1.Closed-Loop Insulin Therapy for People With Type 2 Diabetes Treated With an Insulin Pump: A 12-Week Multicenter, Open-Label Randomized, Controlled, Crossover Trial
DOI: 10.2337/dc24-0623
Type 2 diabetes is a chronic disease prevalent worldwide that requires long-term blood glucose management. This study primarily investigates the efficacy of closed-loop insulin therapy. It is a randomized, controlled, crossover, two-phase, open-label, multicenter study, with a total of 17 individuals enrolled for treatment. The results indicate that patients who received closed-loop therapy achieved significantly better blood glucose control compared to those treated with CSII + CGM.
For more detailed information, please refer to the original article.
2.Oxygen-Propelled Dual-Modular Microneedles with Dopamine-Enhanced RNA Delivery for Regulating Each Stage of Diabetic Wounds
DOI: 10.1002/smll.202404538
https://onlinelibrary.wiley.com/doi/10.1002/smll.202404538
Diabetic patients often experience slow wound healing and are prone to recurrent infections. This study addresses this challenge by developing dual-modulus microneedles (MNs) using mask-mediated sequential polymerization and various crosslinking techniques. These MNs feature fast and slow modules with different degradation rates, tailored for the full spectrum of diabetic wound healing. The treatment not only stops bleeding quickly but also accelerates angiogenesis and tissue regeneration while alleviating tissue hypoxia. In summary, these dual-modulus microneedles aid in promoting the healing of diabetic wounds.
For more detailed information, please refer to the original article.
3.Integrated metabolomics and transcriptomics analysis reveals the mechanism of Tangbi capsule for diabetic lower extremities arterial disease
DOI: 10.3389/fmicb.2024.1423428
https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2024.1423428/full
Traditional Chinese medicine has been continuously researching diabetes, and this article primarily introduces a study on Tangbi Capsule (TBC), a traditional herbal formula, for improving diabetic lower extremity vascular insufficiency and limb numbness. The study conducted experiments on rats with diabetic lower extremity arterial disease, discovering that TBC can regulate metabolic pathways related to vascular regeneration, immune-inflammatory response, and cell growth. These pathways include arginine biosynthesis, phenylalanine metabolism, pyrimidine metabolism, arachidonic acid metabolism, nucleotide metabolism, and vitamin B6 metabolism, thereby improving diabetic lower extremity arterial disease (LEAD).
For more detailed information, please refer to the original article.
4.Periodontitis and Diabetes Complications: A Danish Population-Based Study
DOI: 10.1177/00220345241259954
https://journals.sagepub.com/doi/10.1177/00220345241259954
Diabetic patients often experience microvascular diseases, and some evidence suggests a link between diabetes-related microvascular complications and periodontitis. However, small sample sizes and other factors have made these results unreliable. This article presents a population-based study investigating the association between individual and combined diabetic microvascular complications (neuropathy and retinopathy) and moderate/severe periodontitis. The study included a total of 15,992 type 2 diabetes patients and also assessed whether dyslipidemia alters these associations. The findings concluded that diabetic neuropathy and retinopathy, both individually and combined, are associated with moderate/severe periodontitis. Additionally, dyslipidemia has an additive positive effect on these associations, increasing the likelihood of moderate/severe periodontitis.
For more detailed information, please refer to the original article.
5.A Novel Immunodeficient Hyperglycemic Mouse Carrying the Ins1 Akita Mutation for Xenogeneic Islet Cell Transplantation
DOI: 10.1097/TP.0000000000005152
Insulin is a key factor in controlling blood glucose levels, but some diabetic patients struggle to manage their blood sugar even with insulin use. Xenogeneic islet cells, including human stem cell-derived islets (hSC-islet) and porcine islets, offer a promising alternative. This article primarily explores the introduction of the Akita (C96Y) mutation into the rodent-specific Insulin1 gene of NOD/Shi-scid IL2rγcnull (NOG) mice (Ins1C96Y/C96Y NOG) to develop a permanent diabetic immunodeficient mouse model. The study's findings indicate that the Ins1C96Y/C96Y NOG mouse model provides an effective platform for evaluating the long-term efficacy and safety of xenogeneic islet transplants without interference from immune responses. This research holds promise for providing critical foundational information for the clinical application of islet cell transplantation.
For more detailed information, please refer to the original article.
Post comments