STIM-mediated calcium influx regulates maintenance and selection of germinal center B cells: Study

by Osaka UniversityCredit:Journal of Experimental Medicine(2023). DOI: 10.1084/jem.20222178Germinal centers (GCs) are specialized microenvironments where antigen (Ag)-specific B cells

Updated on: April 22,2024 13

STIM-mediated calcium influx regulates maintenance and selection of germinal center B cells: Study

by Osaka UniversityCredit:Journal of Experimental Medicine(2023). DOI: 10.1084/jem.20222178Germinal centers (GCs) are specialized microenvironments where antigen (Ag)-specific B cells

Updated on:April 22,2024 13

Combined inhibition of TNF-alpha, IL-17 effective in RA model

(HealthDay)—Combined inhibition of tumor necrosis factor (TNF) α and interleukin (IL)-17 is more effective than single blockade in cultures of human fibroblast-like synoviocytes (FLS), according to an

Updated on: April 08,2024 11

Combined inhibition of TNF-alpha, IL-17 effective in RA model

(HealthDay)—Combined inhibition of tumor necrosis factor (TNF) α and interleukin (IL)-17 is more effective than single blockade in cultures of human fibroblast-like synoviocytes (FLS), according to an

Updated on:April 08,2024 11

CARv3-TEAM-E T-cell treatment beneficial for recurrent glioblastoma

by Elana GotkineFor patients with recurrent glioblastoma, treatment with chimeric antigen receptor (CAR) T-cells engineered to target the epidermal growth factor receptor (EGFR) variant III tumor-spec

Updated on: March 27,2024 0

CARv3-TEAM-E T-cell treatment beneficial for recurrent glioblastoma

by Elana GotkineFor patients with recurrent glioblastoma, treatment with chimeric antigen receptor (CAR) T-cells engineered to target the epidermal growth factor receptor (EGFR) variant III tumor-spec

Updated on:March 27,2024 0

Developing new classification criteria for improving antiphospholipid syndrome research

by Hospital for Special SurgeryCredit: CC0 Public DomainAn international team of more than 80 collaborators led by Hospital for Special Surgery (HSS) investigators is developing new classificatio

Updated on: March 26,2024 13

Developing new classification criteria for improving antiphospholipid syndrome research

by Hospital for Special SurgeryCredit: CC0 Public DomainAn international team of more than 80 collaborators led by Hospital for Special Surgery (HSS) investigators is developing new classificatio

Updated on:March 26,2024 13

A mathematical model that predicts how severe hay fever season will be

by Bob Yirka , Medical XpressCredit: Pixabay/CC0 Public DomainAn international team of researchers has developed a mathematical model for predicting how bad an upcoming hay fever season will be. In th

Updated on: May 07,2024 10

A mathematical model that predicts how severe hay fever season will be

by Bob Yirka , Medical XpressCredit: Pixabay/CC0 Public DomainAn international team of researchers has developed a mathematical model for predicting how bad an upcoming hay fever season will be. In th

Updated on:May 07,2024 10

TET proteins regulate factors essential for normal antibody production

by La Jolla Institute for ImmunologyMutant B cells lacking TET2 and TET3 produce an overabundance of a class of antibody called IgM, whereas normal control B cells churned out more effective antibodie

Updated on: April 24,2024 20

TET proteins regulate factors essential for normal antibody production

by La Jolla Institute for ImmunologyMutant B cells lacking TET2 and TET3 produce an overabundance of a class of antibody called IgM, whereas normal control B cells churned out more effective antibodie

Updated on:April 24,2024 20

An infamous 'inflammasome'—a rogue protein complex—appears to underlie a rare and disabling autoimmune disorder

by Delthia Ricks , Medical XpressCa2+ influx is required for PIEZO-dependent NLRP3 inflammasome activation. Credit:Science Immunology(2023). DOI: 10.1126/sciimmunol.adf4699Autoimmune disea

Updated on: March 30,2024 8

An infamous 'inflammasome'—a rogue protein complex—appears to underlie a rare and disabling autoimmune disorder

by Delthia Ricks , Medical XpressCa2+ influx is required for PIEZO-dependent NLRP3 inflammasome activation. Credit:Science Immunology(2023). DOI: 10.1126/sciimmunol.adf4699Autoimmune disea

Updated on:March 30,2024 8

Moms with lupus more likely to have children with autism, study suggests

by Serena Gordon, Healthday ReporterBut overall risk is low, shouldn't influence parenting decisions, expert says.(HealthDay)—Women with lupus are twice as likely to have a child with autism compa

Updated on: March 24,2024 13

Moms with lupus more likely to have children with autism, study suggests

by Serena Gordon, Healthday ReporterBut overall risk is low, shouldn't influence parenting decisions, expert says.(HealthDay)—Women with lupus are twice as likely to have a child with autism compa

Updated on:March 24,2024 13

A turncoat protein allows viruses to ride roughshod in the liver, paving the way to cancer

by Delthia Ricks , Medical XpressImages showing the distribution of tagged STING and HA-HPN proteins in liver cells. Credit: F. Hsin et al.,Science Signaling(2021)Chronic viral infections

Updated on: April 24,2024 19

A turncoat protein allows viruses to ride roughshod in the liver, paving the way to cancer

by Delthia Ricks , Medical XpressImages showing the distribution of tagged STING and HA-HPN proteins in liver cells. Credit: F. Hsin et al.,Science Signaling(2021)Chronic viral infections

Updated on:April 24,2024 19

Certain criteria may be better than others in RA assessment

(HealthDay)—For patients with rheumatoid arthritis (RA), the performances of the Clinical Disease Activity Index (CDAI) and Simplified Disease Activity Index (SDAI) appear to be better than that of th

Updated on: March 30,2024 13

Certain criteria may be better than others in RA assessment

(HealthDay)—For patients with rheumatoid arthritis (RA), the performances of the Clinical Disease Activity Index (CDAI) and Simplified Disease Activity Index (SDAI) appear to be better than that of th

Updated on:March 30,2024 13

Targeting ion channels to manage osteoarthritis pain

by Melissa Rohman,Northwestern UniversityThe image depicts two drug receptor sites with the molecular structure of the Nav1.7 channel, and tamoxifen’s attenuation of nociceptor action potentials

Updated on: May 14,2024 3

Targeting ion channels to manage osteoarthritis pain

by Melissa Rohman,Northwestern UniversityThe image depicts two drug receptor sites with the molecular structure of the Nav1.7 channel, and tamoxifen’s attenuation of nociceptor action potentials

Updated on:May 14,2024 3

Allergy diary' phone app classifies phenotypes in rhinitis

(HealthDay)—TheAllergy Diaryphone app can identify phenotypic differences between rhinitis groups, according to a study published online Jan. 10 inAllergy.Jean Bousquet, M.D., from t

Updated on: March 13,2024 12

Allergy diary' phone app classifies phenotypes in rhinitis

(HealthDay)—TheAllergy Diaryphone app can identify phenotypic differences between rhinitis groups, according to a study published online Jan. 10 inAllergy.Jean Bousquet, M.D., from t

Updated on:March 13,2024 12