Mettl3-dependent m6A modification is essential for effector differentiation and memory formation of CD8+ T cells

byScience China PressDuring viral infection, total m6A levels in Naïve stage, effector stage, and memory stage exhibit dynamic alteration (high-low-high). The presence of Mettl3 promotes CD8 T c

Updated on: January 26,2024 19

Mettl3-dependent m6A modification is essential for effector differentiation and memory formation of CD8+ T cells

byScience China PressDuring viral infection, total m6A levels in Naïve stage, effector stage, and memory stage exhibit dynamic alteration (high-low-high). The presence of Mettl3 promotes CD8 T c

Updated on:January 26,2024 19

New method is better able to map immune response and paves way for new treatments

byKarolinska InstitutetSpatial transcriptomics–based method to map B cell and T cell receptors.Targeted capture of antigen receptor sequences from spatial transcriptomics gene expression librari

Updated on: January 26,2024 17

New method is better able to map immune response and paves way for new treatments

byKarolinska InstitutetSpatial transcriptomics–based method to map B cell and T cell receptors.Targeted capture of antigen receptor sequences from spatial transcriptomics gene expression librari

Updated on:January 26,2024 17

RNA proofreading mistakes drive group of autoimmune diseases

by The Scripps Research InstituteScripps Research Professor Patrick Griffin, PhD, of Jupiter, Florida, co-chairman of the Department of Molecular Medicine, used hydrogen-deuterium exchange mass s

Updated on: April 22,2024 14

RNA proofreading mistakes drive group of autoimmune diseases

by The Scripps Research InstituteScripps Research Professor Patrick Griffin, PhD, of Jupiter, Florida, co-chairman of the Department of Molecular Medicine, used hydrogen-deuterium exchange mass s

Updated on:April 22,2024 14

Researchers find genetic association for interstitial lung disease

by University of TsukubaMUC5B risk allele carrier frequency in ANCA-associated vasculitis (AAV) with and without interstitial lung disease (ILD) as well as in healthy controls in the Japanese pop

Updated on: May 19,2024 3

Researchers find genetic association for interstitial lung disease

by University of TsukubaMUC5B risk allele carrier frequency in ANCA-associated vasculitis (AAV) with and without interstitial lung disease (ILD) as well as in healthy controls in the Japanese pop

Updated on:May 19,2024 3

Better than a pill: Team to develop new arthritis treatment via silk

by Erika Ebsworth-Goold,Washington University School of Medicine in St. LouisA team of researchers from Washington University in St. Louis will use silk micro-particles, like the ones pictured h

Updated on: June 26,2024 8

Better than a pill: Team to develop new arthritis treatment via silk

by Erika Ebsworth-Goold,Washington University School of Medicine in St. LouisA team of researchers from Washington University in St. Louis will use silk micro-particles, like the ones pictured h

Updated on:June 26,2024 8

Mortality rate up for Koreans with rheumatoid arthritis

(HealthDay)—Korean patients with rheumatoid arthritis (RA) have increased mortality rates compared with the general population, according to a study published online Jan. 19 in theInternational

Updated on: May 08,2024 6

Mortality rate up for Koreans with rheumatoid arthritis

(HealthDay)—Korean patients with rheumatoid arthritis (RA) have increased mortality rates compared with the general population, according to a study published online Jan. 19 in theInternational

Updated on:May 08,2024 6

The PANoptosome: A new frontier in innate immune responses

by St. Jude Children's Research HospitalCredit: CC0 Public DomainSt. Jude Children's Research Hospital immunologists have identified how immune sensors in infected cells organize and laun

Updated on: April 20,2024 20

The PANoptosome: A new frontier in innate immune responses

by St. Jude Children's Research HospitalCredit: CC0 Public DomainSt. Jude Children's Research Hospital immunologists have identified how immune sensors in infected cells organize and laun

Updated on:April 20,2024 20

Review discusses metabolic reprogramming of T cells

by Cactus CommunicationsT cell immunotherapy can be optimized by understanding the metabolism of T cells. This review article summarizes the intricacies of effector and memory T cell metabolic reprogr

Updated on: March 07,2024 12

Review discusses metabolic reprogramming of T cells

by Cactus CommunicationsT cell immunotherapy can be optimized by understanding the metabolism of T cells. This review article summarizes the intricacies of effector and memory T cell metabolic reprogr

Updated on:March 07,2024 12

ATP from sensory neuron-interneuron crosstalk is key to spreading inflammation in rheumatoid arthritis

by Hokkaido UniversityThe inflammation signal (IL-6 amplifier) in the affected joint (L) causes the secretion of ATP that transmits a signal through the spinal cord (DRG, L5), which in turn trigg

Updated on: June 06,2024 4

ATP from sensory neuron-interneuron crosstalk is key to spreading inflammation in rheumatoid arthritis

by Hokkaido UniversityThe inflammation signal (IL-6 amplifier) in the affected joint (L) causes the secretion of ATP that transmits a signal through the spinal cord (DRG, L5), which in turn trigg

Updated on:June 06,2024 4

Women who are 'larks' have a lower risk of developing breast cancer

by National Cancer Research InstituteThree-dimensional culture of human breast cancer cells, with DNA stained blue and a protein in the cell surface membrane stained green. Image created in 2014 by To

Updated on: March 13,2024 19

Women who are 'larks' have a lower risk of developing breast cancer

by National Cancer Research InstituteThree-dimensional culture of human breast cancer cells, with DNA stained blue and a protein in the cell surface membrane stained green. Image created in 2014 by To

Updated on:March 13,2024 19

Smoking cessation may reduce risk of rheumatoid arthritis

by Brigham and Women's HospitalCredit: CC0 Public DomainSmoking is an important risk factor for developing the most common form of rheumatoid arthritis (RA) and other inflammatory diseases, b

Updated on: May 13,2024 7

Smoking cessation may reduce risk of rheumatoid arthritis

by Brigham and Women's HospitalCredit: CC0 Public DomainSmoking is an important risk factor for developing the most common form of rheumatoid arthritis (RA) and other inflammatory diseases, b

Updated on:May 13,2024 7

Study links lower hydroxychloroquine dose to more hospitalizations for systemic lupus erythematosus flares

by American College of RheumatologyCase-Crossover Study Design: In this case-crossover study, case periods were the 6-months prior to a hospitalization for SLE flare. Control periods were 6-month

Updated on: June 01,2024 3

Study links lower hydroxychloroquine dose to more hospitalizations for systemic lupus erythematosus flares

by American College of RheumatologyCase-Crossover Study Design: In this case-crossover study, case periods were the 6-months prior to a hospitalization for SLE flare. Control periods were 6-month

Updated on:June 01,2024 3