Early drug intervention reduces risk of cardiovascular events in rheumatoid arthritis sufferers

by Rebecca Biason,University of TorontoCredit: CC0 Public DomainPeople who develop rheumatoid arthritis as older adults benefit from early and sustained use of a drug called Methotrexate (MTX),

Updated on: March 28,2024

Early drug intervention reduces risk of cardiovascular events in rheumatoid arthritis sufferers

by Rebecca Biason,University of TorontoCredit: CC0 Public DomainPeople who develop rheumatoid arthritis as older adults benefit from early and sustained use of a drug called Methotrexate (MTX),

Updated on:March 28,2024

Study finds primary cilia restrict autoinflammation by mediating PD-L1 expression

by Science China PressLoss of primary cilia results in the downregulation of PD-L1 expression, which contributes to unrestrained local T cell proliferation and activation. Credit: Science China P

Updated on: June 15,2024

Study finds primary cilia restrict autoinflammation by mediating PD-L1 expression

by Science China PressLoss of primary cilia results in the downregulation of PD-L1 expression, which contributes to unrestrained local T cell proliferation and activation. Credit: Science China P

Updated on:June 15,2024

Swimming short fibrous nasal drops achieve intraventricular administration

byScience China PressInspired by swimming fish and the microstructure of the nasal cavity, short-swimming fibrous nasal drops with the ability to transport drugs along the nasal mucosa were inno

Updated on: April 28,2024

Swimming short fibrous nasal drops achieve intraventricular administration

byScience China PressInspired by swimming fish and the microstructure of the nasal cavity, short-swimming fibrous nasal drops with the ability to transport drugs along the nasal mucosa were inno

Updated on:April 28,2024

Early signs of arthritis can be found in the mouth

by University of AdelaideThis is a hand afflicted by rheumatoid arthritis. Credit: The University of ManchesterA common gum disease may indicate a person's risk of developing rheumatoid arthr

Updated on: April 20,2024

Early signs of arthritis can be found in the mouth

by University of AdelaideThis is a hand afflicted by rheumatoid arthritis. Credit: The University of ManchesterA common gum disease may indicate a person's risk of developing rheumatoid arthr

Updated on:April 20,2024

Analysis of DNA reveals weapons used by our immune cells to fight tuberculosis

by Agency for Science, Technology and Research (A*STAR), SingaporeFig. 1: Histone acetylome-wide association study of TB. Credit: DOI: 10.1038/s41564-021-01049-wA study led by the Agency for Scie

Updated on: April 15,2024

Analysis of DNA reveals weapons used by our immune cells to fight tuberculosis

by Agency for Science, Technology and Research (A*STAR), SingaporeFig. 1: Histone acetylome-wide association study of TB. Credit: DOI: 10.1038/s41564-021-01049-wA study led by the Agency for Scie

Updated on:April 15,2024

JAK signaling may be behind polymyalgia rheumatica

by Lori SolomonJanus tyrosine kinase (JAK) signaling may be involved in the pathogenesis of polymyalgia rheumatica (PMR), and tofacitinib may be an effective treatment, according to a pilot study publ

Updated on: April 16,2024

JAK signaling may be behind polymyalgia rheumatica

by Lori SolomonJanus tyrosine kinase (JAK) signaling may be involved in the pathogenesis of polymyalgia rheumatica (PMR), and tofacitinib may be an effective treatment, according to a pilot study publ

Updated on:April 16,2024

A metabolic enzyme as a potential new target for cancer immune therapies

by German Cancer Research CenterCredit: Unsplash/CC0 Public DomainThe metabolic enzyme IL4I1 (Interleukin-4-Induced-1) promotes the spread of tumor cells and suppresses the immune system. This wa

Updated on: May 07,2024

A metabolic enzyme as a potential new target for cancer immune therapies

by German Cancer Research CenterCredit: Unsplash/CC0 Public DomainThe metabolic enzyme IL4I1 (Interleukin-4-Induced-1) promotes the spread of tumor cells and suppresses the immune system. This wa

Updated on:May 07,2024

Cryo-EM imaging of STING protein reveals new binding pocket

by UniversityofTexasSouthwesternMedicalCenterThe synthetic drug-like compound (magenta spheres at the bottom) targets a hidden pocket in STING. This pocket is located at

Updated on: May 07,2024

Cryo-EM imaging of STING protein reveals new binding pocket

by UniversityofTexasSouthwesternMedicalCenterThe synthetic drug-like compound (magenta spheres at the bottom) targets a hidden pocket in STING. This pocket is located at

Updated on:May 07,2024

Here's why B cells benefit from booster shots

byRockefeller UniversityRecall germinal centers formed in response to a secondary infection generate a second line of defense, rebuffing memory B cells in favor of training naive ones. Credit: R

Updated on: October 10,2024

Here's why B cells benefit from booster shots

byRockefeller UniversityRecall germinal centers formed in response to a secondary infection generate a second line of defense, rebuffing memory B cells in favor of training naive ones. Credit: R

Updated on:October 10,2024

Compound found to trigger innate immunity against viruses

by Bobbi Nodell,University of WashingtonCells under a microscope in a UW Medicine immunity lab. Credit: Dennis WiseResearch from UW Medicine and collaborators indicates that a drug-like molecule

Updated on: May 08,2024

Compound found to trigger innate immunity against viruses

by Bobbi Nodell,University of WashingtonCells under a microscope in a UW Medicine immunity lab. Credit: Dennis WiseResearch from UW Medicine and collaborators indicates that a drug-like molecule

Updated on:May 08,2024

Study in mice shows alterations in X-chromosome inactivation predispose female mammals to autoimmune disease

by Bob Yirka , Medical XpressPerturbation of X-inactivation in immune cells ofFtx−/−females.(A) Map of the X inactivation center showing the location ofXist(green) andFtx

Updated on: May 30,2024

Study in mice shows alterations in X-chromosome inactivation predispose female mammals to autoimmune disease

by Bob Yirka , Medical XpressPerturbation of X-inactivation in immune cells ofFtx−/−females.(A) Map of the X inactivation center showing the location ofXist(green) andFtx

Updated on:May 30,2024

Scientists discover two cellular defects appear to drive disease in lupus

byNorthwestern UniversityCredit: Pixabay/CC0 Public DomainNorthwestern Medicine and Brigham and Women's Hospital scientists have discovered a molecular defect that promotes the pathologic im

Updated on: July 11,2024

Scientists discover two cellular defects appear to drive disease in lupus

byNorthwestern UniversityCredit: Pixabay/CC0 Public DomainNorthwestern Medicine and Brigham and Women's Hospital scientists have discovered a molecular defect that promotes the pathologic im

Updated on:July 11,2024