Cryo-EM imaging of STING protein reveals new binding pocket

by UniversityofTexasSouthwesternMedicalCenterThe synthetic drug-like compound (magenta spheres at the bottom) targets a hidden pocket in STING. This pocket is located at

Updated on: May 07,2024

Cryo-EM imaging of STING protein reveals new binding pocket

by UniversityofTexasSouthwesternMedicalCenterThe synthetic drug-like compound (magenta spheres at the bottom) targets a hidden pocket in STING. This pocket is located at

Updated on:May 07,2024

Study: Why people with knee osteoarthritis experience different kinds of pain

by Boston University School of MedicineCredit: CC0 Public DomainOsteoarthritis is the most common form of arthritis worldwide, affecting more than 300 million people. It causes substantial pain,

Updated on: April 17,2024

Study: Why people with knee osteoarthritis experience different kinds of pain

by Boston University School of MedicineCredit: CC0 Public DomainOsteoarthritis is the most common form of arthritis worldwide, affecting more than 300 million people. It causes substantial pain,

Updated on:April 17,2024

Gene variant tied to risk for interstitial lung disease in RA

(HealthDay)—For patients with rheumatoid arthritis (RA), theMUC5Bvariant is associated with an increased risk for RA-associated interstitial lung disease (ILD), according to a study publis

Updated on: June 26,2024

Gene variant tied to risk for interstitial lung disease in RA

(HealthDay)—For patients with rheumatoid arthritis (RA), theMUC5Bvariant is associated with an increased risk for RA-associated interstitial lung disease (ILD), according to a study publis

Updated on:June 26,2024

A pan-cancer platform to help guide patient selection for personalized immunotherapy

by Vall d'Hebron Institute of OncologyGraphical Abstract. Credit:Med(2023). DOI: 10.1016/j.medj.2023.07.006Immunotherapy is a type of cancer treatment that boosts the immune syste

Updated on: May 05,2024

A pan-cancer platform to help guide patient selection for personalized immunotherapy

by Vall d'Hebron Institute of OncologyGraphical Abstract. Credit:Med(2023). DOI: 10.1016/j.medj.2023.07.006Immunotherapy is a type of cancer treatment that boosts the immune syste

Updated on:May 05,2024

Rheumatism drug also effective at half dose

by Medical University of ViennaThe treatment of moderately active rheumatoid arthritis with the tumour necrosis factor inhibitor Etanercept achieves excellent success in more than 80 per cent of

Updated on: March 24,2024

Rheumatism drug also effective at half dose

by Medical University of ViennaThe treatment of moderately active rheumatoid arthritis with the tumour necrosis factor inhibitor Etanercept achieves excellent success in more than 80 per cent of

Updated on:March 24,2024

The importance of treatment goals in PSA

by European Alliance of Associations for Rheumatology (EULAR)Credit: Pixabay/CC0 Public DomainPsA is a type of inflammatory arthritis linked to psoriasis—a chronic condition affecting the skin and nai

Updated on: March 24,2024

The importance of treatment goals in PSA

by European Alliance of Associations for Rheumatology (EULAR)Credit: Pixabay/CC0 Public DomainPsA is a type of inflammatory arthritis linked to psoriasis—a chronic condition affecting the skin and nai

Updated on:March 24,2024

Swimming short fibrous nasal drops achieve intraventricular administration

byScience China PressInspired by swimming fish and the microstructure of the nasal cavity, short-swimming fibrous nasal drops with the ability to transport drugs along the nasal mucosa were inno

Updated on: April 28,2024

Swimming short fibrous nasal drops achieve intraventricular administration

byScience China PressInspired by swimming fish and the microstructure of the nasal cavity, short-swimming fibrous nasal drops with the ability to transport drugs along the nasal mucosa were inno

Updated on:April 28,2024

Fatigue common even with early rheumatoid arthritis

(HealthDay)—Fatigue is prevalent and persistent in early rheumatoid arthritis (RA), according to a study published online Dec. 27 inRheumatology.Onosi Sylvia Ifesemen, M.B.B.S., from the Univers

Updated on: June 17,2024

Fatigue common even with early rheumatoid arthritis

(HealthDay)—Fatigue is prevalent and persistent in early rheumatoid arthritis (RA), according to a study published online Dec. 27 inRheumatology.Onosi Sylvia Ifesemen, M.B.B.S., from the Univers

Updated on:June 17,2024

B cells gone bad could be the culprit in rheumatoid arthritis

by Laurie Fickman,University of HoustonBiomolecular researcher Navin Varadarajan anticipates that his data will serve as a foundation for investigating multiple hypotheses on the roles of B cell

Updated on: April 08,2024

B cells gone bad could be the culprit in rheumatoid arthritis

by Laurie Fickman,University of HoustonBiomolecular researcher Navin Varadarajan anticipates that his data will serve as a foundation for investigating multiple hypotheses on the roles of B cell

Updated on:April 08,2024

AID/APOBECs among important factors in body's defence against SARS-CoV-2

by Johannes Angerer,Medical University of ViennaCredit: Unsplash/CC0 Public DomainTogether with their multifaceted action mechanisms, activation-induced cytidine deaminase (AID) and so-called AP

Updated on: April 08,2024

AID/APOBECs among important factors in body's defence against SARS-CoV-2

by Johannes Angerer,Medical University of ViennaCredit: Unsplash/CC0 Public DomainTogether with their multifaceted action mechanisms, activation-induced cytidine deaminase (AID) and so-called AP

Updated on:April 08,2024

The positive and negative role of LRH-1 during inflammation

by University of KonstanzDetection of immune cells using specific antibodies in tissue sections of the spleen of wild type animals (left panel) and mice with T cell-specific deletion of LRH-1 (ri

Updated on: April 16,2024

The positive and negative role of LRH-1 during inflammation

by University of KonstanzDetection of immune cells using specific antibodies in tissue sections of the spleen of wild type animals (left panel) and mice with T cell-specific deletion of LRH-1 (ri

Updated on:April 16,2024

Researchers develop a handheld white blood cell tracker

by Kitta MacPherson,Rutgers UniversityStudy overview. (A) Image of CytoTracker device prototype. (B) An image of the CytoTracker microfluidic impedance cytometer. (C) Schematic of sensing mechan

Updated on: March 07,2024

Researchers develop a handheld white blood cell tracker

by Kitta MacPherson,Rutgers UniversityStudy overview. (A) Image of CytoTracker device prototype. (B) An image of the CytoTracker microfluidic impedance cytometer. (C) Schematic of sensing mechan

Updated on:March 07,2024