ATP from sensory neuron-interneuron crosstalk is key to spreading inflammation in rheumatoid arthritis

by Hokkaido UniversityThe inflammation signal (IL-6 amplifier) in the affected joint (L) causes the secretion of ATP that transmits a signal through the spinal cord (DRG, L5), which in turn trigg

Updated on: June 06,2024

ATP from sensory neuron-interneuron crosstalk is key to spreading inflammation in rheumatoid arthritis

by Hokkaido UniversityThe inflammation signal (IL-6 amplifier) in the affected joint (L) causes the secretion of ATP that transmits a signal through the spinal cord (DRG, L5), which in turn trigg

Updated on:June 06,2024

Findings give hope to plant extract as possible lupus treatment

by University of HoustonNew findings by UH biomedical engineer Chandra Mohan and his team raise hope for a new class of drugs to treat lupus that may not include the long list of adverse risks an

Updated on: June 15,2024

Findings give hope to plant extract as possible lupus treatment

by University of HoustonNew findings by UH biomedical engineer Chandra Mohan and his team raise hope for a new class of drugs to treat lupus that may not include the long list of adverse risks an

Updated on:June 15,2024

We are getting older and heavier, and osteoarthritis is increasing

by Lund UniversityCredit: CC0 Public DomainThe number of patients with osteoarthritis has increased dramatically since the 1950s. Along with diabetes, the illness is now one of the fastest-growin

Updated on: June 01,2024

We are getting older and heavier, and osteoarthritis is increasing

by Lund UniversityCredit: CC0 Public DomainThe number of patients with osteoarthritis has increased dramatically since the 1950s. Along with diabetes, the illness is now one of the fastest-growin

Updated on:June 01,2024

Once considered rare, an itchy dermatologic skin disorder is more common than thought

by Johns Hopkins UniversityCredit: CC0 Public DomainJohns Hopkins researchers report that prurigo nodularis (PN), a skin disease characterized by severely itchy, firm bumps on the skin, may be as

Updated on: April 24,2024

Once considered rare, an itchy dermatologic skin disorder is more common than thought

by Johns Hopkins UniversityCredit: CC0 Public DomainJohns Hopkins researchers report that prurigo nodularis (PN), a skin disease characterized by severely itchy, firm bumps on the skin, may be as

Updated on:April 24,2024

Scientists pioneer immunotherapy technique for autoimmune diseases

byMayo ClinicMSCs are transduced to express CAR and maintain stem-like features following transduction and stimulation. Credit:Nature Biomedical Engineering(2024). DOI: 10.1038/s4155

Updated on: April 06,2024

Scientists pioneer immunotherapy technique for autoimmune diseases

byMayo ClinicMSCs are transduced to express CAR and maintain stem-like features following transduction and stimulation. Credit:Nature Biomedical Engineering(2024). DOI: 10.1038/s4155

Updated on:April 06,2024

'Mix and match' assembly instructions guide immune cell attacks

by Walter and Eliza Hall Institute of Medical ResearchAssociate Professor Matthew Call (left) and Dr Melissa Call discovered a unique way that immune cells respond to, and kill, diseased and canc

Updated on: March 13,2024

'Mix and match' assembly instructions guide immune cell attacks

by Walter and Eliza Hall Institute of Medical ResearchAssociate Professor Matthew Call (left) and Dr Melissa Call discovered a unique way that immune cells respond to, and kill, diseased and canc

Updated on:March 13,2024

How an immune response is driven by one letter difference in DNA

byRadboud UniversityA biphasic circuit regulates IL-1β and IL-37 expression to coordinate pro- and anti-inflammatory processes from within a single TAD. The two functionally opposed states of th

Updated on: January 26,2024

How an immune response is driven by one letter difference in DNA

byRadboud UniversityA biphasic circuit regulates IL-1β and IL-37 expression to coordinate pro- and anti-inflammatory processes from within a single TAD. The two functionally opposed states of th

Updated on:January 26,2024

First-degree relatives have high perceived risk for rheumatoid arthritis

by Elana GotkineFirst-degree relatives (FDRs) of patients with rheumatoid arthritis (RA) have a high perceived risk for developing RA, according to a study published online Dec. 5 inRMD Open.Sar

Updated on: June 26,2024

First-degree relatives have high perceived risk for rheumatoid arthritis

by Elana GotkineFirst-degree relatives (FDRs) of patients with rheumatoid arthritis (RA) have a high perceived risk for developing RA, according to a study published online Dec. 5 inRMD Open.Sar

Updated on:June 26,2024

RNA sequencing used to discover novel genes and pathways in celiac disease

by Massachusetts General HospitalCredit: CC0 Public DomainResearchers at the Mucosal Immunology and Biology Research Center at MassGeneral Hospital for Children (MGHfC) have discovered novel gene

Updated on: April 22,2024

RNA sequencing used to discover novel genes and pathways in celiac disease

by Massachusetts General HospitalCredit: CC0 Public DomainResearchers at the Mucosal Immunology and Biology Research Center at MassGeneral Hospital for Children (MGHfC) have discovered novel gene

Updated on:April 22,2024

Time change for biological aging clocks: How immune cells shape our body's true age

by Dartmouth HealthThe association between immune cell composition and EAA for Horvath, Hannum, Pheno, and Zhang, DunedinPACE, and EpiTOC2 TNSC clocks across three age groups (0, 0–18, 18–99). Se

Updated on: March 07,2024

Time change for biological aging clocks: How immune cells shape our body's true age

by Dartmouth HealthThe association between immune cell composition and EAA for Horvath, Hannum, Pheno, and Zhang, DunedinPACE, and EpiTOC2 TNSC clocks across three age groups (0, 0–18, 18–99). Se

Updated on:March 07,2024

CAR T cell therapy could reach beyond cancer

by Perelman School of Medicine at the University of PennsylvaniaCredit: CC0 Public DomainEngineered immune cells, known as CAR T cells, have shown the world what personalized immunotherapies can

Updated on: April 09,2024

CAR T cell therapy could reach beyond cancer

by Perelman School of Medicine at the University of PennsylvaniaCredit: CC0 Public DomainEngineered immune cells, known as CAR T cells, have shown the world what personalized immunotherapies can

Updated on:April 09,2024

Screening and treating infections in AIIRD

by European Alliance of Associations for Rheumatology (EULAR)Typical screening for hepatitis B virus (HBV) status include HBsAg, anti-HBcore and anti-HBs. HBsAg-positive patients (HBV carriers) would

Updated on: May 26,2024

Screening and treating infections in AIIRD

by European Alliance of Associations for Rheumatology (EULAR)Typical screening for hepatitis B virus (HBV) status include HBsAg, anti-HBcore and anti-HBs. HBsAg-positive patients (HBV carriers) would

Updated on:May 26,2024