ATP from sensory neuron-interneuron crosstalk is key to spreading inflammation in rheumatoid arthritis

by Hokkaido UniversityThe inflammation signal (IL-6 amplifier) in the affected joint (L) causes the secretion of ATP that transmits a signal through the spinal cord (DRG, L5), which in turn trigg

Updated on: June 06,2024

ATP from sensory neuron-interneuron crosstalk is key to spreading inflammation in rheumatoid arthritis

by Hokkaido UniversityThe inflammation signal (IL-6 amplifier) in the affected joint (L) causes the secretion of ATP that transmits a signal through the spinal cord (DRG, L5), which in turn trigg

Updated on:June 06,2024

COVID-19 case severity: How genetic differences leave immune cells at a disadvantage

by La Jolla Institute for ImmunologyGenetic differences leave immune cells at a disadvantage. Credit: La Jolla Institute for ImmunologyNew research shows how genetic variations linked to severe c

Updated on: April 10,2024

COVID-19 case severity: How genetic differences leave immune cells at a disadvantage

by La Jolla Institute for ImmunologyGenetic differences leave immune cells at a disadvantage. Credit: La Jolla Institute for ImmunologyNew research shows how genetic variations linked to severe c

Updated on:April 10,2024

COVID-19 can trigger auto-immune disorders-related antibodies, causing thrombosis and other complications

by Maria Fernanda Ziegler,FAPESPThe systems immunology approach identifies an aging effect on autoantibody levels of COVID-19 patients. Credit:npj Aging(2023). DOI: 10.1038/s41514-02

Updated on: April 10,2024

COVID-19 can trigger auto-immune disorders-related antibodies, causing thrombosis and other complications

by Maria Fernanda Ziegler,FAPESPThe systems immunology approach identifies an aging effect on autoantibody levels of COVID-19 patients. Credit:npj Aging(2023). DOI: 10.1038/s41514-02

Updated on:April 10,2024

C-reactive protein reduces the immune response in inflammatory disease

by Karin Söderlund Leifler,Linköping UniversityGraphical abstract. Credit:Journal of Autoimmunity(2023). DOI: 10.1016/j.jaut.2023.102998The biological function of the C-reactive prot

Updated on: April 13,2024

C-reactive protein reduces the immune response in inflammatory disease

by Karin Söderlund Leifler,Linköping UniversityGraphical abstract. Credit:Journal of Autoimmunity(2023). DOI: 10.1016/j.jaut.2023.102998The biological function of the C-reactive prot

Updated on:April 13,2024

Consensus statement issued on management of foot, ankle gout

(HealthDay)—The American College of Foot and Ankle Surgeons and the American Association of Nurse Practitioners-Orthopedics Specialty Practice Group have issued a new joint clinical consensus statemen

Updated on: April 20,2024

Consensus statement issued on management of foot, ankle gout

(HealthDay)—The American College of Foot and Ankle Surgeons and the American Association of Nurse Practitioners-Orthopedics Specialty Practice Group have issued a new joint clinical consensus statemen

Updated on:April 20,2024

Researchers redesign future mRNA therapeutics to prevent potentially harmful immune responses

byUniversity of CambridgeBiochemist Professor Anne Willis and immunologist Dr James Thaventhiran at the MRC Toxicology Unit at the University of Cambridge led this work. Credit: Mike Thornton, S

Updated on: January 26,2024

Researchers redesign future mRNA therapeutics to prevent potentially harmful immune responses

byUniversity of CambridgeBiochemist Professor Anne Willis and immunologist Dr James Thaventhiran at the MRC Toxicology Unit at the University of Cambridge led this work. Credit: Mike Thornton, S

Updated on:January 26,2024

Researchers identify new way to inhibit immune cells that drive allergic asthma

by Rockefeller University PressActivation of ILC2s causes inflammation in mouse lungs (left), but this is reduced by treatment with Yoda1 to stimulate Piezo1 channels (right). Credit:(2024)

Updated on: April 06,2024

Researchers identify new way to inhibit immune cells that drive allergic asthma

by Rockefeller University PressActivation of ILC2s causes inflammation in mouse lungs (left), but this is reduced by treatment with Yoda1 to stimulate Piezo1 channels (right). Credit:(2024)

Updated on:April 06,2024

An asthma vaccine effective in mice

by Pasteur InstituteCredit: CC0 Public DomainInserm teams led by Laurent Reber (Infinity, Toulouse) and Pierre Bruhns (Humoral Immunity, Institut Pasteur, Paris) and French company NEOVACS have d

Updated on: April 24,2024

An asthma vaccine effective in mice

by Pasteur InstituteCredit: CC0 Public DomainInserm teams led by Laurent Reber (Infinity, Toulouse) and Pierre Bruhns (Humoral Immunity, Institut Pasteur, Paris) and French company NEOVACS have d

Updated on:April 24,2024

Phosphorylation of Regnase-1 lets IL-17 run amok

by Osaka UniversityCredit: CC0 Public DomainWhen considering the role of the key immune molecule interleukin (IL)-17, the phrase "too much of a good thing" springs to mind. Because unli

Updated on: April 22,2024

Phosphorylation of Regnase-1 lets IL-17 run amok

by Osaka UniversityCredit: CC0 Public DomainWhen considering the role of the key immune molecule interleukin (IL)-17, the phrase "too much of a good thing" springs to mind. Because unli

Updated on:April 22,2024

Psoriasis patients can get clearer skin with at-home treatment instead of at doctors' offices, study suggests

by Alex Gardner,Perelman School of Medicine at the University of PennsylvaniaCredit: Estzer Miller on PixabayFor decades, people with psoriasis have been treated in clinics with narrowband ultra

Updated on: October 28,2024

Psoriasis patients can get clearer skin with at-home treatment instead of at doctors' offices, study suggests

by Alex Gardner,Perelman School of Medicine at the University of PennsylvaniaCredit: Estzer Miller on PixabayFor decades, people with psoriasis have been treated in clinics with narrowband ultra

Updated on:October 28,2024

An extra X chromosome-linked gene may explain decreased viral infection severity in females

by University of California, Los AngelesCredit: CC0 Public DomainIt has long been known that viral infections can be more severe in males than females, but the question as to why has remained a m

Updated on: April 24,2024

An extra X chromosome-linked gene may explain decreased viral infection severity in females

by University of California, Los AngelesCredit: CC0 Public DomainIt has long been known that viral infections can be more severe in males than females, but the question as to why has remained a m

Updated on:April 24,2024

Genetics can explain why infections trigger onset of different types of rheumatoid arthritis

by Jane Tadman, Arthritis Research UKA hand affected by rheumatoid arthritis. Credit: James Heilman, MD/Wikipedia(Medical Xpress)—A new international study has revealed how genetics could explain why

Updated on: May 13,2024

Genetics can explain why infections trigger onset of different types of rheumatoid arthritis

by Jane Tadman, Arthritis Research UKA hand affected by rheumatoid arthritis. Credit: James Heilman, MD/Wikipedia(Medical Xpress)—A new international study has revealed how genetics could explain why

Updated on:May 13,2024