RNA proofreading mistakes drive group of autoimmune diseases

by The Scripps Research InstituteScripps Research Professor Patrick Griffin, PhD, of Jupiter, Florida, co-chairman of the Department of Molecular Medicine, used hydrogen-deuterium exchange mass s

Updated on: April 22,2024 14

RNA proofreading mistakes drive group of autoimmune diseases

by The Scripps Research InstituteScripps Research Professor Patrick Griffin, PhD, of Jupiter, Florida, co-chairman of the Department of Molecular Medicine, used hydrogen-deuterium exchange mass s

Updated on:April 22,2024 14

Mettl3-dependent m6A modification is essential for effector differentiation and memory formation of CD8+ T cells

byScience China PressDuring viral infection, total m6A levels in Naïve stage, effector stage, and memory stage exhibit dynamic alteration (high-low-high). The presence of Mettl3 promotes CD8 T c

Updated on: January 26,2024 19

Mettl3-dependent m6A modification is essential for effector differentiation and memory formation of CD8+ T cells

byScience China PressDuring viral infection, total m6A levels in Naïve stage, effector stage, and memory stage exhibit dynamic alteration (high-low-high). The presence of Mettl3 promotes CD8 T c

Updated on:January 26,2024 19

CAR T cell therapies may lead to reactivation of childhood viral infections

by Justin Jackson , Medical XpressPetabase-scale analysis of viral nucleic acids reveals that HHV-6 is reactivated in human T cells. a, Schematic of life cycles of endogenous human viruses. Viruses ca

Updated on: April 09,2024 10

CAR T cell therapies may lead to reactivation of childhood viral infections

by Justin Jackson , Medical XpressPetabase-scale analysis of viral nucleic acids reveals that HHV-6 is reactivated in human T cells. a, Schematic of life cycles of endogenous human viruses. Viruses ca

Updated on:April 09,2024 10

Researchers find genetic association for interstitial lung disease

by University of TsukubaMUC5B risk allele carrier frequency in ANCA-associated vasculitis (AAV) with and without interstitial lung disease (ILD) as well as in healthy controls in the Japanese pop

Updated on: May 19,2024 3

Researchers find genetic association for interstitial lung disease

by University of TsukubaMUC5B risk allele carrier frequency in ANCA-associated vasculitis (AAV) with and without interstitial lung disease (ILD) as well as in healthy controls in the Japanese pop

Updated on:May 19,2024 3

Lasting impact of COVID-19 infection on the immune system

by Elisa Black,University of AdelaideCredit: Unsplash/CC0 Public DomainA world leading research collaboration between SAHMRI, the University of Adelaide, Flinders University, the Women's and

Updated on: April 10,2024 14

Lasting impact of COVID-19 infection on the immune system

by Elisa Black,University of AdelaideCredit: Unsplash/CC0 Public DomainA world leading research collaboration between SAHMRI, the University of Adelaide, Flinders University, the Women's and

Updated on:April 10,2024 14

Review discusses metabolic reprogramming of T cells

by Cactus CommunicationsT cell immunotherapy can be optimized by understanding the metabolism of T cells. This review article summarizes the intricacies of effector and memory T cell metabolic reprogr

Updated on: March 07,2024 12

Review discusses metabolic reprogramming of T cells

by Cactus CommunicationsT cell immunotherapy can be optimized by understanding the metabolism of T cells. This review article summarizes the intricacies of effector and memory T cell metabolic reprogr

Updated on:March 07,2024 12

Passive smoking linked to increased risk of rheumatoid arthritis

Passive smoking during childhood and/or adulthood is associated with increased risk of rheumatoid arthritis (RA), according to a study recently published inRMD Open.Yann Nguyen, M.D., M.P.H., fr

Updated on: June 06,2024 6

Passive smoking linked to increased risk of rheumatoid arthritis

Passive smoking during childhood and/or adulthood is associated with increased risk of rheumatoid arthritis (RA), according to a study recently published inRMD Open.Yann Nguyen, M.D., M.P.H., fr

Updated on:June 06,2024 6

Smoking cessation may reduce risk of rheumatoid arthritis

by Brigham and Women's HospitalCredit: CC0 Public DomainSmoking is an important risk factor for developing the most common form of rheumatoid arthritis (RA) and other inflammatory diseases, b

Updated on: May 13,2024 7

Smoking cessation may reduce risk of rheumatoid arthritis

by Brigham and Women's HospitalCredit: CC0 Public DomainSmoking is an important risk factor for developing the most common form of rheumatoid arthritis (RA) and other inflammatory diseases, b

Updated on:May 13,2024 7

ATP from sensory neuron-interneuron crosstalk is key to spreading inflammation in rheumatoid arthritis

by Hokkaido UniversityThe inflammation signal (IL-6 amplifier) in the affected joint (L) causes the secretion of ATP that transmits a signal through the spinal cord (DRG, L5), which in turn trigg

Updated on: June 06,2024 4

ATP from sensory neuron-interneuron crosstalk is key to spreading inflammation in rheumatoid arthritis

by Hokkaido UniversityThe inflammation signal (IL-6 amplifier) in the affected joint (L) causes the secretion of ATP that transmits a signal through the spinal cord (DRG, L5), which in turn trigg

Updated on:June 06,2024 4

Women who are 'larks' have a lower risk of developing breast cancer

by National Cancer Research InstituteThree-dimensional culture of human breast cancer cells, with DNA stained blue and a protein in the cell surface membrane stained green. Image created in 2014 by To

Updated on: March 13,2024 19

Women who are 'larks' have a lower risk of developing breast cancer

by National Cancer Research InstituteThree-dimensional culture of human breast cancer cells, with DNA stained blue and a protein in the cell surface membrane stained green. Image created in 2014 by To

Updated on:March 13,2024 19

Study links lower hydroxychloroquine dose to more hospitalizations for systemic lupus erythematosus flares

by American College of RheumatologyCase-Crossover Study Design: In this case-crossover study, case periods were the 6-months prior to a hospitalization for SLE flare. Control periods were 6-month

Updated on: June 01,2024 3

Study links lower hydroxychloroquine dose to more hospitalizations for systemic lupus erythematosus flares

by American College of RheumatologyCase-Crossover Study Design: In this case-crossover study, case periods were the 6-months prior to a hospitalization for SLE flare. Control periods were 6-month

Updated on:June 01,2024 3

Renal macrophages observed playing crucial role in preventing kidney stones

by Justin Jackson , Medical XpressGraphical abstract. Credit:Immunity(2023). DOI: 10.1016/j.immuni.2023.12.003Researchers at Zhejiang University School of Medicine, China, have investigate

Updated on: March 07,2024 19

Renal macrophages observed playing crucial role in preventing kidney stones

by Justin Jackson , Medical XpressGraphical abstract. Credit:Immunity(2023). DOI: 10.1016/j.immuni.2023.12.003Researchers at Zhejiang University School of Medicine, China, have investigate

Updated on:March 07,2024 19