TAp63: A new protein drug target for rheumatoid arthritis

by Chiba UniversityGraphical abstract. Credit:JCI Insight(2023). DOI: 10.1172/jci.insight.164778Rheumatoid arthritis (RA) is an autoimmune disease characterized by joint deterioration. The

Updated on: May 08,2024

TAp63: A new protein drug target for rheumatoid arthritis

by Chiba UniversityGraphical abstract. Credit:JCI Insight(2023). DOI: 10.1172/jci.insight.164778Rheumatoid arthritis (RA) is an autoimmune disease characterized by joint deterioration. The

Updated on:May 08,2024

Rheumatoid arthritis finding may lead to new inflammation blockers

by Sara Tiner,Mayo ClinicCredit: Unsplash/CC0 Public DomainMayo Clinic researchers have linked the T cell dysfunction seen in rheumatoid arthritis with a metabolic deficiency, reported in a new&

Updated on: May 29,2024

Rheumatoid arthritis finding may lead to new inflammation blockers

by Sara Tiner,Mayo ClinicCredit: Unsplash/CC0 Public DomainMayo Clinic researchers have linked the T cell dysfunction seen in rheumatoid arthritis with a metabolic deficiency, reported in a new&

Updated on:May 29,2024

Researchers identify new target for rheumatoid arthritis

by Hospital for Special SurgeryCo-senior author and Program Director Carl Blobel, M.D., Ph.D., works with collaborator Lionel Ivashkiv, M.D., in the Arthritis and Tissue Degeneration Program lab

Updated on: March 24,2024

Researchers identify new target for rheumatoid arthritis

by Hospital for Special SurgeryCo-senior author and Program Director Carl Blobel, M.D., Ph.D., works with collaborator Lionel Ivashkiv, M.D., in the Arthritis and Tissue Degeneration Program lab

Updated on:March 24,2024

Lab-created molecule achieves positive results in the treatment of arthritis

by FAPESPArthritic mouse paw treated with TPPU (left) and untreated paw of another arthritic mouse. The substance decreased the area affected, reduced local swelling, and assuaged the pain associ

Updated on: March 24,2024

Lab-created molecule achieves positive results in the treatment of arthritis

by FAPESPArthritic mouse paw treated with TPPU (left) and untreated paw of another arthritic mouse. The substance decreased the area affected, reduced local swelling, and assuaged the pain associ

Updated on:March 24,2024

How does vaccination thwart pneumococcal infection? Animal model uncovers 'capture and kill' scenario

by Delthia Ricks , Medical XpressRepresentative IVM imaging of vaccine-activated capture of ST865 pneumococci in the liver sinusoids. Pneumococci, green; KCs, red; ECs, cyan; neutrophils, magenta. Cre

Updated on: March 07,2024

How does vaccination thwart pneumococcal infection? Animal model uncovers 'capture and kill' scenario

by Delthia Ricks , Medical XpressRepresentative IVM imaging of vaccine-activated capture of ST865 pneumococci in the liver sinusoids. Pneumococci, green; KCs, red; ECs, cyan; neutrophils, magenta. Cre

Updated on:March 07,2024

Examining inflammatory bowel disease after a stem cell transplant

byUniversity of BaselColon sections of the index patient in active IBDvs. clinical remission (under infliximab therapy) were stained by immune histology for CD5 (a pan T cell marker) and f

Updated on: March 27,2024

Examining inflammatory bowel disease after a stem cell transplant

byUniversity of BaselColon sections of the index patient in active IBDvs. clinical remission (under infliximab therapy) were stained by immune histology for CD5 (a pan T cell marker) and f

Updated on:March 27,2024

Study reveals increase in the need for psychology referrals for children with food allergies

byAmerican College of Allergy, Asthma, and ImmunologyCredit: Unsplash/CC0 Public DomainWith the rise in incidence of food allergies in children in the past decade, there has been a corresponding

Updated on: November 01,2024

Study reveals increase in the need for psychology referrals for children with food allergies

byAmerican College of Allergy, Asthma, and ImmunologyCredit: Unsplash/CC0 Public DomainWith the rise in incidence of food allergies in children in the past decade, there has been a corresponding

Updated on:November 01,2024

Lupus, rheumatoid arthritis tied to higher risk for adverse obstetric, birth outcomes

by Lori SolomonWomen with rheumatoid arthritis (RA) or systemic lupus erythematosus (SLE) and their infants experience higher rates of adverse obstetric and birth outcomes, according to a study publis

Updated on: June 15,2024

Lupus, rheumatoid arthritis tied to higher risk for adverse obstetric, birth outcomes

by Lori SolomonWomen with rheumatoid arthritis (RA) or systemic lupus erythematosus (SLE) and their infants experience higher rates of adverse obstetric and birth outcomes, according to a study publis

Updated on:June 15,2024

Mast cell levels may explain sex differences in osteoarthritis pain

by Hospital for Special SurgeryCredit: Pixabay/CC0 Public DomainInvestigators at Hospital for Special Surgery (HSS) have discovered that at the time of total knee replacement, women have signific

Updated on: April 17,2024

Mast cell levels may explain sex differences in osteoarthritis pain

by Hospital for Special SurgeryCredit: Pixabay/CC0 Public DomainInvestigators at Hospital for Special Surgery (HSS) have discovered that at the time of total knee replacement, women have signific

Updated on:April 17,2024

Weight loss predicts mortality in rheumatoid arthritis

(HealthDay)—Weight loss is a strong predictor of mortality in patients with rheumatoid arthritis (RA), according to a study published online June 26 inArthritis & Rheumatology.Joshua F. Bake

Updated on: April 08,2024

Weight loss predicts mortality in rheumatoid arthritis

(HealthDay)—Weight loss is a strong predictor of mortality in patients with rheumatoid arthritis (RA), according to a study published online June 26 inArthritis & Rheumatology.Joshua F. Bake

Updated on:April 08,2024

TNF inhibitors may not modify polyarticular JIA disease process

(HealthDay)—For children with polyarticular juvenile idiopathic arthritis (JIA), discontinuing medications is challenging, with high relapse rates, especially after discontinuation of tumor necrosis f

Updated on: April 08,2024

TNF inhibitors may not modify polyarticular JIA disease process

(HealthDay)—For children with polyarticular juvenile idiopathic arthritis (JIA), discontinuing medications is challenging, with high relapse rates, especially after discontinuation of tumor necrosis f

Updated on:April 08,2024

Anti-cancer virus fits tumor receptor like a 'key in a lock'

by Okinawa Institute of Science and TechnologyA cryo-EM map of the receptor decorated capsid in which a single protomer was replaced with the atomic model. Seneca Valley Virus capsid proteins are

Updated on: April 08,2024

Anti-cancer virus fits tumor receptor like a 'key in a lock'

by Okinawa Institute of Science and TechnologyA cryo-EM map of the receptor decorated capsid in which a single protomer was replaced with the atomic model. Seneca Valley Virus capsid proteins are

Updated on:April 08,2024