New drug expands treatment opportunities for rheumatoid arthritis

by Medical University of ViennaCredit: Unsplash/CC0 Public DomainIn its final Phase III clinical trial, a new drug for treating rheumatoid arthritis has proved to be at least as effective as the

Updated on: June 26,2024

New drug expands treatment opportunities for rheumatoid arthritis

by Medical University of ViennaCredit: Unsplash/CC0 Public DomainIn its final Phase III clinical trial, a new drug for treating rheumatoid arthritis has proved to be at least as effective as the

Updated on:June 26,2024

An experimental vaccine against rheumatoid arthritis

by University of ToledoCredit: CC0 Public DomainResearchers at The University of Toledo have developed an experimental vaccine that shows significant promise in preventing rheumatoid arthritis, a

Updated on: June 28,2024

An experimental vaccine against rheumatoid arthritis

by University of ToledoCredit: CC0 Public DomainResearchers at The University of Toledo have developed an experimental vaccine that shows significant promise in preventing rheumatoid arthritis, a

Updated on:June 28,2024

ATP from sensory neuron-interneuron crosstalk is key to spreading inflammation in rheumatoid arthritis

by Hokkaido UniversityThe inflammation signal (IL-6 amplifier) in the affected joint (L) causes the secretion of ATP that transmits a signal through the spinal cord (DRG, L5), which in turn trigg

Updated on: June 06,2024

ATP from sensory neuron-interneuron crosstalk is key to spreading inflammation in rheumatoid arthritis

by Hokkaido UniversityThe inflammation signal (IL-6 amplifier) in the affected joint (L) causes the secretion of ATP that transmits a signal through the spinal cord (DRG, L5), which in turn trigg

Updated on:June 06,2024

Sleep deprivation may increase risk for systemic lupus in women

Lack of sleep is associated with an increased risk for systemic lupus erythematosus (SLE), particularly among women with concomitant depression or bodily pain, according to a study published online Se

Updated on: May 26,2024

Sleep deprivation may increase risk for systemic lupus in women

Lack of sleep is associated with an increased risk for systemic lupus erythematosus (SLE), particularly among women with concomitant depression or bodily pain, according to a study published online Se

Updated on:May 26,2024

Mettl3-dependent m6A modification is essential for effector differentiation and memory formation of CD8+ T cells

byScience China PressDuring viral infection, total m6A levels in Naïve stage, effector stage, and memory stage exhibit dynamic alteration (high-low-high). The presence of Mettl3 promotes CD8 T c

Updated on: January 26,2024

Mettl3-dependent m6A modification is essential for effector differentiation and memory formation of CD8+ T cells

byScience China PressDuring viral infection, total m6A levels in Naïve stage, effector stage, and memory stage exhibit dynamic alteration (high-low-high). The presence of Mettl3 promotes CD8 T c

Updated on:January 26,2024

Mayo Clinic Q and A: Springtime allergies

by Cynthia WeissCredit: CC0 Public DomainDEAR MAYO CLINIC: I love the changing seasons and am looking forward to the warmer days of spring. Unfortunately, I am often miserable because of seasonal alle

Updated on: March 04,2024

Mayo Clinic Q and A: Springtime allergies

by Cynthia WeissCredit: CC0 Public DomainDEAR MAYO CLINIC: I love the changing seasons and am looking forward to the warmer days of spring. Unfortunately, I am often miserable because of seasonal alle

Updated on:March 04,2024

Once considered rare, an itchy dermatologic skin disorder is more common than thought

by Johns Hopkins UniversityCredit: CC0 Public DomainJohns Hopkins researchers report that prurigo nodularis (PN), a skin disease characterized by severely itchy, firm bumps on the skin, may be as

Updated on: April 24,2024

Once considered rare, an itchy dermatologic skin disorder is more common than thought

by Johns Hopkins UniversityCredit: CC0 Public DomainJohns Hopkins researchers report that prurigo nodularis (PN), a skin disease characterized by severely itchy, firm bumps on the skin, may be as

Updated on:April 24,2024

How a pregnant woman who smokes can be hurting her future grandchildren

by Ileana Varela,Florida International UniversityCredit: CC0 Public DomainThe dangers of smoking are common knowledge. Smoking during pregnancy, even second-hand smoke, can hurt both the mother

Updated on: April 24,2024

How a pregnant woman who smokes can be hurting her future grandchildren

by Ileana Varela,Florida International UniversityCredit: CC0 Public DomainThe dangers of smoking are common knowledge. Smoking during pregnancy, even second-hand smoke, can hurt both the mother

Updated on:April 24,2024

How an immune response is driven by one letter difference in DNA

byRadboud UniversityA biphasic circuit regulates IL-1β and IL-37 expression to coordinate pro- and anti-inflammatory processes from within a single TAD. The two functionally opposed states of th

Updated on: January 26,2024

How an immune response is driven by one letter difference in DNA

byRadboud UniversityA biphasic circuit regulates IL-1β and IL-37 expression to coordinate pro- and anti-inflammatory processes from within a single TAD. The two functionally opposed states of th

Updated on:January 26,2024

Updated: AAV treatment recommendations

by European Alliance of Associations for Rheumatology (EULAR)The 2022 EULAR algorithm for treatment of granulomatosis with polyangiitis (GPA) or microscopic polyangiitis (MPA). Dashed lines indicate s

Updated on: June 15,2024

Updated: AAV treatment recommendations

by European Alliance of Associations for Rheumatology (EULAR)The 2022 EULAR algorithm for treatment of granulomatosis with polyangiitis (GPA) or microscopic polyangiitis (MPA). Dashed lines indicate s

Updated on:June 15,2024

CARv3-TEAM-E T-cell treatment beneficial for recurrent glioblastoma

by Elana GotkineFor patients with recurrent glioblastoma, treatment with chimeric antigen receptor (CAR) T-cells engineered to target the epidermal growth factor receptor (EGFR) variant III tumor-spec

Updated on: March 27,2024

CARv3-TEAM-E T-cell treatment beneficial for recurrent glioblastoma

by Elana GotkineFor patients with recurrent glioblastoma, treatment with chimeric antigen receptor (CAR) T-cells engineered to target the epidermal growth factor receptor (EGFR) variant III tumor-spec

Updated on:March 27,2024

Researchers redesign future mRNA therapeutics to prevent potentially harmful immune responses

byUniversity of CambridgeBiochemist Professor Anne Willis and immunologist Dr James Thaventhiran at the MRC Toxicology Unit at the University of Cambridge led this work. Credit: Mike Thornton, S

Updated on: January 26,2024

Researchers redesign future mRNA therapeutics to prevent potentially harmful immune responses

byUniversity of CambridgeBiochemist Professor Anne Willis and immunologist Dr James Thaventhiran at the MRC Toxicology Unit at the University of Cambridge led this work. Credit: Mike Thornton, S

Updated on:January 26,2024