Chronic lactate exposure leads to cellular disruptions implicated in cancer and possibly T2 diabetes

by CU Anschutz Medical CampusCredit: CC0 Public DomainAcute amounts of lactate like those generated during exercise are probably required for healthy cells, but chronic exposure causes cellular d

Updated on: February 05,2024

Chronic lactate exposure leads to cellular disruptions implicated in cancer and possibly T2 diabetes

by CU Anschutz Medical CampusCredit: CC0 Public DomainAcute amounts of lactate like those generated during exercise are probably required for healthy cells, but chronic exposure causes cellular d

Updated on:February 05,2024

Inhibiting production of a key material biosynthesis to slow tumor growth

by Will Doss,Northwestern UniversitySAM inhibitor drastically reduced cancer growth in models of human cancer. Credit: Northwestern UniversityMany cancers hijack a metabolic mechanism known as t

Updated on: February 21,2024

Inhibiting production of a key material biosynthesis to slow tumor growth

by Will Doss,Northwestern UniversitySAM inhibitor drastically reduced cancer growth in models of human cancer. Credit: Northwestern UniversityMany cancers hijack a metabolic mechanism known as t

Updated on:February 21,2024

Mouse study: A neural circuit for the suppression of feeding under persistent pain

by Bob Yirka , Medical XpressCredit: Pixabay/CC0 Public DomainA team of researchers from the University of Science and Technology of China and The Second Affiliated Hospital of Anhui Medical Universit

Updated on: February 21,2024

Mouse study: A neural circuit for the suppression of feeding under persistent pain

by Bob Yirka , Medical XpressCredit: Pixabay/CC0 Public DomainA team of researchers from the University of Science and Technology of China and The Second Affiliated Hospital of Anhui Medical Universit

Updated on:February 21,2024

Lifestyle may counter genetic risk for thyroid cancer

by Lori Solomon HealthDay ReporterGenetic and lifestyle factors are independently associated with incident thyroid cancer, according to a study published online Dec. 12 inJAMA Network Open.Xiumi

Updated on: February 21,2024

Lifestyle may counter genetic risk for thyroid cancer

by Lori Solomon HealthDay ReporterGenetic and lifestyle factors are independently associated with incident thyroid cancer, according to a study published online Dec. 12 inJAMA Network Open.Xiumi

Updated on:February 21,2024

Reducing stress on T cells makes them better cancer fighters

bySalk InstituteExhausted killer T cells with higher expression of the noradrenaline receptor ADRB1 (cyan) surround sympathetic nerves (yellow) in a virally infected spleen. Killer T cells witho

Updated on: January 20,2024

Reducing stress on T cells makes them better cancer fighters

bySalk InstituteExhausted killer T cells with higher expression of the noradrenaline receptor ADRB1 (cyan) surround sympathetic nerves (yellow) in a virally infected spleen. Killer T cells witho

Updated on:January 20,2024

A coming wave of diabetes? The link with COVID-19

by Alice McCarthy,Children's Hospital BostonCredit: Unsplash/CC0 Public DomainResearchers are observing a new long-term health concern in patients hospitalized with COVID-19—an increase in n

Updated on: February 03,2024

A coming wave of diabetes? The link with COVID-19

by Alice McCarthy,Children's Hospital BostonCredit: Unsplash/CC0 Public DomainResearchers are observing a new long-term health concern in patients hospitalized with COVID-19—an increase in n

Updated on:February 03,2024

Removing a protein could prevent aging and obesity from evolving into metabolic diseases, research suggests

byUniversity of CopenhagenThe ribotoxic stress response drives metabolic maladaptation in obesity and aging. ROS are a physiologically relevant source of translational impairment and activation

Updated on: January 18,2024

Removing a protein could prevent aging and obesity from evolving into metabolic diseases, research suggests

byUniversity of CopenhagenThe ribotoxic stress response drives metabolic maladaptation in obesity and aging. ROS are a physiologically relevant source of translational impairment and activation

Updated on:January 18,2024

Scientists discover roles of hypothalamic amino acid sensing in antidepressant effects

by Higher Education PressDeprivation of an essential amino acid leucine exhibits antidepressant effects under chronic stress by stimulating GCN2 and neural activity in AgRP neurons. Credit: Feixiang Y

Updated on: February 03,2024

Scientists discover roles of hypothalamic amino acid sensing in antidepressant effects

by Higher Education PressDeprivation of an essential amino acid leucine exhibits antidepressant effects under chronic stress by stimulating GCN2 and neural activity in AgRP neurons. Credit: Feixiang Y

Updated on:February 03,2024

Study shows that AgRP neurons encode circadian feeding time in mice

by Ingrid Fadelli , Medical XpressImage of the AgRP neurons. Credit: Hyojin Kim (University of Iowa).Animals and humans follow specific daily patterns known as circadian rhythms, which naturally promp

Updated on: January 19,2024

Study shows that AgRP neurons encode circadian feeding time in mice

by Ingrid Fadelli , Medical XpressImage of the AgRP neurons. Credit: Hyojin Kim (University of Iowa).Animals and humans follow specific daily patterns known as circadian rhythms, which naturally promp

Updated on:January 19,2024

The neonatal ketone body is important for primordial follicle pool formation and regulates ovarian aging in mice

by Higher Education PressThe working model for the function of ketone bodies in formation of primordial follicle pool. Credit: Xin-Ying Wang et alPremature ovarian aging (POA) refers to an early decli

Updated on: February 21,2024

The neonatal ketone body is important for primordial follicle pool formation and regulates ovarian aging in mice

by Higher Education PressThe working model for the function of ketone bodies in formation of primordial follicle pool. Credit: Xin-Ying Wang et alPremature ovarian aging (POA) refers to an early decli

Updated on:February 21,2024

GDF15 hormone found to make insulin work better

byUniversity of CopenhagenGraphical abstract. Credit:Cell Metabolism(2023). DOI: 10.1016/j.cmet.2023.06.016More than 500 million people worldwide suffer from diabetes. Roughly 2.6 bi

Updated on: January 17,2024

GDF15 hormone found to make insulin work better

byUniversity of CopenhagenGraphical abstract. Credit:Cell Metabolism(2023). DOI: 10.1016/j.cmet.2023.06.016More than 500 million people worldwide suffer from diabetes. Roughly 2.6 bi

Updated on:January 17,2024

Study indicates surge in GLP-1RA prescriptions to treat obesity and prevent its complications

byCedars-Sinai Medical CenterCredit: Pixabay/CC0 Public DomainInvestigators at Cedars-Sinai and other institutions conducted a nationwide, population-based study to identify trends in the use of

Updated on: July 23,2024

Study indicates surge in GLP-1RA prescriptions to treat obesity and prevent its complications

byCedars-Sinai Medical CenterCredit: Pixabay/CC0 Public DomainInvestigators at Cedars-Sinai and other institutions conducted a nationwide, population-based study to identify trends in the use of

Updated on:July 23,2024