A new toolkit to engineer safe and efficient therapeutic cells

by Stacie Dodgson and Françoise Chanut,Gladstone InstitutesGraphical abstract. Credit:Cell(2022). DOI: 10.1016/j.cell.2022.03.023Therapies based on engineered immune cells have recen

Updated on: May 07,2024

A new toolkit to engineer safe and efficient therapeutic cells

by Stacie Dodgson and Françoise Chanut,Gladstone InstitutesGraphical abstract. Credit:Cell(2022). DOI: 10.1016/j.cell.2022.03.023Therapies based on engineered immune cells have recen

Updated on:May 07,2024

Low back pain? Don't blame the weather

by WileyCloud in Nepali sky. Credit: WikipediaAustralian researchers reveal that sudden, acute episodes of low back pain are not linked to weather conditions such as temperature, humidity, air pr

Updated on: March 24,2024

Low back pain? Don't blame the weather

by WileyCloud in Nepali sky. Credit: WikipediaAustralian researchers reveal that sudden, acute episodes of low back pain are not linked to weather conditions such as temperature, humidity, air pr

Updated on:March 24,2024

T cells: Vesicles strengthen immune response

by Ludwig Maximilian University of MunichMFG-E8-eGFP detects PS+ apoptotic and PS+ EV-decorated cells in vivo. Credit: Proceedings of the National Academy of Sciences (2023). DOI: 10.1073/pnas.22

Updated on: May 05,2024

T cells: Vesicles strengthen immune response

by Ludwig Maximilian University of MunichMFG-E8-eGFP detects PS+ apoptotic and PS+ EV-decorated cells in vivo. Credit: Proceedings of the National Academy of Sciences (2023). DOI: 10.1073/pnas.22

Updated on:May 05,2024

Research unveils metabolic strategies to enhance CAR-T cell therapy

by Cactus CommunicationsChimeric antigen receptor T (CAR-T) cell therapy effectively treats hematological tumors but struggles due to metabolic challenges in the tumor microenvironment. Tumor cells di

Updated on: March 27,2024

Research unveils metabolic strategies to enhance CAR-T cell therapy

by Cactus CommunicationsChimeric antigen receptor T (CAR-T) cell therapy effectively treats hematological tumors but struggles due to metabolic challenges in the tumor microenvironment. Tumor cells di

Updated on:March 27,2024

CRISPR screen reveals loss of genes in interferon gamma receptor signaling pathway

by Massachusetts General HospitalGlioblastoma (histology slide). Credit: Wikipedia/CC BY-SA 3.0Researchers at Massachusetts General Hospital (MGH) have discovered that the interferon gamma recept

Updated on: April 13,2024

CRISPR screen reveals loss of genes in interferon gamma receptor signaling pathway

by Massachusetts General HospitalGlioblastoma (histology slide). Credit: Wikipedia/CC BY-SA 3.0Researchers at Massachusetts General Hospital (MGH) have discovered that the interferon gamma recept

Updated on:April 13,2024

Scientists create first mouse model with complete, functional human immune system

byUniversity of Texas Health Science Center at San AntonioLeft, malar rash in a (huNSGW41-derived) Lupus THX mouse (three weeks after pristane injection). Middle, serum antinuclear IgGs (scale b

Updated on: July 09,2024

Scientists create first mouse model with complete, functional human immune system

byUniversity of Texas Health Science Center at San AntonioLeft, malar rash in a (huNSGW41-derived) Lupus THX mouse (three weeks after pristane injection). Middle, serum antinuclear IgGs (scale b

Updated on:July 09,2024

Could painkillers be hiding serious arthritis condition from doctors?

by Euan Wemyss,University of AberdeenCould anti-inflammatory drugs be masking serious arthritis condition, University of Aberdeen to explore. Credit: University of AberdeenThousands of patients

Updated on: March 24,2024

Could painkillers be hiding serious arthritis condition from doctors?

by Euan Wemyss,University of AberdeenCould anti-inflammatory drugs be masking serious arthritis condition, University of Aberdeen to explore. Credit: University of AberdeenThousands of patients

Updated on:March 24,2024

Uncovering the cause of regulatory T cell dysfunction in elderly-onset rheumatoid arthritis

byUniversity of TsukubaGraphical abstract. Credit:Clinical Immunology(2024). DOI: 10.1016/j.clim.2024.110337Researchers at Tsukuba University have discovered that the increase in reg

Updated on: September 02,2024

Uncovering the cause of regulatory T cell dysfunction in elderly-onset rheumatoid arthritis

byUniversity of TsukubaGraphical abstract. Credit:Clinical Immunology(2024). DOI: 10.1016/j.clim.2024.110337Researchers at Tsukuba University have discovered that the increase in reg

Updated on:September 02,2024

CVD risk factors tied to disease activity, disability in RA

(HealthDay)—Cardiovascular disease (CVD) risk factors alone, or in combination, are associated with higher disease activity and disability in rheumatoid arthritis (RA), according to a study recently p

Updated on: June 01,2024

CVD risk factors tied to disease activity, disability in RA

(HealthDay)—Cardiovascular disease (CVD) risk factors alone, or in combination, are associated with higher disease activity and disability in rheumatoid arthritis (RA), according to a study recently p

Updated on:June 01,2024

Study finds COVID-19 vaccine not associated with severe disease flare in patients with rheumatic diseases

by American College of RheumatologyCredit: Unsplash/CC0 Public DomainNew research presented this week at ACR Convergence, the American College of Rheumatology's annual meeting, shows that the

Updated on: June 17,2024

Study finds COVID-19 vaccine not associated with severe disease flare in patients with rheumatic diseases

by American College of RheumatologyCredit: Unsplash/CC0 Public DomainNew research presented this week at ACR Convergence, the American College of Rheumatology's annual meeting, shows that the

Updated on:June 17,2024

The 'greying' of T cells: Scientists pinpoint metabolic pathway behind age-related immunity loss

by Harvard Medical SchoolCredit: CC0 Public DomainThe elderly suffer more serious complications from infections and benefit less from vaccination than the general population. Scientists have long

Updated on: May 06,2024

The 'greying' of T cells: Scientists pinpoint metabolic pathway behind age-related immunity loss

by Harvard Medical SchoolCredit: CC0 Public DomainThe elderly suffer more serious complications from infections and benefit less from vaccination than the general population. Scientists have long

Updated on:May 06,2024

Does an elevated immune response to a gut bacterial protein contribute to rheumatoid arthritis?

by WileyCredit: Unsplash/CC0 Public DomainRheumatoid arthritis is a chronic autoimmune disease that is associated with aberrant immune responses. In a recent analysis published inArthritis

Updated on: June 15,2024

Does an elevated immune response to a gut bacterial protein contribute to rheumatoid arthritis?

by WileyCredit: Unsplash/CC0 Public DomainRheumatoid arthritis is a chronic autoimmune disease that is associated with aberrant immune responses. In a recent analysis published inArthritis

Updated on:June 15,2024