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Hematology&Oncology
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A new immunotherapy target? How SRC-3 in Tregs may reshape solid-tumor treatment

A new immunotherapy target? How SRC-3 in Tregs may reshape solid-tumor treatment

by Ana María Rodríguez,Baylor College of MedicineThe loss of SRC-3 in Treg leads to immune suppression of glioblastoma in mice: (A) Experimental design for the orthotopic injection of glioblastoma cel

A new immunotherapy target? How SRC-3 in Tregs may reshape solid-tumor treatment

by Ana María Rodríguez,Baylor College of MedicineThe loss of SRC-3 in Treg leads to immune suppression of glioblastoma in mice: (A) Experimental design for the orthotopic injection of glioblastoma cel
Why some cancer therapies don't work for all patients: A tumor backup survival pathway

Why some cancer therapies don't work for all patients: A tumor backup survival pathway

by Anne Trafton,Massachusetts Institute of TechnologyMany of the targeted tumors turn on a backup survival pathway that helps them keep growing when tyrosine kinase—pictured here as strands—is turned

Why some cancer therapies don't work for all patients: A tumor backup survival pathway

by Anne Trafton,Massachusetts Institute of TechnologyMany of the targeted tumors turn on a backup survival pathway that helps them keep growing when tyrosine kinase—pictured here as strands—is turned
Cause or effect? Study answers question about gene linked with colorectal cancer

Cause or effect? Study answers question about gene linked with colorectal cancer

by Jacqueline Mitchell,Harvard Medical SchoolIn mice lacking the COSMC gene, gut cells underwent vast changes in appearance and gene activity that predisposed them to develop into colorectal cancer. H

Cause or effect? Study answers question about gene linked with colorectal cancer

by Jacqueline Mitchell,Harvard Medical SchoolIn mice lacking the COSMC gene, gut cells underwent vast changes in appearance and gene activity that predisposed them to develop into colorectal cancer. H
uPAR-targeted CAR T cells shrank solid tumors and cleared metastases in mice

uPAR-targeted CAR T cells shrank solid tumors and cleared metastases in mice

byMemorial Sloan Kettering Cancer CenterCredit:Cell(2026). DOI: 10.1016/j.cell.2026.03.002Chimeric antigen receptor T-cell therapy—CAR T for short—has been a major advance in treating blood cancers li

uPAR-targeted CAR T cells shrank solid tumors and cleared metastases in mice

byMemorial Sloan Kettering Cancer CenterCredit:Cell(2026). DOI: 10.1016/j.cell.2026.03.002Chimeric antigen receptor T-cell therapy—CAR T for short—has been a major advance in treating blood cancers li
Genetic variants involved in rapid immune response linked to earlier breast cancer onset in BRCA1 carriers

Genetic variants involved in rapid immune response linked to earlier breast cancer onset in BRCA1 carriers

byBritish Medical JournalCredit: CC0 Public DomainDamaging variants in genes involved in a rapid immune response (innate immunity) are significantly linked to earlier breast cancer onset in carriers o

Genetic variants involved in rapid immune response linked to earlier breast cancer onset in BRCA1 carriers

byBritish Medical JournalCredit: CC0 Public DomainDamaging variants in genes involved in a rapid immune response (innate immunity) are significantly linked to earlier breast cancer onset in carriers o
AI learns to make sense of childhood cancer survivors' health care needs

AI learns to make sense of childhood cancer survivors' health care needs

bySt. Jude Children's Research HospitalCredit: SHVETS production from PexelsArtificial intelligence (AI) could help physicians determine if survivors of childhood cancer need extra support—and the

AI learns to make sense of childhood cancer survivors' health care needs

bySt. Jude Children's Research HospitalCredit: SHVETS production from PexelsArtificial intelligence (AI) could help physicians determine if survivors of childhood cancer need extra support—and the
Rearranging tumor cell structures—new approach could treat cancer

Rearranging tumor cell structures—new approach could treat cancer

by Tim Tedeschi,University of CincinnatiBiomedical research typically follows a familiar path: developing treatments that block, enhance or mutate certain signaling pathways, genes or proteins to chan

Rearranging tumor cell structures—new approach could treat cancer

by Tim Tedeschi,University of CincinnatiBiomedical research typically follows a familiar path: developing treatments that block, enhance or mutate certain signaling pathways, genes or proteins to chan
Early results from a trial of active surveillance for low-risk ductal carcinoma in situ are 'reassuring'

Early results from a trial of active surveillance for low-risk ductal carcinoma in situ are 'reassuring'

by European Organisation for Research and Treatment of CancerCredit: Unsplash/CC0 Public DomainResearchers leading a trial of active surveillance for ductal carcinoma in situ (DCIS) have described ear

Early results from a trial of active surveillance for low-risk ductal carcinoma in situ are 'reassuring'

by European Organisation for Research and Treatment of CancerCredit: Unsplash/CC0 Public DomainResearchers leading a trial of active surveillance for ductal carcinoma in situ (DCIS) have described ear
Supportive cancer care: Most patients say human touch outshines tech

Supportive cancer care: Most patients say human touch outshines tech

by National Comprehensive Cancer NetworkCredit: Pixabay/CC0 Public DomainNew researchpublishedin the November 2025 issue ofJNCCN—Journal of the National Comprehensive Cancer Networkexplores the percep

Supportive cancer care: Most patients say human touch outshines tech

by National Comprehensive Cancer NetworkCredit: Pixabay/CC0 Public DomainNew researchpublishedin the November 2025 issue ofJNCCN—Journal of the National Comprehensive Cancer Networkexplores the percep
FDA warns biotech firm over cancer drug claims

FDA warns biotech firm over cancer drug claims

by HealthDay StaffThe U.S. Food and Drug Administration (FDA) has warned a biotech company about claims that its bladder cancer drug could treat and prevent multiple types of cancer.The agency sent a

FDA warns biotech firm over cancer drug claims

by HealthDay StaffThe U.S. Food and Drug Administration (FDA) has warned a biotech company about claims that its bladder cancer drug could treat and prevent multiple types of cancer.The agency sent a
Study shows supervised exercise improves strength, physical performance in patients with advanced breast cancer

Study shows supervised exercise improves strength, physical performance in patients with advanced breast cancer

by Associação Advanced Breast Cancer Global AllianceWhole body lean mass, which is an indicator of muscle mass, increased in the exercise group, while it decreased in the control group. Credit: Anne M

Study shows supervised exercise improves strength, physical performance in patients with advanced breast cancer

by Associação Advanced Breast Cancer Global AllianceWhole body lean mass, which is an indicator of muscle mass, increased in the exercise group, while it decreased in the control group. Credit: Anne M
RNA-based molecule enhances therapies against pancreatic cancer

RNA-based molecule enhances therapies against pancreatic cancer

byItalian Institute of TechnologyThe small ring-like structures visible in the magnified area represent the RAD51 protein, which has adopted a non-functional shape as a result of its interaction with

RNA-based molecule enhances therapies against pancreatic cancer

byItalian Institute of TechnologyThe small ring-like structures visible in the magnified area represent the RAD51 protein, which has adopted a non-functional shape as a result of its interaction with