growth.

Conclusion

In conclusion, GHK-Cu and Thymosin-Beta 4 have been found to play an essential part in hair development. Overexpression of GHK-Cu and T4 has been proven to stimulate hair development, whereas their absence has been shown to inhibit it.