Chronic lactate exposure leads to cellular disruptions implicated in cancer and possibly T2 diabetes

by CU Anschutz Medical CampusCredit: CC0 Public DomainAcute amounts of lactate like those generated during exercise are probably required for healthy cells, but chronic exposure causes cellular d

Updated on: February 05,2024

Chronic lactate exposure leads to cellular disruptions implicated in cancer and possibly T2 diabetes

by CU Anschutz Medical CampusCredit: CC0 Public DomainAcute amounts of lactate like those generated during exercise are probably required for healthy cells, but chronic exposure causes cellular d

Updated on:February 05,2024

The neonatal ketone body is important for primordial follicle pool formation and regulates ovarian aging in mice

by Higher Education PressThe working model for the function of ketone bodies in formation of primordial follicle pool. Credit: Xin-Ying Wang et alPremature ovarian aging (POA) refers to an early decli

Updated on: February 21,2024

The neonatal ketone body is important for primordial follicle pool formation and regulates ovarian aging in mice

by Higher Education PressThe working model for the function of ketone bodies in formation of primordial follicle pool. Credit: Xin-Ying Wang et alPremature ovarian aging (POA) refers to an early decli

Updated on:February 21,2024

Timing calorie intake synchronizes circadian rhythms across multiple systems in mice

by Salk InstituteGraphical abstract. Credit:Cell Metabolism(2023). DOI: 10.1016/j.cmet.2022.12.006Numerous studies have shown health benefits of time-restricted eating including incre

Updated on: January 31,2024

Timing calorie intake synchronizes circadian rhythms across multiple systems in mice

by Salk InstituteGraphical abstract. Credit:Cell Metabolism(2023). DOI: 10.1016/j.cmet.2022.12.006Numerous studies have shown health benefits of time-restricted eating including incre

Updated on:January 31,2024

Inhibiting production of a key material biosynthesis to slow tumor growth

by Will Doss,Northwestern UniversitySAM inhibitor drastically reduced cancer growth in models of human cancer. Credit: Northwestern UniversityMany cancers hijack a metabolic mechanism known as t

Updated on: February 21,2024

Inhibiting production of a key material biosynthesis to slow tumor growth

by Will Doss,Northwestern UniversitySAM inhibitor drastically reduced cancer growth in models of human cancer. Credit: Northwestern UniversityMany cancers hijack a metabolic mechanism known as t

Updated on:February 21,2024

Mom's dietary fat rewires male and female brains differently

by Duke UniversityA microglia (in magenta) from a male mouse born to a mom on a high-fat diet, which sequesters more brain serotonin (in green) than males with mom’s eating a typical lab diet. Th

Updated on: February 21,2024

Mom's dietary fat rewires male and female brains differently

by Duke UniversityA microglia (in magenta) from a male mouse born to a mom on a high-fat diet, which sequesters more brain serotonin (in green) than males with mom’s eating a typical lab diet. Th

Updated on:February 21,2024

Reducing stress on T cells makes them better cancer fighters

bySalk InstituteExhausted killer T cells with higher expression of the noradrenaline receptor ADRB1 (cyan) surround sympathetic nerves (yellow) in a virally infected spleen. Killer T cells witho

Updated on: January 20,2024

Reducing stress on T cells makes them better cancer fighters

bySalk InstituteExhausted killer T cells with higher expression of the noradrenaline receptor ADRB1 (cyan) surround sympathetic nerves (yellow) in a virally infected spleen. Killer T cells witho

Updated on:January 20,2024

Dominant form of heart failure caused by metabolic-immune interaction, review article suggests

by UT Southwestern Medical CenterCredit: Pixabay/CC0 Public DomainThe dominant form of heart failure worldwide appears to be caused by a strong, bidirectional interaction between the body's r

Updated on: February 19,2024

Dominant form of heart failure caused by metabolic-immune interaction, review article suggests

by UT Southwestern Medical CenterCredit: Pixabay/CC0 Public DomainThe dominant form of heart failure worldwide appears to be caused by a strong, bidirectional interaction between the body's r

Updated on:February 19,2024

SMNDC1 loss induces alpha cells to produce insulin

by Austrian Academy of SciencesImmunofluorescence images of alpha cells highlighting induction of insulin protein upon loss of SMNDC1. Credit: Tamara Casteels,CellReport 2022.Beta cells in

Updated on: January 28,2024

SMNDC1 loss induces alpha cells to produce insulin

by Austrian Academy of SciencesImmunofluorescence images of alpha cells highlighting induction of insulin protein upon loss of SMNDC1. Credit: Tamara Casteels,CellReport 2022.Beta cells in

Updated on:January 28,2024

Findings shed light on the cellular mechanisms causing insulin resistance

byUniversity of MontrealCredit:Diabetes(2024). DOI: 10.2337/db23-0802Recent researchpublishedin the journalDiabetessheds new light on the cellular mechanisms

Updated on: September 02,2024

Findings shed light on the cellular mechanisms causing insulin resistance

byUniversity of MontrealCredit:Diabetes(2024). DOI: 10.2337/db23-0802Recent researchpublishedin the journalDiabetessheds new light on the cellular mechanisms

Updated on:September 02,2024

Implanted cells triggered by electricity used to drive in vivo gene expression

by Justin Jackson , Medical XpressDesign of the direct-current-activated transgene expression switch in mammalian cells.a, Schematic illustration of the stimulation setup for monolayer cultures.

Updated on: January 24,2024

Implanted cells triggered by electricity used to drive in vivo gene expression

by Justin Jackson , Medical XpressDesign of the direct-current-activated transgene expression switch in mammalian cells.a, Schematic illustration of the stimulation setup for monolayer cultures.

Updated on:January 24,2024

Clinical trial identifies potential new treatment for liver disease

Clinical trial identifies potential new treatment for liver diseasebyUniversity of California - San DiegoCredit: Pixabay/CC0 Public DomainResearchers at the University of California San Diego Sc

Updated on: January 24,2024

Clinical trial identifies potential new treatment for liver disease

Clinical trial identifies potential new treatment for liver diseasebyUniversity of California - San DiegoCredit: Pixabay/CC0 Public DomainResearchers at the University of California San Diego Sc

Updated on:January 24,2024

GDF15 hormone found to make insulin work better

byUniversity of CopenhagenGraphical abstract. Credit:Cell Metabolism(2023). DOI: 10.1016/j.cmet.2023.06.016More than 500 million people worldwide suffer from diabetes. Roughly 2.6 bi

Updated on: January 17,2024

GDF15 hormone found to make insulin work better

byUniversity of CopenhagenGraphical abstract. Credit:Cell Metabolism(2023). DOI: 10.1016/j.cmet.2023.06.016More than 500 million people worldwide suffer from diabetes. Roughly 2.6 bi

Updated on:January 17,2024