Loosening chimeric antigen receptor's grip on T-regulatory cells improves function, researchers find

by Leslie Cantu,Medical University of South CarolinaCAR and endogenous TCR/CD28 activation result in phenotypically similar Tregs. Credit:Molecular Therapy—Methods & Clinical Developme

Updated on: January 11,2025

Loosening chimeric antigen receptor's grip on T-regulatory cells improves function, researchers find

by Leslie Cantu,Medical University of South CarolinaCAR and endogenous TCR/CD28 activation result in phenotypically similar Tregs. Credit:Molecular Therapy—Methods & Clinical Developme

Updated on:January 11,2025

A metabolic enzyme as a potential new target for cancer immune therapies

by German Cancer Research CenterCredit: Unsplash/CC0 Public DomainThe metabolic enzyme IL4I1 (Interleukin-4-Induced-1) promotes the spread of tumor cells and suppresses the immune system. This wa

Updated on: May 07,2024

A metabolic enzyme as a potential new target for cancer immune therapies

by German Cancer Research CenterCredit: Unsplash/CC0 Public DomainThe metabolic enzyme IL4I1 (Interleukin-4-Induced-1) promotes the spread of tumor cells and suppresses the immune system. This wa

Updated on:May 07,2024

How lockdown impacts those with bone, joint and muscle pain

by University of East AngliaCredit: CC0 Public DomainUniversity of East Anglia researchers are launching a new study to see how COVID-19 and lockdown are affecting people with bone, joint and mus

Updated on: June 01,2024

How lockdown impacts those with bone, joint and muscle pain

by University of East AngliaCredit: CC0 Public DomainUniversity of East Anglia researchers are launching a new study to see how COVID-19 and lockdown are affecting people with bone, joint and mus

Updated on:June 01,2024

T cells alone are sufficient to establish and maintain HIV infection in the brain

by University of North Carolina Health CareScanning electron micrograph of a human T lymphocyte (also called a T cell) from the immune system of a healthy donor. Credit: NIAIDA new study by Unive

Updated on: May 07,2024

T cells alone are sufficient to establish and maintain HIV infection in the brain

by University of North Carolina Health CareScanning electron micrograph of a human T lymphocyte (also called a T cell) from the immune system of a healthy donor. Credit: NIAIDA new study by Unive

Updated on:May 07,2024

CAR NKT cells offer a promising novel immunotherapy for solid tumors

by Molly Chiu,Baylor College of MedicineCredit: CC0 Public DomainNatural killer T (NKT) cells, a type of immune cells known for their potent anti-cancer properties in murine tumor models, have b

Updated on: April 08,2024

CAR NKT cells offer a promising novel immunotherapy for solid tumors

by Molly Chiu,Baylor College of MedicineCredit: CC0 Public DomainNatural killer T (NKT) cells, a type of immune cells known for their potent anti-cancer properties in murine tumor models, have b

Updated on:April 08,2024

Black patients with lupus have three times higher risk of stroke

by American College of RheumatologyCredit: CC0 Public DomainNew research reveals that, in the U.S., Black patients with lupus have a threefold higher risk of stroke and a 24-fold higher risk of i

Updated on: May 23,2024

Black patients with lupus have three times higher risk of stroke

by American College of RheumatologyCredit: CC0 Public DomainNew research reveals that, in the U.S., Black patients with lupus have a threefold higher risk of stroke and a 24-fold higher risk of i

Updated on:May 23,2024

Tofacitinib ups rheumatoid arthritis treatment response

The addition of tofacitinib to rheumatoid arthritis treatment regimens improves patient response to non-biologic disease-modifying antirheumatic drugs, according to a study published in the Aug. 20 is

Updated on: April 08,2024

Tofacitinib ups rheumatoid arthritis treatment response

The addition of tofacitinib to rheumatoid arthritis treatment regimens improves patient response to non-biologic disease-modifying antirheumatic drugs, according to a study published in the Aug. 20 is

Updated on:April 08,2024

X chromosome gene may explain why women are more prone to autoimmune diseases

by Alice Walton,University of California, Los Angeles(A) Using the high-throughput sequencing approach, sexually biased X chromosome genes in CD4+T cells were determined for C57BL/6J naive

Updated on: May 05,2024

X chromosome gene may explain why women are more prone to autoimmune diseases

by Alice Walton,University of California, Los Angeles(A) Using the high-throughput sequencing approach, sexually biased X chromosome genes in CD4+T cells were determined for C57BL/6J naive

Updated on:May 05,2024

Scientists discover possible target for treating and preventing osteoarthritis

by University of FloridaCredit: CC0 Public DomainWear and tear on joints can lead to inflammation, breakdown of cartilage and development of osteoarthritis. Scientists at UF Scripps Biomedical Re

Updated on: April 17,2024

Scientists discover possible target for treating and preventing osteoarthritis

by University of FloridaCredit: CC0 Public DomainWear and tear on joints can lead to inflammation, breakdown of cartilage and development of osteoarthritis. Scientists at UF Scripps Biomedical Re

Updated on:April 17,2024

Antibodies linked to heart attacks

by Karolinska InstitutetCredit: CC0 Public DomainLevels of antiphospholipid antibodies, which are associated with rheumatic diseases, are also elevated in myocardial infarction without any autoim

Updated on: April 08,2024

Antibodies linked to heart attacks

by Karolinska InstitutetCredit: CC0 Public DomainLevels of antiphospholipid antibodies, which are associated with rheumatic diseases, are also elevated in myocardial infarction without any autoim

Updated on:April 08,2024

Common sites of bone erosion in rheumatoid arthritis

(HealthDay)—Joint recesses with bone erosion are more likely to exhibit greater severity of joint inflammation on ultrasound (US) examination, according to a study published online Oct. 25 in the&nbsp

Updated on: May 08,2024

Common sites of bone erosion in rheumatoid arthritis

(HealthDay)—Joint recesses with bone erosion are more likely to exhibit greater severity of joint inflammation on ultrasound (US) examination, according to a study published online Oct. 25 in the&nbsp

Updated on:May 08,2024

Some cases of long COVID-19 may be caused by an abnormally suppressed immune system

by University of California, Los AngelesCredit: Unsplash/CC0 Public DomainA UCLA-led team of researchers studying the effect of the monoclonal antibody Leronlimab on long COVID-19 may have found

Updated on: May 05,2024

Some cases of long COVID-19 may be caused by an abnormally suppressed immune system

by University of California, Los AngelesCredit: Unsplash/CC0 Public DomainA UCLA-led team of researchers studying the effect of the monoclonal antibody Leronlimab on long COVID-19 may have found

Updated on:May 05,2024