Researchers redesign future mRNA therapeutics to prevent potentially harmful immune responses

byUniversity of CambridgeBiochemist Professor Anne Willis and immunologist Dr James Thaventhiran at the MRC Toxicology Unit at the University of Cambridge led this work. Credit: Mike Thornton, S

Updated on: January 26,2024

Researchers redesign future mRNA therapeutics to prevent potentially harmful immune responses

byUniversity of CambridgeBiochemist Professor Anne Willis and immunologist Dr James Thaventhiran at the MRC Toxicology Unit at the University of Cambridge led this work. Credit: Mike Thornton, S

Updated on:January 26,2024

Researchers identify new way to inhibit immune cells that drive allergic asthma

by Rockefeller University PressActivation of ILC2s causes inflammation in mouse lungs (left), but this is reduced by treatment with Yoda1 to stimulate Piezo1 channels (right). Credit:(2024)

Updated on: April 06,2024

Researchers identify new way to inhibit immune cells that drive allergic asthma

by Rockefeller University PressActivation of ILC2s causes inflammation in mouse lungs (left), but this is reduced by treatment with Yoda1 to stimulate Piezo1 channels (right). Credit:(2024)

Updated on:April 06,2024

ATP from sensory neuron-interneuron crosstalk is key to spreading inflammation in rheumatoid arthritis

by Hokkaido UniversityThe inflammation signal (IL-6 amplifier) in the affected joint (L) causes the secretion of ATP that transmits a signal through the spinal cord (DRG, L5), which in turn trigg

Updated on: June 06,2024

ATP from sensory neuron-interneuron crosstalk is key to spreading inflammation in rheumatoid arthritis

by Hokkaido UniversityThe inflammation signal (IL-6 amplifier) in the affected joint (L) causes the secretion of ATP that transmits a signal through the spinal cord (DRG, L5), which in turn trigg

Updated on:June 06,2024

Hope for treating autoimmune diseases: Researchers explore diagnostic role of the systemic inflammation index

by Flinders UniversityCredit: Unsplash/CC0 Public DomainA routine blood test that measures a patient's inflammation levels could improve the early diagnosis and management of a wide range of

Updated on: April 06,2024

Hope for treating autoimmune diseases: Researchers explore diagnostic role of the systemic inflammation index

by Flinders UniversityCredit: Unsplash/CC0 Public DomainA routine blood test that measures a patient's inflammation levels could improve the early diagnosis and management of a wide range of

Updated on:April 06,2024

Systemic inflammation increases risk for chronic kidney disease

by Lori SolomonSystemic inflammation is associated with an elevated risk for chronic kidney disease, according to a study published online Feb. 20 inFrontiers in Immunology.Xiaoxin Liu, from Ton

Updated on: April 30,2024

Systemic inflammation increases risk for chronic kidney disease

by Lori SolomonSystemic inflammation is associated with an elevated risk for chronic kidney disease, according to a study published online Feb. 20 inFrontiers in Immunology.Xiaoxin Liu, from Ton

Updated on:April 30,2024

Disease control, safe medications critical to pregnancies for women with rheumatic disease

by UT Southwestern Medical CenterCredit: Pixabay/CC0 Public DomainPregnant women with active rheumatic disease carry a higher risk of adverse outcomes than the general population including hypert

Updated on: June 17,2024

Disease control, safe medications critical to pregnancies for women with rheumatic disease

by UT Southwestern Medical CenterCredit: Pixabay/CC0 Public DomainPregnant women with active rheumatic disease carry a higher risk of adverse outcomes than the general population including hypert

Updated on:June 17,2024

Time change for biological aging clocks: How immune cells shape our body's true age

by Dartmouth HealthThe association between immune cell composition and EAA for Horvath, Hannum, Pheno, and Zhang, DunedinPACE, and EpiTOC2 TNSC clocks across three age groups (0, 0–18, 18–99). Se

Updated on: March 07,2024

Time change for biological aging clocks: How immune cells shape our body's true age

by Dartmouth HealthThe association between immune cell composition and EAA for Horvath, Hannum, Pheno, and Zhang, DunedinPACE, and EpiTOC2 TNSC clocks across three age groups (0, 0–18, 18–99). Se

Updated on:March 07,2024

Screening and treating infections in AIIRD

by European Alliance of Associations for Rheumatology (EULAR)Typical screening for hepatitis B virus (HBV) status include HBsAg, anti-HBcore and anti-HBs. HBsAg-positive patients (HBV carriers) would

Updated on: May 26,2024

Screening and treating infections in AIIRD

by European Alliance of Associations for Rheumatology (EULAR)Typical screening for hepatitis B virus (HBV) status include HBsAg, anti-HBcore and anti-HBs. HBsAg-positive patients (HBV carriers) would

Updated on:May 26,2024

Updated: AAV treatment recommendations

by European Alliance of Associations for Rheumatology (EULAR)The 2022 EULAR algorithm for treatment of granulomatosis with polyangiitis (GPA) or microscopic polyangiitis (MPA). Dashed lines indicate s

Updated on: June 15,2024

Updated: AAV treatment recommendations

by European Alliance of Associations for Rheumatology (EULAR)The 2022 EULAR algorithm for treatment of granulomatosis with polyangiitis (GPA) or microscopic polyangiitis (MPA). Dashed lines indicate s

Updated on:June 15,2024

Study finds cycling JAK inhibitors to be an effective option for patients with difficult-to-treat rheumatoid arthritis

by American College of RheumatologyCredit: Unsplash/CC0 Public DomainNew research presented this week at ACR Convergence, the American College of Rheumatology's annual meeting, shows that peo

Updated on: May 29,2024

Study finds cycling JAK inhibitors to be an effective option for patients with difficult-to-treat rheumatoid arthritis

by American College of RheumatologyCredit: Unsplash/CC0 Public DomainNew research presented this week at ACR Convergence, the American College of Rheumatology's annual meeting, shows that peo

Updated on:May 29,2024

Gut microbiome: Meet Roseburia intestinalis—the energy-producing bacterium that helps us fight against disease

by Conor Meehan,The ConversationCredit: Pixabay/CC0 Public DomainThe hundreds of species of microorganisms that comprise the microbiome all have different, unique roles.One of the important func

Updated on: March 27,2024

Gut microbiome: Meet Roseburia intestinalis—the energy-producing bacterium that helps us fight against disease

by Conor Meehan,The ConversationCredit: Pixabay/CC0 Public DomainThe hundreds of species of microorganisms that comprise the microbiome all have different, unique roles.One of the important func

Updated on:March 27,2024

C-reactive protein reduces the immune response in inflammatory disease

by Karin Söderlund Leifler,Linköping UniversityGraphical abstract. Credit:Journal of Autoimmunity(2023). DOI: 10.1016/j.jaut.2023.102998The biological function of the C-reactive prot

Updated on: April 13,2024

C-reactive protein reduces the immune response in inflammatory disease

by Karin Söderlund Leifler,Linköping UniversityGraphical abstract. Credit:Journal of Autoimmunity(2023). DOI: 10.1016/j.jaut.2023.102998The biological function of the C-reactive prot

Updated on:April 13,2024