by The University of Hong Kong

Alteration of core, common, and unique viruses after H. pylori eradication therapy. a Boxplots show the comparison of richness of viral species at each prevalence level (core, common, and unique) among the three groups (two-sided Wilcoxon tests and adjusted by Benjamini–Hochberg (BH) method for multiple comparisons; Baseline, N = 44; 6-week, N = 44; 6-month, N = 33). b Stacked plots show the proportion of core, common, and unique viral species at baseline (BL, N = 44), 6-week (6 W, N = 44), and 6-month (6 M, N = 33). The boxes denote the lower 25% quantile, upper 75% quantile, and center line the median, with whiskers extending to a limit of ±1.5 interquartile ranges (IQRs). Credit: Nature Communications (2023). DOI: 10.1038/s41467-023-37975-y

A research team led by Professor Leung Wai-keung from Department of Medicine, School of Clinical Medicine, LKS Faculty of Medicine, the University of Hong Kong (HKUMed) and the Baylor College of Medicine of the United States found that Helicobacter pylori (H. pylori) infection around the world has been steadily declining over the past four decades, thus offering a comprehensive, updated epidemiology of H. pylori infection. The study has been published in The Lancet Gastroenterology & Hepatology.

In a separate study on the combination of antibiotics and acid suppressive therapies, Professor Leung's research team discovered that the use of antibiotics could alter the micro-organisms and the virus community (virome) present in the gut. The findings have been published in the Nature Communications.

Helicobacter pylori (H. pylori) is the major cause of gastric cancer as well as peptic ulcer disease. It was previously estimated that about 50% of the world's population are being infected with this bacterium, particularly in Asia including China. HKUMed and the Baylor College of Medicine of the United States provided a systematic review and meta-analysis on epidemiology of H. pylori infection in the world over the past four decades, which included 224 studies from 71 countries.

The study found that the global prevalence of H. pylori infection has been declining from 58.2% in the decade 1980–1990 to 43.1% in the period 2011–2022. On average, there was a decline of about 0.39–0.83% per year in the prevalence of H. pylori infection in the world. The decline is particularly marked in the last decade (2010–2020), and is evidenced in all six World Health Organization (WHO) regions (Africa, the Americas, Europe, Eastern Mediterranean, South-East Asia and Western Pacific), or according to the World Bank income or the WHO universal health coverage level of the country or region.

The latest estimation shows that more than 40% of the adult population in the world is still infected with H. pylori. This could still pose a major burden on the health care system, especially on the morbidity and mortality related to peptic ulcer disease and gastric cancer.

Eradication of H. pylori by combination of antibiotics and acid suppressive therapies could substantially reduce the risk of subsequent gastric cancer development as well as ulcer complications. However, the use of antibiotics could also accidentally alter the micro-organisms present in the gut (or gut microbiome). Professor Leung's research team showed that not only the gut bacteria could be inadvertently altered by antibiotics used in H. pylori eradication, but the virus community (virome) present in the gut could also be reshaped.

With the use of metagenomic sequencing techniques, they found a contraction of virome diversity after treatment for H. pylori. Unlike changes in gut bacteria composition which can typically restored at six months, the contraction in the virus community persists for more than six months. Multiple courses of antibiotic treatments further lower the virus community diversity.

Professor Leung Wai-keung said, "Despite a considerable fall in the overall prevalence of H. pylori in the world over the past 40 years, the burden of this infection in some regions is still high, particularly when considering this is a cancer-causing agent. Our results could help to inform planning for stomach cancer prevention in different regions and reiterate the importance of continuous monitoring of latest infection status.

"The second study highlighted the potential impact of antibiotics treatment on the alteration of virus community of the gut, which could impact individual's health as well as antibiotics resistance through modification of the bacteriophages present in gut."

More information: Yunhao Li et al, Global prevalence of Helicobacter pylori infection between 1980 and 2022: a systematic review and meta-analysis, The Lancet Gastroenterology & Hepatology (2023). DOI: 10.1016/S2468-1253(23)00070-5

Lingling Wang et al, Altered human gut virome in patients undergoing antibiotics therapy for Helicobacter pylori, Nature Communications (2023). DOI: 10.1038/s41467-023-37975-y

Journal information: Nature Communications 

Provided by The University of Hong Kong