m6A mRNA modification potentiates Th17 functions to inflame autoimmunity

by Science China PressLoss of METTL3 in Th17 cells facilitated SOCS family RNA stability, inhibited IL-6/STAT3 mediated IL-17A and CCR5 expression, which in turn impeding Th17 cells differentiati

Updated on: April 16,2024

m6A mRNA modification potentiates Th17 functions to inflame autoimmunity

by Science China PressLoss of METTL3 in Th17 cells facilitated SOCS family RNA stability, inhibited IL-6/STAT3 mediated IL-17A and CCR5 expression, which in turn impeding Th17 cells differentiati

Updated on:April 16,2024

CRISPR screen reveals loss of genes in interferon gamma receptor signaling pathway

by Massachusetts General HospitalGlioblastoma (histology slide). Credit: Wikipedia/CC BY-SA 3.0Researchers at Massachusetts General Hospital (MGH) have discovered that the interferon gamma recept

Updated on: April 13,2024

CRISPR screen reveals loss of genes in interferon gamma receptor signaling pathway

by Massachusetts General HospitalGlioblastoma (histology slide). Credit: Wikipedia/CC BY-SA 3.0Researchers at Massachusetts General Hospital (MGH) have discovered that the interferon gamma recept

Updated on:April 13,2024

OCTAVE study reveals vaccine responses in patients with impaired immune systems

by University of GlasgowCredit: Pixabay/CC0 Public DomainThe OCTAVE study—a multi-center, UK-wide trial, led by the University of Glasgow and co-ordinated by the University of Birmingham's Ca

Updated on: April 20,2024

OCTAVE study reveals vaccine responses in patients with impaired immune systems

by University of GlasgowCredit: Pixabay/CC0 Public DomainThe OCTAVE study—a multi-center, UK-wide trial, led by the University of Glasgow and co-ordinated by the University of Birmingham's Ca

Updated on:April 20,2024

How a COVID-19 infection spurs antibodies against common colds

by The Scripps Research InstituteResearchers analyzed the structures of antibodies (colored) from healthy donors as the molecules bound to the spike protein from common coronaviruses like OC43 (s

Updated on: April 10,2024

How a COVID-19 infection spurs antibodies against common colds

by The Scripps Research InstituteResearchers analyzed the structures of antibodies (colored) from healthy donors as the molecules bound to the spike protein from common coronaviruses like OC43 (s

Updated on:April 10,2024

A new toolkit to engineer safe and efficient therapeutic cells

by Stacie Dodgson and Françoise Chanut,Gladstone InstitutesGraphical abstract. Credit:Cell(2022). DOI: 10.1016/j.cell.2022.03.023Therapies based on engineered immune cells have recen

Updated on: May 07,2024

A new toolkit to engineer safe and efficient therapeutic cells

by Stacie Dodgson and Françoise Chanut,Gladstone InstitutesGraphical abstract. Credit:Cell(2022). DOI: 10.1016/j.cell.2022.03.023Therapies based on engineered immune cells have recen

Updated on:May 07,2024

A protein's surprising role offers clues to limit graft-vs.-host disease

by Nicole Fawcett,University of MichiganFrom left, Hideaki Fujiwara, M.D., Ph.D.; Grace Chen, M.D., Ph.D.; and Pavan Reddy, M.D. Credit: University of Michigan Rogel Cancer CenterA protein that

Updated on: May 07,2024

A protein's surprising role offers clues to limit graft-vs.-host disease

by Nicole Fawcett,University of MichiganFrom left, Hideaki Fujiwara, M.D., Ph.D.; Grace Chen, M.D., Ph.D.; and Pavan Reddy, M.D. Credit: University of Michigan Rogel Cancer CenterA protein that

Updated on:May 07,2024

One step closer to tailored treatment of severe rheumatic diseases

by Aarhus UniversityThe study leads us to hope that the immunological cells and inflammatory signalling molecules in the joint of each individual patient will be able to predict the most effectiv

Updated on: June 17,2024

One step closer to tailored treatment of severe rheumatic diseases

by Aarhus UniversityThe study leads us to hope that the immunological cells and inflammatory signalling molecules in the joint of each individual patient will be able to predict the most effectiv

Updated on:June 17,2024

Researchers call for improved accessibility to specialist medical services during health care crises

by Keele UniversityCredit: Pixabay/CC0 Public DomainDelays for patients awaiting a diagnosis of an inflammatory arthritis, caused by changes in practice during the COVID pandemic, could have a ne

Updated on: May 23,2024

Researchers call for improved accessibility to specialist medical services during health care crises

by Keele UniversityCredit: Pixabay/CC0 Public DomainDelays for patients awaiting a diagnosis of an inflammatory arthritis, caused by changes in practice during the COVID pandemic, could have a ne

Updated on:May 23,2024

Rheumatoid arthritis tied to heavy economic and human burdens

by Lori SolomonRheumatoid arthritis (RA) is associated with higher health care expenditures and suboptimal quality of life in U.S. adults, according to a studypublishedonline Aug. 6 in&nbs

Updated on: October 09,2024

Rheumatoid arthritis tied to heavy economic and human burdens

by Lori SolomonRheumatoid arthritis (RA) is associated with higher health care expenditures and suboptimal quality of life in U.S. adults, according to a studypublishedonline Aug. 6 in&nbs

Updated on:October 09,2024

Drug shows promise to treat diet-induced osteoarthritis

by Queensland University of TechnologyCredit: CC0 Public DomainQUT scientists have found that a drug derived from omega-3 fatty acids can reduce osteoarthritis inflammation that's been caused

Updated on: April 17,2024

Drug shows promise to treat diet-induced osteoarthritis

by Queensland University of TechnologyCredit: CC0 Public DomainQUT scientists have found that a drug derived from omega-3 fatty acids can reduce osteoarthritis inflammation that's been caused

Updated on:April 17,2024

Risk score predicts disease progression in patients with rheumatoid arthritis

by WileyCredit: Unsplash/CC0 Public DomainScientists have created a risk score based on thousands of genetic variants to determine the prognosis of individual patients with rheumatoid arthritis.I

Updated on: June 17,2024

Risk score predicts disease progression in patients with rheumatoid arthritis

by WileyCredit: Unsplash/CC0 Public DomainScientists have created a risk score based on thousands of genetic variants to determine the prognosis of individual patients with rheumatoid arthritis.I

Updated on:June 17,2024

Study aims to unravel the genetic causes of osteoarthritis

by Wellcome Trust Sanger InstituteA hip with osteoarthritis. In an X-ray of a healthy hip, the heads of the hip bone have smooth, evenly curved surfaces and there is a 'gap' between the h

Updated on: March 28,2024

Study aims to unravel the genetic causes of osteoarthritis

by Wellcome Trust Sanger InstituteA hip with osteoarthritis. In an X-ray of a healthy hip, the heads of the hip bone have smooth, evenly curved surfaces and there is a 'gap' between the h

Updated on:March 28,2024