by Cell Press

Average facial temperatures of three aging-status groups among women 50–60 years old. Credit: Zhengqing Yu and Jing-Dong J Han

A colder nose and warmer cheeks may be a telltale sign of rising blood pressure. Researchers discovered that temperatures in different face regions are associated with various chronic illnesses, such as diabetes and high blood pressure. These temperature differences are not easily perceptible by one's own touch but can instead be identified using specific AI-derived spatial temperature patterns that require a thermal camera and a data-trained model.

The results appeared July 2 in the journal Cell Metabolism. With further research, doctors could one day use this simple and non-invasive approach for early detection of diseases.

"Aging is a natural process," says Jing-Dong Jackie Han, the paper's corresponding author at Peking University in Beijing. "But our tool has the potential to promote healthy aging and help people live disease-free."

The team had previously used 3D facial structure to predict people's biological age, which indicates how well the body is aging. Biological age is closely related to the risk of diseases, including cancer and diabetes. They were curious if other features of the face, such as temperature, could also predict aging rate and health status.

Han and her colleagues analyzed facial temperatures of more than 2,800 Chinese participants between the ages of 21 and 88. Then, the researchers used the information to train AI models that could predict a person's thermal age. They identified several key facial regions where the temperatures were significantly related to age and health, including the nose, eyes and cheeks.

The team found the temperature of the nose decreases with age at a rate faster than other parts of the face, meaning people with warmer noses have a younger thermal age. At the same time, temperatures around the eyes tend to increase with age.

The team also found that people with metabolic disorders such as diabetes and fatty liver disease had faster thermal aging. They tended to have higher eye area temperatures than their healthy counterparts of the same age. People with elevated blood pressure also had higher cheek temperatures.

By analyzing participants' blood samples, the team revealed that the increase in temperatures around the eyes and cheeks was mainly because of an increase in cellular activities related to inflammation, such as repairing damaged DNAs and fighting infections. The increase in these activities led to a rise in temperatures in certain facial regions.

"The thermal clock is so strongly associated with metabolic diseases that previous facial imaging models were not able to predict these conditions," Han says.

Due to this connection, the team set out to test if exercise could influence thermal age. They asked 23 participants to jump rope for at least 800 times daily for two weeks. To the team's surprise, these participants reduced their thermal age by five years after just two weeks of exercise.

Next, the team wants to explore if they can use thermal facial imaging to predict other diseases, such as sleeping disorders or cardiovascular problems.

"We hope to apply thermal facial imaging in clinical settings, as it holds significant potential for early disease diagnosis and intervention," Han says.

More information: Yu et al. Thermal Face Image Analyses Reveal Quantitative Hallmarks of Aging and Metabolic Diseases, Cell Metabolism (2024). DOI: 10.1016/j.cmet.2024.05.012. www.cell.com/cell-metabolism/f … 1550-4131(24)00188-8

Journal information: Cell Metabolism 

Provided by Cell Press